Articles producció científicaCiències Mèdiques Bàsiques

Axonal competition and synapse elimination during neuromuscular junction development

  • Dades identificatives

    Identificador:  imarina:4123848
    Handle: https://hdl.handle.net/20.500.11797/imarina4123848
    Autors:  Lanuza M; Tomàs J; Garcia N; Cilleros-Mañé V; Just-Borràs L; Tomás M
    Resum:
    © 2018 Elsevier Ltd Early in development, each muscle fiber is innervated by multiple neurons. Different activities between nerve terminals on the same junction cause the elimination of all but one of them through Hebbian competition. The molecular basis of this developmental synapse modulation is still being investigated because it is a model for how the nervous system achieves the proper synaptic connectivity and function. The study of the vertebrate neuromuscular junction has proven useful to understand the carefully regulated process of axon withdrawal, locally regulated in the synaptic site by the nerve terminals themselves, the postsynaptic muscle cell and the Schwann cells. In this review, we summarize the multiple factors that have been implicated in axonal competition and synapse elimination.

  • Altres:

    Autor segons l'article: Lanuza M; Tomàs J; Garcia N; Cilleros-Mañé V; Just-Borràs L; Tomás M
    Departament: Ciències Mèdiques Bàsiques
    Autor/s de la URV: Cilleros Mañé, Víctor / Garcia Sancho, Maria de les Neus / Just Borràs, Laia / Lanuza Escolano, María Angel / Tomás Ferré, José Maria / Tomas Marginet, Marta
    Paraules clau: Hashtag; Etiqueta «#»; @uroweb; @residentesaeu; @infoAeu
    Resum: © 2018 Elsevier Ltd Early in development, each muscle fiber is innervated by multiple neurons. Different activities between nerve terminals on the same junction cause the elimination of all but one of them through Hebbian competition. The molecular basis of this developmental synapse modulation is still being investigated because it is a model for how the nervous system achieves the proper synaptic connectivity and function. The study of the vertebrate neuromuscular junction has proven useful to understand the carefully regulated process of axon withdrawal, locally regulated in the synaptic site by the nerve terminals themselves, the postsynaptic muscle cell and the Schwann cells. In this review, we summarize the multiple factors that have been implicated in axonal competition and synapse elimination.
    Àrees temàtiques: Physiology (medical); Physiology
    Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 24688673
    Adreça de correu electrònic de l'autor: laia.just@urv.cat; marta.tomas@urv.cat; victor.cilleros@alumni.urv.cat; josepmaria.tomas@urv.cat; laia.just@urv.cat; mariaangel.lanuza@urv.cat
    Data d'alta del registre: 2024-10-12
    Versió de l'article dipositat: info:eu-repo/semantics/acceptedVersion
    Enllaç font original: https://www.sciencedirect.com/science/article/pii/S2468867318300543?via%3Dihub
    URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referència a l'article segons font original: Curr Opin Physiol. 4 25-31
    Referència de l'ítem segons les normes APA: Lanuza M; Tomàs J; Garcia N; Cilleros-Mañé V; Just-Borràs L; Tomás M (2018). Axonal competition and synapse elimination during neuromuscular junction development. Curr Opin Physiol, 4(), 25-31. DOI: 10.1016/j.cophys.2018.04.001
    DOI de l'article: 10.1016/j.cophys.2018.04.001
    Entitat: Universitat Rovira i Virgili
    Any de publicació de la revista: 2018
    Tipus de publicació: Journal Publications

  • Paraules clau:

    Physiology,Physiology (Medical)
    Physiology (medical)
    Physiology

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