Donor Rhodium Carbenes by Retro-Buchner Reaction

Identificador:  imarina:4220472

Handle: https://hdl.handle.net/20.500.11797/imarina4220472

Autors:  Mato, Mauro; Echavarren, Antonio M

Resum:
Rhodium carbenes are key intermediates in a range of cycloadditions and insertion reactions. Herein, we report the first generation of donor Rh-II carbenes by decarbenation of 7-substituted 1,3,5-cycloheptatrienes. This discovery unlocks an improved retro-Buchner-cyclopropanation sequence, a Si-H insertion reaction for a broad-scope synthesis of allylsilanes, and a new method for the vinylogation of aldehydes. The last strategy led to the development of an iterative synthesis of E-polyenes, and to the total synthesis of navenonesB and C.