Articles producció científica> Medicina i Cirurgia

Higher protein intake increases cardiac function parameters in healthy children: metabolic programming by infant nutrition-secondary analysis from a clinical trial

  • Dades identificatives

    Identificador: imarina:5129697
    Autors:
    Collell R, Closa-Monasterolo R, Ferré N, Luque V, Koletzko B, Grote V, Janas R, Verduci E, Escribano J.
    Resum:
    Background: Protein intake may modulate cardiac structure and function in pathological conditions, but there is a lack of knowledge on potential effects in healthy infants. Methods: Secondary analysis of an ongoing randomized clinical trial comparing two groups of infants receiving a higher (HP) or lower (LP) protein content formula in the first year of life, and compared with an observational group of breastfed (BF) infants. Growth and dietary intake were assessed periodically from birth to 2 y. Insulin-like growth factor 1 (IGF-1) axis parameters were analyzed at 6 mo in a blood sample. At 2 y, cardiac mass and function were assessed by echocardiography. Results: HP infants (n = 50) showed a higher BMI z-score at 2 y compared with LP (n = 47) or BF (n = 44). Cardiac function parameters were increased in the HP group compared with the LP and were directly related to the protein intake during the first 6 mo of life. Moreover, there was an increase in free IGF-1 in the HP group at 6 mo. Conclusion: A moderate increase in protein supply during the first year of life is associated with higher cardiac function parameters at 2 y. IGF-1 axis modifications may, at least in part, underlie these effects.
  • Altres:

    Autor segons l'article: Collell R, Closa-Monasterolo R, Ferré N, Luque V, Koletzko B, Grote V, Janas R, Verduci E, Escribano J.
    Departament: Medicina i Cirurgia
    Autor/s de la URV: Closa Monasterolo, Ricardo / Collell Hernández, Rosa Maria / Escribano Subías, Joaquín / Ferre Pallas, Natalia / Luque Moreno, Verònica
    Paraules clau: Weight-gain Pressure Obesity Malnutrition Left-ventricular mass Impact Igf-i Heart-disease Growth-factor-i Childhood
    Resum: Background: Protein intake may modulate cardiac structure and function in pathological conditions, but there is a lack of knowledge on potential effects in healthy infants. Methods: Secondary analysis of an ongoing randomized clinical trial comparing two groups of infants receiving a higher (HP) or lower (LP) protein content formula in the first year of life, and compared with an observational group of breastfed (BF) infants. Growth and dietary intake were assessed periodically from birth to 2 y. Insulin-like growth factor 1 (IGF-1) axis parameters were analyzed at 6 mo in a blood sample. At 2 y, cardiac mass and function were assessed by echocardiography. Results: HP infants (n = 50) showed a higher BMI z-score at 2 y compared with LP (n = 47) or BF (n = 44). Cardiac function parameters were increased in the HP group compared with the LP and were directly related to the protein intake during the first 6 mo of life. Moreover, there was an increase in free IGF-1 in the HP group at 6 mo. Conclusion: A moderate increase in protein supply during the first year of life is associated with higher cardiac function parameters at 2 y. IGF-1 axis modifications may, at least in part, underlie these effects.
    Àrees temàtiques: Serviço social Saúde coletiva Química Pediatrics, perinatology and child health Pediatrics Medicina ii Medicina i Interdisciplinar Ensino Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Biotecnología
    Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
    Adreça de correu electrònic de l'autor: veronica.luque@urv.cat rosamaria.collell@urv.cat ricardo.closa@urv.cat natalia.ferre@urv.cat joaquin.escribano@urv.cat
    Identificador de l'autor: 0000-0003-2615-8175 0000-0002-4985-4272 0000-0002-9963-4163 0000-0002-2838-1525 0000-0002-5041-459X
    Data d'alta del registre: 2024-09-07
    Versió de l'article dipositat: info:eu-repo/semantics/acceptedVersion
    Enllaç font original: https://www.nature.com/articles/pr201630
    URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referència a l'article segons font original: Pediatric Research. 79 (6): 880-888
    Referència de l'ítem segons les normes APA: Collell R, Closa-Monasterolo R, Ferré N, Luque V, Koletzko B, Grote V, Janas R, Verduci E, Escribano J. (2016). Higher protein intake increases cardiac function parameters in healthy children: metabolic programming by infant nutrition-secondary analysis from a clinical trial. Pediatric Research, 79(6), 880-888. DOI: 10.1038/pr.2016.30
    DOI de l'article: 10.1038/pr.2016.30
    Entitat: Universitat Rovira i Virgili
    Any de publicació de la revista: 2016
    Tipus de publicació: Journal Publications
  • Paraules clau:

    Pediatrics,Pediatrics, Perinatology and Child Health
    Weight-gain
    Pressure
    Obesity
    Malnutrition
    Left-ventricular mass
    Impact
    Igf-i
    Heart-disease
    Growth-factor-i
    Childhood
    Serviço social
    Saúde coletiva
    Química
    Pediatrics, perinatology and child health
    Pediatrics
    Medicina ii
    Medicina i
    Interdisciplinar
    Ensino
    Educação física
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Biotecnología
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