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Determination of pharmaceuticals in bivalves using QuEChERS extraction and liquid chromatography-tandem mass spectrometry

  • Dades identificatives

    Identificador: imarina:5129048
    Autors:
    Nunez, MireiaBorrull, FrancescFontanals, NuriaPocurull, Eva
    Resum:
    A method for the quantitative determination of seven pharmaceuticals in bivalves was developed by QuEChERS (Quick, Easy, Cheap, Effective, Rugged and Safe) extraction, followed by liquid chromatography-tandem mass spectrometry (LC-MS/MS) with electrospray ionization. Both the European Standard Method EN 15662 and the AOAC Official Method 2007.01 for QuEChERS were tested. In addition, several clean-up strategies were evaluated in order to clean the matrix previous to the LC-MS/MS analyses. Dispersive solid-phase extraction with silica gel and modification of the chromatographic separation were the clean-up strategies that gave the best results. The optimized method was validated in mussels (Mytilus galloprovincialis) and allowed the determination of pharmaceuticals at nanograms per gram levels (dry weight (d.w.)). Limits of quantification ranged from 5 to 100 ng/g. Apparent recoveries ranged from 35 to 77%. The application of this method to bivalves revealed the presence of salicylic acid at concentrations up to 103 ng/g (d.w.).
  • Altres:

    Autor segons l'article: Nunez, Mireia; Borrull, Francesc; Fontanals, Nuria; Pocurull, Eva
    Departament: Química Analítica i Química Orgànica
    Autor/s de la URV: Borrull Ballarín, Francesc / Fontanals Torroja, Núria / NÚÑEZ MARCÉ, MIREIA / Pocurull Aixala, Eva
    Paraules clau: Quechers Pharmaceuticals Liquid-liquid extraction Liquid chromatography-tandem mass spectrometry Liquid chromatography Chromatography Bivalves
    Resum: A method for the quantitative determination of seven pharmaceuticals in bivalves was developed by QuEChERS (Quick, Easy, Cheap, Effective, Rugged and Safe) extraction, followed by liquid chromatography-tandem mass spectrometry (LC-MS/MS) with electrospray ionization. Both the European Standard Method EN 15662 and the AOAC Official Method 2007.01 for QuEChERS were tested. In addition, several clean-up strategies were evaluated in order to clean the matrix previous to the LC-MS/MS analyses. Dispersive solid-phase extraction with silica gel and modification of the chromatographic separation were the clean-up strategies that gave the best results. The optimized method was validated in mussels (Mytilus galloprovincialis) and allowed the determination of pharmaceuticals at nanograms per gram levels (dry weight (d.w.)). Limits of quantification ranged from 5 to 100 ng/g. Apparent recoveries ranged from 35 to 77%. The application of this method to bivalves revealed the presence of salicylic acid at concentrations up to 103 ng/g (d.w.).
    Àrees temàtiques: Zootecnia / recursos pesqueiros Saúde coletiva Química Odontología Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Geociências General medicine Farmacia Ensino Engenharias iv Engenharias iii Engenharias ii Engenharias i Educação física Educação Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Ciência da computação Chemistry, analytical Biotecnología Biodiversidade Biochemistry Biochemical research methods Astronomia / física Analytical chemistry
    Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 16182642
    Adreça de correu electrònic de l'autor: nuria.fontanals@urv.cat nuria.fontanals@urv.cat eva.pocurull@urv.cat francesc.borrull@urv.cat
    Identificador de l'autor: 0000-0002-7534-1964 0000-0002-7534-1964 0000-0001-5123-995X 0000-0003-2718-9336
    Data d'alta del registre: 2024-10-12
    Volum de revista: 407
    Versió de l'article dipositat: info:eu-repo/semantics/acceptedVersion
    Enllaç font original: https://link.springer.com/article/10.1007/s00216-015-8617-2
    URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referència a l'article segons font original: Analytical And Bioanalytical Chemistry. 407 (13): 3841-3849
    Referència de l'ítem segons les normes APA: Nunez, Mireia; Borrull, Francesc; Fontanals, Nuria; Pocurull, Eva (2015). Determination of pharmaceuticals in bivalves using QuEChERS extraction and liquid chromatography-tandem mass spectrometry. Analytical And Bioanalytical Chemistry, 407(13), 3841-3849. DOI: 10.1007/s00216-015-8617-2
    DOI de l'article: 10.1007/s00216-015-8617-2
    Entitat: Universitat Rovira i Virgili
    Any de publicació de la revista: 2015
    Tipus de publicació: Journal Publications
  • Paraules clau:

    Analytical Chemistry,Biochemical Research Methods,Biochemistry,Chemistry, Analytical
    Quechers
    Pharmaceuticals
    Liquid-liquid extraction
    Liquid chromatography-tandem mass spectrometry
    Liquid chromatography
    Chromatography
    Bivalves
    Zootecnia / recursos pesqueiros
    Saúde coletiva
    Química
    Odontología
    Nutrição
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Materiais
    Interdisciplinar
    Geociências
    General medicine
    Farmacia
    Ensino
    Engenharias iv
    Engenharias iii
    Engenharias ii
    Engenharias i
    Educação física
    Educação
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Ciências agrárias i
    Ciência de alimentos
    Ciência da computação
    Chemistry, analytical
    Biotecnología
    Biodiversidade
    Biochemistry
    Biochemical research methods
    Astronomia / física
    Analytical chemistry
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