Articles producció científica> Ciències Mèdiques Bàsiques

Multilaboratory study of epidemiological cutoff values for detection of resistance in eight Candida species to fluconazole, posaconazole, and voriconazole

  • Dades identificatives

    Identificador: imarina:5127747
  • Autors:

    Espinel-Ingroff A
    Pfaller M
    Bustamante B
    Canton E
    Fothergill A
    Fuller J
    Gonzalez G
    Lass-Flörl C
    Lockhart S
    Martin-Mazuelos E
    Meis J
    Melhem M
    Ostrosky-Zeichner L
    Pelaez T
    Szeszs M
    St-Germain G
    Bonfietti L
    Guarro J
    Turnidge J
  • Altres:

    Autor segons l'article: Espinel-Ingroff A; Pfaller M; Bustamante B; Canton E; Fothergill A; Fuller J; Gonzalez G; Lass-Flörl C; Lockhart S; Martin-Mazuelos E; Meis J; Melhem M; Ostrosky-Zeichner L; Pelaez T; Szeszs M; St-Germain G; Bonfietti L; Guarro J; Turnidge J
    Departament: Ciències Mèdiques Bàsiques
    Autor/s de la URV: Guarro Artigas, Josep
    Paraules clau: Wild-type Voriconazole Susceptibility Mic distributions Mechanisms Itraconazole In-vitro Broth microdilution method Azole resistance Antifungal agents Amphotericin-b
    Resum: Although epidemiological cutoff values (ECVs) have been established for Candida spp. and the triazoles, they are based on MIC data from a single laboratory. We have established ECVs for eight Candida species and fluconazole, posaconazole, and voriconazole based on wild-type (WT) MIC distributions for isolates of C. albicans (n = 11,241 isolates), C. glabrata (7,538), C. parapsilosis (6,023), C. tropicalis (3,748), C. krusei (1,073), C. lusitaniae (574), C. guilliermondii (373), and C. dubliniensis (162). The 24-h CLSI broth microdilution MICs were collated from multiple laboratories (in Canada, Brazil, Europe, Mexico, Peru, and the United States). The ECVs for distributions originating from ≥6 laboratories, which included ≥95% of the modeled WT population, for fluconazole, posaconazole, and voriconazole were, respectively, 0.5, 0.06 and 0.03 μg/ml for C. albicans, 0.5, 0.25, and 0.03 μg/ml for C. dubliniensis, 8, 1, and 0.25 μg/ml for C. glabrata, 8, 0.5, and 0.12 μg/ml for C. guilliermondii, 32, 0.5, and 0.25 μg/ml for C. krusei, 1, 0.06, and 0.06 μg/ml for C. lusitaniae, 1, 0.25, and 0.03 μg/ml for C. parapsilosis, and 1, 0.12, and 0.06 μg/ml for C. tropicalis. The low number of MICs (<100) for other less prevalent species (C. famata, C. kefyr, C. orthopsilosis, C. rugosa) precluded ECV definition, but their MIC distributions are documented. Evaluation of our ECVs for some species/agent combinations using published individual MICs for 136 isolates (harboring mutations in or upregulation of ERG11, MDR1, CDR1, or CDR2) and 64 WT isolates indicated that our ECVs may be useful in distinguishing WT from non-WT isolates.
    Àrees temàtiques: Saúde coletiva Química Pharmacology (medical) Pharmacology & pharmacy Pharmacology Odontología Nutrição Microbiology Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Matemática / probabilidade e estatística Interdisciplinar Infectious diseases Farmacia Ensino Engenharias iv Engenharias iii Engenharias ii Enfermagem Educação física Educação Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología Biodiversidade Astronomia / física
    Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
    Adreça de correu electrònic de l'autor: josep.guarro@urv.cat
    Identificador de l'autor: 0000-0002-7839-7568
    Data d'alta del registre: 2024-07-20
    Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
    Enllaç font original: https://journals.asm.org/doi/10.1128/aac.02615-13
    URL Document de llicència: http://repositori.urv.cat/ca/proteccio-de-dades/
    Referència a l'article segons font original: Antimicrobial Agents And Chemotherapy. 58 (4): 2006-2012
    Referència de l'ítem segons les normes APA: Espinel-Ingroff A; Pfaller M; Bustamante B; Canton E; Fothergill A; Fuller J; Gonzalez G; Lass-Flörl C; Lockhart S; Martin-Mazuelos E; Meis J; Melhem (2014). Multilaboratory study of epidemiological cutoff values for detection of resistance in eight Candida species to fluconazole, posaconazole, and voriconazole. Antimicrobial Agents And Chemotherapy, 58(4), 2006-2012. DOI: 10.1128/AAC.02615-13
    DOI de l'article: 10.1128/AAC.02615-13
    Entitat: Universitat Rovira i Virgili
    Any de publicació de la revista: 2014
    Tipus de publicació: Journal Publications
  • Paraules clau:

    Infectious Diseases,Microbiology,Pharmacology,Pharmacology & Pharmacy,Pharmacology (Medical)
    Wild-type
    Voriconazole
    Susceptibility
    Mic distributions
    Mechanisms
    Itraconazole
    In-vitro
    Broth microdilution method
    Azole resistance
    Antifungal agents
    Amphotericin-b
    Saúde coletiva
    Química
    Pharmacology (medical)
    Pharmacology & pharmacy
    Pharmacology
    Odontología
    Nutrição
    Microbiology
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Materiais
    Matemática / probabilidade e estatística
    Interdisciplinar
    Infectious diseases
    Farmacia
    Ensino
    Engenharias iv
    Engenharias iii
    Engenharias ii
    Enfermagem
    Educação física
    Educação
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências agrárias i
    Ciência de alimentos
    Biotecnología
    Biodiversidade
    Astronomia / física
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