Autor segons l'article: Vincent, Antony T; Fernandez-Bravo, Ana; Sanchis, Marta; Mayayo, Emilio; Jose Figueras, Maria; Charette, Steve J
Departament: Ciències Mèdiques Bàsiques
Autor/s de la URV: Fernández Bravo, Ana / Figueras Salvat, María Josefa / Mayayo Artal, Emilio Manuel / Sanchis Talón, Marta
Paraules clau: Whole genome sequencing; Virulence; Type iii secretion systems; Temperature; Spain; Resistance; Phylogeny; Pathogenicity; Necrotizing fasciitis; Middle aged; Mice; Male; Infection; Iii secretion system; Identification; Humans; Gram-negative bacterial infections; Genomics; Genome, bacterial; Genes; Female; Child; Biopsy; Bacterial load; Animals; Aeromonas salmonicida; type iii secretion systems; pathogenicity; necrotizing fasciitis; infection; aeromonas salmonicida
Resum: © 2018 Elsevier B.V. The bacterium Aeromonas salmonicida is known since long time as a major fish pathogen unable to grow at 37 °C. However, some cases of human infection by putative mesophilic A. salmonicida have been reported. The goal of the present study is to examine two clinical cases of human infection by A. salmonicida in Spain and to investigate the pathogenicity in mammals of selected mesophilic A. salmonicida strains. An evaluation of the pathogenicity in a mouse model of clinical and environmental A. salmonicida strains was performed. The genomes of the strains were sequenced and analyzed in order to find the virulence determinants of these strains. The experimental infection in mice showed a gradient in the virulence of these strains and that some of them can cause necrotizing fasciitis and tissue damage in the liver. In addition to demonstrating significant genomic diversity among the strains studied, bioinformatics analyses permitted also to shed light on crucial elements for the virulence of the strains, like the presence of a type III secretion system in the one that caused the highest mortality in the experimental infection. Clinicians and microbiologists should consider these results for the inclusion of A. salmonicida in diagnosis tests since it is now clear that some mesophilic strains are also pathogens for humans.
Àrees temàtiques: Zootecnia / recursos pesqueiros; Saúde coletiva; Planejamento urbano e regional / demografia; Molecular biology; Microbiology (medical); Microbiology; Medicina veterinaria; Medicina iii; Medicina ii; Medicina i; Interdisciplinar; Infectious diseases; Genetics; General medicine; Farmacia; Ensino; Enfermagem; Ecology, evolution, behavior and systematics; Ciências biológicas iii; Ciências biológicas ii; Ciências biológicas i; Ciências ambientais; Ciências agrárias i; Ciência da computação; Biotecnología; Biodiversidade
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 15671348
Adreça de correu electrònic de l'autor: marta.sanchis@urv.cat; ana.fernandez@urv.cat; mariajose.figueras@urv.cat
Data d'alta del registre: 2025-01-08
Versió de l'article dipositat: info:eu-repo/semantics/acceptedVersion
Enllaç font original: https://www.sciencedirect.com/science/article/abs/pii/S1567134818304775?via%3Dihub
URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
Referència a l'article segons font original: Infection Genetics And Evolution. 68 1-9
Referència de l'ítem segons les normes APA: Vincent, Antony T; Fernandez-Bravo, Ana; Sanchis, Marta; Mayayo, Emilio; Jose Figueras, Maria; Charette, Steve J (2019). Investigation of the virulence and genomics of Aeromonas salmonicida strains isolated from human patients. Infection Genetics And Evolution, 68(), 1-9. DOI: 10.1016/j.meegid.2018.11.019
DOI de l'article: 10.1016/j.meegid.2018.11.019
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2019
Tipus de publicació: Journal Publications
Repositori URV