Autor segons l'article: Izaguirre, M.F.; Garcia, N.; Miranda, L.A.; Tomàs, J.; Casco, V.H.
Departament: Ciències Mèdiques Bàsiques
e-ISSN: 1678-4375
Autor/s de la URV: Tomás Ferré, José Maria
Resum: Cell adhesion molecules act as signal transducers from the extracellular environment to the cytoskeleton and the nucleus and consequently induce changes in the expression pattern of structural proteins. In this study, we showed the effect of thyroid hormone (TH) inhibition and arrest of metamorphosis on the expression of E-cadherin, β-and α-catenin in the developing kidney of Bufo arenarum. Cell adhesion molecules have selective temporal and spatial expression during development suggesting a specific role in nephrogenesis. In order to study mechanisms controlling the expression of adhesion molecules during renal development, we blocked the B. arenarum metamorphosis with a goitrogenic substance that blocks TH synthesis. E-cadherin expression in the proximal tubules is independent of thyroid control. However, the blockage of TH synthesis causes up-regulation of E-cadherin in the collecting ducts, the distal tubules and the glomeruli. The expression of β-and α-catenin in the collecting ducts, the distal tubules, the glomeruli and the mesonephric mesenchyme is independent of TH. TH blockage causes up-regulation of β-and α-catenin in the proximal tubules. In contrast to E-cadherin, the expression of the desmosomal cadherin desmoglein 1 (Dsg-1) is absent in the control of the larvae kidney during metamorphosis and is expressed in some interstitial cells in the KClO4 treated larvae. According to this work, the Dsg-1 expression is down-regulated by TH. We demonstrated that the expression of E-cadherin, Dsg-1, β-catenin and α-catenin are differentially affected by TH levels, suggesting a hormone-dependent role of these proteins in the B. arenarum renal metamorphosis.
Àrees temàtiques: Zootecnia / recursos pesqueiros Sociología Saúde coletiva Química Psicología Planejamento urbano e regional / demografia Odontología Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Matemática / probabilidade e estatística Interdisciplinar Geografía Geociências General agricultural and biological sciences Farmacia Ensino Engenharias iv Engenharias iii Engenharias ii Engenharias i Educação física Educação Economia Direito Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Biotecnología Biology Biodiversidade Astronomia / física Agricultural and biological sciences (miscellaneous) Agricultural and biological sciences (all) Administração pública e de empresas, ciências contábeis e turismo
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 1519-6984
Adreça de correu electrònic de l'autor: josepmaria.tomas@urv.cat
Identificador de l'autor: 0000-0002-0406-0006
Pàgina final: 569
Data d'alta del registre: 2023-04-15
Volum de revista: 68
Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
Enllaç font original: https://www.scielo.br/scielo.php?script=sci_arttext&pid=S1519-69842008000300014&lng=en&tlng=en
Referència a l'article segons font original: Brazilian Journal Of Biology. 68 (3): 631-637
Referència de l'ítem segons les normes APA: Izaguirre, M.F.; Garcia, N.; Miranda, L.A.; Tomàs, J.; Casco, V.H. (2008). Expression of cell adhesion molecules in the normal and T3 blocked development of the tadpole's kidney of Bufo arenarum (Amphibian, Anuran, Bufonidae). Brazilian Journal Of Biology, 68(3), 631-637. DOI: 10.1590/S1519-69842008000300014
URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
DOI de l'article: 10.1590/S1519-69842008000300014
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2008
Pàgina inicial: 561
Tipus de publicació: Journal Publications