Author, as appears in the article.: Nunez, Mireia; Borrull, Francesc; Fontanals, Nuria; Pocurull, Eva
Department: Química Analítica i Química Orgànica
URV's Author/s: Borrull Ballarín, Francesc / Fontanals Torroja, Núria / NÚÑEZ MARCÉ, MIREIA / Pocurull Aixala, Eva
Keywords: Quechers Pharmaceuticals Liquid-liquid extraction Liquid chromatography-tandem mass spectrometry Liquid chromatography Chromatography Bivalves
Abstract: A method for the quantitative determination of seven pharmaceuticals in bivalves was developed by QuEChERS (Quick, Easy, Cheap, Effective, Rugged and Safe) extraction, followed by liquid chromatography-tandem mass spectrometry (LC-MS/MS) with electrospray ionization. Both the European Standard Method EN 15662 and the AOAC Official Method 2007.01 for QuEChERS were tested. In addition, several clean-up strategies were evaluated in order to clean the matrix previous to the LC-MS/MS analyses. Dispersive solid-phase extraction with silica gel and modification of the chromatographic separation were the clean-up strategies that gave the best results. The optimized method was validated in mussels (Mytilus galloprovincialis) and allowed the determination of pharmaceuticals at nanograms per gram levels (dry weight (d.w.)). Limits of quantification ranged from 5 to 100 ng/g. Apparent recoveries ranged from 35 to 77%. The application of this method to bivalves revealed the presence of salicylic acid at concentrations up to 103 ng/g (d.w.).
Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Química Odontología Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Geociências General medicine Farmacia Ensino Engenharias iv Engenharias iii Engenharias ii Engenharias i Educação física Educação Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Ciência da computação Chemistry, analytical Biotecnología Biodiversidade Biochemistry Biochemical research methods Astronomia / física Analytical chemistry
licence for use: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 16182642
Author's mail: nuria.fontanals@urv.cat nuria.fontanals@urv.cat eva.pocurull@urv.cat francesc.borrull@urv.cat
Author identifier: 0000-0002-7534-1964 0000-0002-7534-1964 0000-0001-5123-995X 0000-0003-2718-9336
Record's date: 2024-10-12
Journal volume: 407
Papper version: info:eu-repo/semantics/acceptedVersion
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Analytical And Bioanalytical Chemistry. 407 (13): 3841-3849
APA: Nunez, Mireia; Borrull, Francesc; Fontanals, Nuria; Pocurull, Eva (2015). Determination of pharmaceuticals in bivalves using QuEChERS extraction and liquid chromatography-tandem mass spectrometry. Analytical And Bioanalytical Chemistry, 407(13), 3841-3849. DOI: 10.1007/s00216-015-8617-2
Entity: Universitat Rovira i Virgili
Journal publication year: 2015
Publication Type: Journal Publications
Repositori URV