Author, as appears in the article.: Magre M, Pàmies O, Diéguez M
Department: Química Física i Inorgànica
URV's Author/s: Diéguez Fernández, Montserrat / Pamies Ollé, Oscar
Keywords: Phosphite-oxazoline ligands Iridium Hydrogenation Asymmetric catalysis ?-enamides
Abstract: Simple Ir-PHOX-based phosphite-oxazoline catalysts have been successfully applied in the asymmetric hydrogenation of cyclic ¿-enamides providing better enantioselectivities than previous effective Ru and Rh catalysts. This protocol allows the synthesis of 2-aminotetralines and 3-aminochromanes, key structural units found in many therapeutic agents and biologically active natural products, in high chemical yields and enantioselectivities (ee's up to 99%). High enantioselectivities have also been achieved in the hydrogenation of cyclic β-enamides.
Thematic Areas: Química Materiais Interdisciplinar General chemistry Engenharias ii Ciências agrárias i Chemistry, physical Chemistry (miscellaneous) Chemistry (all) Catalysis Astronomia / física
ISSN: 21555435
Author's mail: oscar.pamies@urv.cat montserrat.dieguez@urv.cat
Author identifier: 0000-0002-2352-8508 0000-0002-8450-0656
Record's date: 2024-09-07
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Acs Catalysis. 6 (8): 5186-5190
APA: Magre M, Pàmies O, Diéguez M (2016). PHOX-Based Phosphite-Oxazoline Ligands for the Enantioselective Ir-Catalyzed Hydrogenation of Cyclic b-Enamides. Acs Catalysis, 6(8), 5186-5190. DOI: 10.1021/acscatal.6b01314
Article's DOI: 10.1021/acscatal.6b01314
Entity: Universitat Rovira i Virgili
Journal publication year: 2016
Publication Type: Journal Publications
Repositori URV