Repositori URV

Autor segons l'article: Garrido-Sanchez, Lourdes; Vendrell, Joan; Fernandez-Garcia, Diego; Ceperuelo-Mallafre, Victoria; Chacon, Matilde R.; Ocana-Wilhelmi, Luis; Alcaide, Juan; Tinahones, Francisco J.; Garcia-Fuentes, Eduardo;

Departament: Medicina i Cirurgia

Autor/s de la URV: Ceperuelo Mallafré, Maria Victoria / Rodríguez Chacón, Matilde / Vendrell Ortega, Juan José

Paraules clau: Weight-loss Protects Phosphoenolpyruvate carboxykinase Overexpression Insulin-resistance Glyceroneogenesis Fatty-acid synthesis Enzyme Coenzyme-a synthetase Acetate

Resum: De novo lipogenesis is involved in fatty acid biosynthesis and could be involved in the regulation of the triglyceride storage capacity of adipose tissue. However, the association between lipogenic and lipolytic genes and the evolution of morbidly obese subjects after bariatric surgery remains unknown. In this prospective study we analyze the association between the improvement in the morbidly obese patients as a result of bariatric surgery and the basal expression of lipogenic and lipolytic genes.We study 23 non diabetic morbidly obese patients who were studied before and 7 months after bariatric surgery. Also, we analyze the relative basal mRNA expression levels of lipogenic and lipolytic genes in epiploic visceral adipose tissue (VAT) and abdominal subcutaneous adipose tissue (SAT).When the basal acetyl-CoA carboxylase 1 (ACC1), acetyl-CoA synthetase 2 (ACSS2) and ATP citrate lyase (ACL) expression in SAT was below percentile-50, there was a greater decrease in weight (P = 0.006, P = 0.034, P = 0.026), body mass index (P = 0.008, P = 0.033, P = 0.034) and hip circumference (P = 0.033, P = 0.021, P = 0.083) after bariatric surgery. In VAT, when the basal ACSS2 expression was below percentile-50, there was a greater decrease in hip circumference (P = 0.006). After adjusting for confounding variables in logistic regression models, only the morbidly obese patients with SAT or VAT ACSS2 expression ? P50 before bariatric surgery had a lower percentage hip circumference loss (<P50) after bariatric surgery (SAT: P = 0.039; VAT: P = 0.033).A lower basal ACSS2, ACC1 and ACL expression, genes involved in de novo lipogenesis, is associated with a better evolution of anthropometric variables after bariatric surgery. Thus, the previous state of the pathways involved in fatty acid metabolism may have repercussions on the improvement of these patients.

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Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/

Adreça de correu electrònic de l'autor: matilde.rodriguez@urv.cat victoria.ceperuelo@urv.cat juanjose.vendrell@urv.cat

Identificador de l'autor: 0000-0002-4460-9761 0000-0002-6994-6115

Data d'alta del registre: 2023-10-07

Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion

Referència a l'article segons font original: Plos One. 7 (2): e31280-

Referència de l'ítem segons les normes APA: Garrido-Sanchez, Lourdes; Vendrell, Joan; Fernandez-Garcia, Diego; Ceperuelo-Mallafre, Victoria; Chacon, Matilde R.; Ocana-Wilhelmi, Luis; Alcaide, Ju (2012). De novo lipogenesis in adipose tissue is associated with course of morbid obesity after bariatric surgery.. Plos One, 7(2), e31280-. DOI: 10.1371/journal.pone.0031280

URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/

Entitat: Universitat Rovira i Virgili

Any de publicació de la revista: 2012

Tipus de publicació: Journal Publications