Articles producció científica> Ciències Mèdiques Bàsiques

Voriconazole minimum inhibitory concentrations are predictive of treatment outcome in experimental murine infections by Candida glabrata

  • Identification data

    Identifier: imarina:5129738
    Authors:
    Sanchis MCapilla JCastanheira MMartin-Vicente ASutton DAFothergill AWWiederhold NPGuarro J
    Abstract:
    In this study, 27 clinical isolates of Candida glabrata with voriconazole (VRC) minimum inhibitory concentrations (MICs) ranging from ¿0.03 ¿g/mL to 8 ¿g/mL were tested to determine whether in vitro data are predictive of in vivo efficacy. The efficacy of VRC administered at 40 mg/kg was assayed in a neutropenic murine model of disseminated infection by C. glabrata. The reduction in fungal tissue burden in the kidneys was used as a marker of treatment efficacy. VRC reduced the fungal tissue burden in mice infected with strains that had MICs below the epidemiological cut-off value (ECV) of 0.25 ¿g/mL. Variable efficacy of VRC was obtained when the MIC equalled the ECV, and VRC was ineffective when the MIC exceeded the ECV. These results suggest that the use of in vitro data could be useful to predict the outcome for infections by this fungus.
  • Others:

    Author, as appears in the article.: Sanchis M; Capilla J; Castanheira M; Martin-Vicente A; Sutton DA; Fothergill AW; Wiederhold NP; Guarro J
    Department: Ciències Mèdiques Bàsiques
    URV's Author/s: Capilla Luque, Javier / Guarro Artigas, Josep / Sanchis Talón, Marta
    Keywords: Voriconazole Resistance Model Mechanisms Management Liposomal amphotericin-b Fungal infection Fluconazole Fks mutations Epidemiological cut-off value Efficacy Combination Caspofungin Candida glabrata Antifungals Animal model fungal infection epidemiological cut-off value candida glabrata antifungals animal model
    Abstract: In this study, 27 clinical isolates of Candida glabrata with voriconazole (VRC) minimum inhibitory concentrations (MICs) ranging from ¿0.03 ¿g/mL to 8 ¿g/mL were tested to determine whether in vitro data are predictive of in vivo efficacy. The efficacy of VRC administered at 40 mg/kg was assayed in a neutropenic murine model of disseminated infection by C. glabrata. The reduction in fungal tissue burden in the kidneys was used as a marker of treatment efficacy. VRC reduced the fungal tissue burden in mice infected with strains that had MICs below the epidemiological cut-off value (ECV) of 0.25 ¿g/mL. Variable efficacy of VRC was obtained when the MIC equalled the ECV, and VRC was ineffective when the MIC exceeded the ECV. These results suggest that the use of in vitro data could be useful to predict the outcome for infections by this fungus.
    Thematic Areas: Saúde coletiva Química Pharmacology (medical) Pharmacology & pharmacy Odontología Nutrição Microbiology (medical) Microbiology Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Infectious diseases General medicine Farmacia Engenharias iii Engenharias ii Enfermagem Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Biotecnología Biodiversidade
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 09248579
    Author's mail: marta.sanchis@urv.cat javier.capilla@urv.cat
    Author identifier: 0000-0001-7251-6792 0000-0002-0765-6403
    Record's date: 2024-09-07
    Papper version: info:eu-repo/semantics/acceptedVersion
    Link to the original source: https://www.sciencedirect.com/science/article/abs/pii/S0924857916000431?via%3Dihub
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: International Journal Of Antimicrobial Agents. 47 (4): 286-288
    APA: Sanchis M; Capilla J; Castanheira M; Martin-Vicente A; Sutton DA; Fothergill AW; Wiederhold NP; Guarro J (2016). Voriconazole minimum inhibitory concentrations are predictive of treatment outcome in experimental murine infections by Candida glabrata. International Journal Of Antimicrobial Agents, 47(4), 286-288. DOI: 10.1016/j.ijantimicag.2015.12.020
    Article's DOI: 10.1016/j.ijantimicag.2015.12.020
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2016
    Publication Type: Journal Publications
  • Keywords:

    Infectious Diseases,Medicine (Miscellaneous),Microbiology,Microbiology (Medical),Pharmacology & Pharmacy,Pharmacology (Medical)
    Voriconazole
    Resistance
    Model
    Mechanisms
    Management
    Liposomal amphotericin-b
    Fungal infection
    Fluconazole
    Fks mutations
    Epidemiological cut-off value
    Efficacy
    Combination
    Caspofungin
    Candida glabrata
    Antifungals
    Animal model
    fungal infection
    epidemiological cut-off value
    candida glabrata
    antifungals
    animal model
    Saúde coletiva
    Química
    Pharmacology (medical)
    Pharmacology & pharmacy
    Odontología
    Nutrição
    Microbiology (medical)
    Microbiology
    Medicine (miscellaneous)
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Materiais
    Interdisciplinar
    Infectious diseases
    General medicine
    Farmacia
    Engenharias iii
    Engenharias ii
    Enfermagem
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Ciências agrárias i
    Biotecnología
    Biodiversidade
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