Autor segons l'article: Mario, Debora Nunes; Guarro, Josep; Santurio, Janio Morais; Alves, Sydney Hartz; Capilla, Javier
Departament: Ciències Mèdiques Bàsiques
Autor/s de la URV: Capilla Luque, Javier / Guarro Artigas, Josep
Paraules clau: Triazoles; Sporotrichosis; Sporothrix; Posaconazole; Microbial sensitivity tests; Mice; Good health and well-being; Drug therapy, combination; Drug resistance, multiple, fungal; Antifungal agents; Animals; Amphotericin b
Resum: We evaluated the combination of posaconazole with amphotericin B in vitro and in a murine model of systemic infections caused by Sporothrix brasiliensis and Sporothrix schenckii sensu stricto. In vitro data demonstrated a synergistic effect, and although posaconazole alone was effective against sporotrichosis, efficacy in terms of survival and burden reduction was increased with the combination. This combination might be an option against disseminated sporotrichosis, especially when itraconazole or amphotericin B at optimal doses are contraindicated.
Àrees temàtiques: Saúde coletiva; Química; Pharmacology (medical); Pharmacology & pharmacy; Pharmacology; Odontología; Nutrição; Microbiology; Medicina veterinaria; Medicina iii; Medicina ii; Medicina i; Materiais; Matemática / probabilidade e estatística; Interdisciplinar; Infectious diseases; Farmacia; Ensino; Engenharias iv; Engenharias iii; Engenharias ii; Enfermagem; Educação física; Educação; Ciências biológicas iii; Ciências biológicas ii; Ciências biológicas i; Ciências agrárias i; Ciência de alimentos; Biotecnología; Biodiversidade; Astronomia / física
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 00664804
Adreça de correu electrònic de l'autor: javier.capilla@urv.cat
Data d'alta del registre: 2025-01-08
Versió de l'article dipositat: info:eu-repo/semantics/acceptedVersion
Enllaç font original: https://aac.asm.org/content/59/8/5018
URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
Referència a l'article segons font original: Antimicrobial Agents And Chemotherapy. 59 (8): 5018-5021
Referència de l'ítem segons les normes APA: Mario, Debora Nunes; Guarro, Josep; Santurio, Janio Morais; Alves, Sydney Hartz; Capilla, Javier (2015). In vitro and in vivo efficacy of amphotericin B combined with posaconazole against experimental disseminated sporotrichosis. Antimicrobial Agents And Chemotherapy, 59(8), 5018-5021. DOI: 10.1128/AAC.00052-15
DOI de l'article: 10.1128/AAC.00052-15
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2015
Tipus de publicació: Journal Publications
Repositori URV