Autor segons l'article: Nunez, Mireia; Borrull, Francesc; Fontanals, Nuria; Pocurull, Eva
Departament: Química Analítica i Química Orgànica
Autor/s de la URV: Borrull Ballarín, Francesc / Fontanals Torroja, Núria / NÚÑEZ MARCÉ, MIREIA / Pocurull Aixala, Eva
Paraules clau: Quechers Pharmaceuticals Liquid-liquid extraction Liquid chromatography-tandem mass spectrometry Liquid chromatography Chromatography Bivalves
Resum: A method for the quantitative determination of seven pharmaceuticals in bivalves was developed by QuEChERS (Quick, Easy, Cheap, Effective, Rugged and Safe) extraction, followed by liquid chromatography-tandem mass spectrometry (LC-MS/MS) with electrospray ionization. Both the European Standard Method EN 15662 and the AOAC Official Method 2007.01 for QuEChERS were tested. In addition, several clean-up strategies were evaluated in order to clean the matrix previous to the LC-MS/MS analyses. Dispersive solid-phase extraction with silica gel and modification of the chromatographic separation were the clean-up strategies that gave the best results. The optimized method was validated in mussels (Mytilus galloprovincialis) and allowed the determination of pharmaceuticals at nanograms per gram levels (dry weight (d.w.)). Limits of quantification ranged from 5 to 100 ng/g. Apparent recoveries ranged from 35 to 77%. The application of this method to bivalves revealed the presence of salicylic acid at concentrations up to 103 ng/g (d.w.).
Àrees temàtiques: Zootecnia / recursos pesqueiros Saúde coletiva Química Odontología Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Geociências General medicine Farmacia Ensino Engenharias iv Engenharias iii Engenharias ii Engenharias i Educação física Educação Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Ciência da computação Chemistry, analytical Biotecnología Biodiversidade Biochemistry Biochemical research methods Astronomia / física Analytical chemistry
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 16182642
Adreça de correu electrònic de l'autor: nuria.fontanals@urv.cat nuria.fontanals@urv.cat eva.pocurull@urv.cat francesc.borrull@urv.cat
Identificador de l'autor: 0000-0002-7534-1964 0000-0002-7534-1964 0000-0001-5123-995X 0000-0003-2718-9336
Data d'alta del registre: 2024-10-12
Volum de revista: 407
Versió de l'article dipositat: info:eu-repo/semantics/acceptedVersion
URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
Referència a l'article segons font original: Analytical And Bioanalytical Chemistry. 407 (13): 3841-3849
Referència de l'ítem segons les normes APA: Nunez, Mireia; Borrull, Francesc; Fontanals, Nuria; Pocurull, Eva (2015). Determination of pharmaceuticals in bivalves using QuEChERS extraction and liquid chromatography-tandem mass spectrometry. Analytical And Bioanalytical Chemistry, 407(13), 3841-3849. DOI: 10.1007/s00216-015-8617-2
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2015
Tipus de publicació: Journal Publications
Repositori URV