Articles producció científica> Medicina i Cirurgia

De novo lipogenesis in adipose tissue is associated with course of morbid obesity after bariatric surgery.

  • Dades identificatives

    Identificador: imarina:5125976
  • Autors:

    Garrido-Sanchez, Lourdes
    Vendrell, Joan
    Fernandez-Garcia, Diego
    Ceperuelo-Mallafre, Victoria
    Chacon, Matilde R.
    Ocana-Wilhelmi, Luis
    Alcaide, Juan
    Tinahones, Francisco J.
    Garcia-Fuentes, Eduardo
  • Altres:

    Autor segons l'article: Garrido-Sanchez, Lourdes; Vendrell, Joan; Fernandez-Garcia, Diego; Ceperuelo-Mallafre, Victoria; Chacon, Matilde R.; Ocana-Wilhelmi, Luis; Alcaide, Juan; Tinahones, Francisco J.; Garcia-Fuentes, Eduardo;
    Departament: Medicina i Cirurgia
    Autor/s de la URV: Ceperuelo Mallafré, Maria Victoria / Rodríguez Chacón, Matilde / Vendrell Ortega, Juan José
    Paraules clau: Weight-loss Protects Phosphoenolpyruvate carboxykinase Overexpression Insulin-resistance Glyceroneogenesis Fatty-acid synthesis Enzyme Coenzyme-a synthetase Acetate
    Resum: De novo lipogenesis is involved in fatty acid biosynthesis and could be involved in the regulation of the triglyceride storage capacity of adipose tissue. However, the association between lipogenic and lipolytic genes and the evolution of morbidly obese subjects after bariatric surgery remains unknown. In this prospective study we analyze the association between the improvement in the morbidly obese patients as a result of bariatric surgery and the basal expression of lipogenic and lipolytic genes.We study 23 non diabetic morbidly obese patients who were studied before and 7 months after bariatric surgery. Also, we analyze the relative basal mRNA expression levels of lipogenic and lipolytic genes in epiploic visceral adipose tissue (VAT) and abdominal subcutaneous adipose tissue (SAT).When the basal acetyl-CoA carboxylase 1 (ACC1), acetyl-CoA synthetase 2 (ACSS2) and ATP citrate lyase (ACL) expression in SAT was below percentile-50, there was a greater decrease in weight (P = 0.006, P = 0.034, P = 0.026), body mass index (P = 0.008, P = 0.033, P = 0.034) and hip circumference (P = 0.033, P = 0.021, P = 0.083) after bariatric surgery. In VAT, when the basal ACSS2 expression was below percentile-50, there was a greater decrease in hip circumference (P = 0.006). After adjusting for confounding variables in logistic regression models, only the morbidly obese patients with SAT or VAT ACSS2 expression ? P50 before bariatric surgery had a lower percentage hip circumference loss (<P50) after bariatric surgery (SAT: P = 0.039; VAT: P = 0.033).A lower basal ACSS2, ACC1 and ACL expression, genes involved in de novo lipogenesis, is associated with a better evolution of anthropometric variables after bariatric surgery. Thus, the previous state of the pathways involved in fatty acid metabolism may have repercussions on the improvement of these patients.
    Àrees temàtiques: Zootecnia / recursos pesqueiros Sociology Sociología Serviço social Saúde coletiva Química Psychology Psicología Planejamento urbano e regional / demografia Odontología Nutrição Multidisciplinary sciences Multidisciplinary Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Matemática / probabilidade e estatística Linguística e literatura Letras / linguística Interdisciplinary research in the social sciences Interdisciplinar Human geography and urban studies History & philosophy of science Historia Geografía Geociências General medicine General biochemistry,genetics and molecular biology General agricultural and biological sciences Farmacia Environmental studies Ensino Engenharias iv Engenharias iii Engenharias ii Engenharias i Enfermagem Educação física Educação Economia Direito Demography Comunicação e informação Ciências sociais aplicadas i Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência política e relações internacionais Ciência de alimentos Ciência da computação Biotecnología Biology Biodiversidade Biochemistry, genetics and molecular biology (miscellaneous) Astronomia / física Arquitetura, urbanismo e design Archaeology Antropologia / arqueologia Anthropology Agricultural and biological sciences (miscellaneous) Administração, ciências contábeis e turismo Administração pública e de empresas, ciências contábeis e turismo
    Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
    Adreça de correu electrònic de l'autor: matilde.rodriguez@urv.cat victoria.ceperuelo@urv.cat juanjose.vendrell@urv.cat
    Identificador de l'autor: 0000-0002-4460-9761 0000-0002-6994-6115
    Data d'alta del registre: 2023-10-07
    Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
    Enllaç font original: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0031280
    Referència a l'article segons font original: Plos One. 7 (2): e31280-
    Referència de l'ítem segons les normes APA: Garrido-Sanchez, Lourdes; Vendrell, Joan; Fernandez-Garcia, Diego; Ceperuelo-Mallafre, Victoria; Chacon, Matilde R.; Ocana-Wilhelmi, Luis; Alcaide, Ju (2012). De novo lipogenesis in adipose tissue is associated with course of morbid obesity after bariatric surgery.. Plos One, 7(2), e31280-. DOI: 10.1371/journal.pone.0031280
    URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
    DOI de l'article: 10.1371/journal.pone.0031280
    Entitat: Universitat Rovira i Virgili
    Any de publicació de la revista: 2012
    Tipus de publicació: Journal Publications
  • Paraules clau:

    Agricultural and Biological Sciences (Miscellaneous),Biochemistry, Genetics and Molecular Biology (Miscellaneous),Biology,Medicine (Miscellaneous),Multidisciplinary,Multidisciplinary Sciences
    Weight-loss
    Protects
    Phosphoenolpyruvate carboxykinase
    Overexpression
    Insulin-resistance
    Glyceroneogenesis
    Fatty-acid synthesis
    Enzyme
    Coenzyme-a synthetase
    Acetate
    Zootecnia / recursos pesqueiros
    Sociology
    Sociología
    Serviço social
    Saúde coletiva
    Química
    Psychology
    Psicología
    Planejamento urbano e regional / demografia
    Odontología
    Nutrição
    Multidisciplinary sciences
    Multidisciplinary
    Medicine (miscellaneous)
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Materiais
    Matemática / probabilidade e estatística
    Linguística e literatura
    Letras / linguística
    Interdisciplinary research in the social sciences
    Interdisciplinar
    Human geography and urban studies
    History & philosophy of science
    Historia
    Geografía
    Geociências
    General medicine
    General biochemistry,genetics and molecular biology
    General agricultural and biological sciences
    Farmacia
    Environmental studies
    Ensino
    Engenharias iv
    Engenharias iii
    Engenharias ii
    Engenharias i
    Enfermagem
    Educação física
    Educação
    Economia
    Direito
    Demography
    Comunicação e informação
    Ciências sociais aplicadas i
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Ciências agrárias i
    Ciência política e relações internacionais
    Ciência de alimentos
    Ciência da computação
    Biotecnología
    Biology
    Biodiversidade
    Biochemistry, genetics and molecular biology (miscellaneous)
    Astronomia / física
    Arquitetura, urbanismo e design
    Archaeology
    Antropologia / arqueologia
    Anthropology
    Agricultural and biological sciences (miscellaneous)
    Administração, ciências contábeis e turismo
    Administração pública e de empresas, ciências contábeis
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