Repositori URV

Autor según el artículo: Garrido-Sanchez, Lourdes; Vendrell, Joan; Fernandez-Garcia, Diego; Ceperuelo-Mallafre, Victoria; Chacon, Matilde R.; Ocana-Wilhelmi, Luis; Alcaide, Juan; Tinahones, Francisco J.; Garcia-Fuentes, Eduardo;

Departamento: Medicina i Cirurgia

Autor/es de la URV: Ceperuelo Mallafré, Maria Victoria / Rodríguez Chacón, Matilde / Vendrell Ortega, Juan José

Palabras clave: Weight-loss Protects Phosphoenolpyruvate carboxykinase Overexpression Insulin-resistance Glyceroneogenesis Fatty-acid synthesis Enzyme Coenzyme-a synthetase Acetate

Resumen: De novo lipogenesis is involved in fatty acid biosynthesis and could be involved in the regulation of the triglyceride storage capacity of adipose tissue. However, the association between lipogenic and lipolytic genes and the evolution of morbidly obese subjects after bariatric surgery remains unknown. In this prospective study we analyze the association between the improvement in the morbidly obese patients as a result of bariatric surgery and the basal expression of lipogenic and lipolytic genes.We study 23 non diabetic morbidly obese patients who were studied before and 7 months after bariatric surgery. Also, we analyze the relative basal mRNA expression levels of lipogenic and lipolytic genes in epiploic visceral adipose tissue (VAT) and abdominal subcutaneous adipose tissue (SAT).When the basal acetyl-CoA carboxylase 1 (ACC1), acetyl-CoA synthetase 2 (ACSS2) and ATP citrate lyase (ACL) expression in SAT was below percentile-50, there was a greater decrease in weight (P = 0.006, P = 0.034, P = 0.026), body mass index (P = 0.008, P = 0.033, P = 0.034) and hip circumference (P = 0.033, P = 0.021, P = 0.083) after bariatric surgery. In VAT, when the basal ACSS2 expression was below percentile-50, there was a greater decrease in hip circumference (P = 0.006). After adjusting for confounding variables in logistic regression models, only the morbidly obese patients with SAT or VAT ACSS2 expression ? P50 before bariatric surgery had a lower percentage hip circumference loss (<P50) after bariatric surgery (SAT: P = 0.039; VAT: P = 0.033).A lower basal ACSS2, ACC1 and ACL expression, genes involved in de novo lipogenesis, is associated with a better evolution of anthropometric variables after bariatric surgery. Thus, the previous state of the pathways involved in fatty acid metabolism may have repercussions on the improvement of these patients.

Áreas temáticas: Zootecnia / recursos pesqueiros Sociology Sociología Serviço social Saúde coletiva Química Psychology Psicología Planejamento urbano e regional / demografia Odontología Nutrição Multidisciplinary sciences Multidisciplinary Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Matemática / probabilidade e estatística Linguística e literatura Letras / linguística Interdisciplinary research in the social sciences Interdisciplinar Human geography and urban studies History & philosophy of science Historia Geografía Geociências General medicine General biochemistry,genetics and molecular biology General agricultural and biological sciences Farmacia Environmental studies Ensino Engenharias iv Engenharias iii Engenharias ii Engenharias i Enfermagem Educação física Educação Economia Direito Demography Comunicação e informação Ciências sociais aplicadas i Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência política e relações internacionais Ciência de alimentos Ciência da computação Biotecnología Biology Biodiversidade Biochemistry, genetics and molecular biology (miscellaneous) Astronomia / física Arquitetura, urbanismo e design Archaeology Antropologia / arqueologia Anthropology Agricultural and biological sciences (miscellaneous) Administração, ciências contábeis e turismo Administração pública e de empresas, ciências contábeis e turismo

Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/

Direcció de correo del autor: matilde.rodriguez@urv.cat victoria.ceperuelo@urv.cat juanjose.vendrell@urv.cat

Identificador del autor: 0000-0002-4460-9761 0000-0002-6994-6115

Fecha de alta del registro: 2023-10-07

Versión del articulo depositado: info:eu-repo/semantics/publishedVersion

Enlace a la fuente original: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0031280

Referencia al articulo segun fuente origial: Plos One. 7 (2): e31280-

Referencia de l'ítem segons les normes APA: Garrido-Sanchez, Lourdes; Vendrell, Joan; Fernandez-Garcia, Diego; Ceperuelo-Mallafre, Victoria; Chacon, Matilde R.; Ocana-Wilhelmi, Luis; Alcaide, Ju (2012). De novo lipogenesis in adipose tissue is associated with course of morbid obesity after bariatric surgery.. Plos One, 7(2), e31280-. DOI: 10.1371/journal.pone.0031280

URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/

DOI del artículo: 10.1371/journal.pone.0031280

Entidad: Universitat Rovira i Virgili

Año de publicación de la revista: 2012

Tipo de publicación: Journal Publications