Autor segons l'article: Sanchis M; Capilla J; Castanheira M; Martin-Vicente A; Sutton DA; Fothergill AW; Wiederhold NP; Guarro J
Departament: Ciències Mèdiques Bàsiques
Autor/s de la URV: Capilla Luque, Javier / Guarro Artigas, Josep / Sanchis Talón, Marta
Paraules clau: Voriconazole Resistance Model Mechanisms Management Liposomal amphotericin-b Fungal infection Fluconazole Fks mutations Epidemiological cut-off value Efficacy Combination Caspofungin Candida glabrata Antifungals Animal model fungal infection epidemiological cut-off value candida glabrata antifungals animal model
Resum: In this study, 27 clinical isolates of Candida glabrata with voriconazole (VRC) minimum inhibitory concentrations (MICs) ranging from ¿0.03 ¿g/mL to 8 ¿g/mL were tested to determine whether in vitro data are predictive of in vivo efficacy. The efficacy of VRC administered at 40 mg/kg was assayed in a neutropenic murine model of disseminated infection by C. glabrata. The reduction in fungal tissue burden in the kidneys was used as a marker of treatment efficacy. VRC reduced the fungal tissue burden in mice infected with strains that had MICs below the epidemiological cut-off value (ECV) of 0.25 ¿g/mL. Variable efficacy of VRC was obtained when the MIC equalled the ECV, and VRC was ineffective when the MIC exceeded the ECV. These results suggest that the use of in vitro data could be useful to predict the outcome for infections by this fungus.
Àrees temàtiques: Saúde coletiva Química Pharmacology (medical) Pharmacology & pharmacy Odontología Nutrição Microbiology (medical) Microbiology Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Infectious diseases General medicine Farmacia Engenharias iii Engenharias ii Enfermagem Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Biotecnología Biodiversidade
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 09248579
Adreça de correu electrònic de l'autor: marta.sanchis@urv.cat javier.capilla@urv.cat
Identificador de l'autor: 0000-0001-7251-6792 0000-0002-0765-6403
Data d'alta del registre: 2024-09-07
Versió de l'article dipositat: info:eu-repo/semantics/acceptedVersion
Enllaç font original: https://www.sciencedirect.com/science/article/abs/pii/S0924857916000431?via%3Dihub
URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
Referència a l'article segons font original: International Journal Of Antimicrobial Agents. 47 (4): 286-288
Referència de l'ítem segons les normes APA: Sanchis M; Capilla J; Castanheira M; Martin-Vicente A; Sutton DA; Fothergill AW; Wiederhold NP; Guarro J (2016). Voriconazole minimum inhibitory concentrations are predictive of treatment outcome in experimental murine infections by Candida glabrata. International Journal Of Antimicrobial Agents, 47(4), 286-288. DOI: 10.1016/j.ijantimicag.2015.12.020
DOI de l'article: 10.1016/j.ijantimicag.2015.12.020
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2016
Tipus de publicació: Journal Publications
Repositori URV