Autor segons l'article: Folch, J; Ettcheto, M; Petrov, D; Abad, S; Pedros, I; Marin, M; Olloquequi, J; Camins, A
Departament: Bioquímica i Biotecnologia
Autor/s de la URV: Folch Lopez, Jaume
Paraules clau: Solanezumab Humans Hipótesis amiloidea Gamma-secretase Gamma-secretasa Beta-secretase Beta-secretasa Beta-amyloid Beta-amiloide App protein, human Antibodies, monoclonal, humanized Amyloid precursor protein secretases Amyloid hypotheses Amyloid beta-protein precursor Amyloid beta-peptides Alzheimer disease Alzheimer gamma-secretase gamma-secretasa beta-secretase beta-secretasa beta-amyloid beta-amiloide amyloid hypotheses alzheimer disease alzheimer
Resum: Alzheimer disease (AD) is a major neurodegenerative disorder which eventually results in total intellectual disability. The high global prevalence and the socioeconomic burden associated with the disease pose major challenges for public health in the 21st century. In this review we focus on both existing treatments and the therapies being developed, which principally target the β-amyloid protein. DISCUSSION: The amyloidogenic hypothesis proposes that β-amyloid plays a key role in AD. Several pharmacological approaches aim to reduce the formation of β-amyloid peptides by inhibiting the β-secretase and γ-secretase enzymes. In addition, both passive and active immunotherapies have been developed for the purpose of inhibiting β-amyloid peptide aggregation. CONCLUSIONS: Progress in identifying the molecular basis of AD may provide better models for understanding the causes of this neurodegenerative disease. The lack of efficacy of solanezumab (a humanised monoclonal antibody that promotes β-amyloid clearance in the brain), demonstrated by 2 recent Phase III clinical trials in patients with mild AD, suggests that the amyloidogenic hypothesis needs to be revised.
Àrees temàtiques: Psicología Neurology (clinical) Medicine (miscellaneous) Medicina ii Medicina i General medicine Clinical neurology
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 15781968
Adreça de correu electrònic de l'autor: jaume.folch@urv.cat
Identificador de l'autor: 0000-0002-5051-8858
Data d'alta del registre: 2024-10-19
Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
Enllaç font original: https://www.sciencedirect.com/science/article/pii/S021348531500064X?via%3Dihub
URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
Referència a l'article segons font original: Neurologia. 33 (1): 47-58
Referència de l'ítem segons les normes APA: Folch, J; Ettcheto, M; Petrov, D; Abad, S; Pedros, I; Marin, M; Olloquequi, J; Camins, A (2018). Una revisión de los avances en la terapéutica de la enfermedad de Alzheimer: estrategia frente a la proteína β-amiloide. [Review of the advances in treatment for Alzheimer disease: Strategies for combating β-amyloid protein].. Neurologia, 33(1), 47-58. DOI: 10.1016/j.nrl.2015.03.012
DOI de l'article: 10.1016/j.nrl.2015.03.012
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2018
Tipus de publicació: Journal Publications