Author, as appears in the article.: Sanchis M; Capilla J; Castanheira M; Martin-Vicente A; Sutton DA; Fothergill AW; Wiederhold NP; Guarro J

Department: Ciències Mèdiques Bàsiques

URV's Author/s: Capilla Luque, Javier / Guarro Artigas, Josep / Sanchis Talón, Marta

Keywords: Voriconazole Resistance Model Mechanisms Management Liposomal amphotericin-b Fungal infection Fluconazole Fks mutations Epidemiological cut-off value Efficacy Combination Caspofungin Candida glabrata Antifungals Animal model fungal infection epidemiological cut-off value candida glabrata antifungals animal model

Abstract: In this study, 27 clinical isolates of Candida glabrata with voriconazole (VRC) minimum inhibitory concentrations (MICs) ranging from ¿0.03 ¿g/mL to 8 ¿g/mL were tested to determine whether in vitro data are predictive of in vivo efficacy. The efficacy of VRC administered at 40 mg/kg was assayed in a neutropenic murine model of disseminated infection by C. glabrata. The reduction in fungal tissue burden in the kidneys was used as a marker of treatment efficacy. VRC reduced the fungal tissue burden in mice infected with strains that had MICs below the epidemiological cut-off value (ECV) of 0.25 ¿g/mL. Variable efficacy of VRC was obtained when the MIC equalled the ECV, and VRC was ineffective when the MIC exceeded the ECV. These results suggest that the use of in vitro data could be useful to predict the outcome for infections by this fungus.

Thematic Areas: Saúde coletiva Química Pharmacology (medical) Pharmacology & pharmacy Odontología Nutrição Microbiology (medical) Microbiology Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Infectious diseases General medicine Farmacia Engenharias iii Engenharias ii Enfermagem Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Biotecnología Biodiversidade

licence for use: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 09248579

Author's mail: marta.sanchis@urv.cat josep.guarro@urv.cat javier.capilla@urv.cat

Author identifier: 0000-0001-7251-6792 0000-0002-7839-7568 0000-0002-0765-6403

Record's date: 2023-02-18

Papper version: info:eu-repo/semantics/acceptedVersion

Link to the original source: https://www.sciencedirect.com/science/article/abs/pii/S0924857916000431?via%3Dihub

Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/

Papper original source: International Journal Of Antimicrobial Agents. 47 (4): 286-288

APA: Sanchis M; Capilla J; Castanheira M; Martin-Vicente A; Sutton DA; Fothergill AW; Wiederhold NP; Guarro J (2016). Voriconazole minimum inhibitory concentrations are predictive of treatment outcome in experimental murine infections by Candida glabrata. International Journal Of Antimicrobial Agents, 47(4), 286-288. DOI: 10.1016/j.ijantimicag.2015.12.020

Article's DOI: 10.1016/j.ijantimicag.2015.12.020

Entity: Universitat Rovira i Virgili

Journal publication year: 2016

Publication Type: Journal Publications