Author, as appears in the article.: Mario, Debora Nunes; Guarro, Josep; Santurio, Janio Morais; Alves, Sydney Hartz; Capilla, Javier
Department: Ciències Mèdiques Bàsiques
URV's Author/s: Capilla Luque, Javier / Guarro Artigas, Josep
Keywords: Triazoles; Sporotrichosis; Sporothrix; Posaconazole; Microbial sensitivity tests; Mice; Good health and well-being; Drug therapy, combination; Drug resistance, multiple, fungal; Antifungal agents; Animals; Amphotericin b
Abstract: We evaluated the combination of posaconazole with amphotericin B in vitro and in a murine model of systemic infections caused by Sporothrix brasiliensis and Sporothrix schenckii sensu stricto. In vitro data demonstrated a synergistic effect, and although posaconazole alone was effective against sporotrichosis, efficacy in terms of survival and burden reduction was increased with the combination. This combination might be an option against disseminated sporotrichosis, especially when itraconazole or amphotericin B at optimal doses are contraindicated.
Thematic Areas: Saúde coletiva; Química; Pharmacology (medical); Pharmacology & pharmacy; Pharmacology; Odontología; Nutrição; Microbiology; Medicina veterinaria; Medicina iii; Medicina ii; Medicina i; Materiais; Matemática / probabilidade e estatística; Interdisciplinar; Infectious diseases; Farmacia; Ensino; Engenharias iv; Engenharias iii; Engenharias ii; Enfermagem; Educação física; Educação; Ciências biológicas iii; Ciências biológicas ii; Ciências biológicas i; Ciências agrárias i; Ciência de alimentos; Biotecnología; Biodiversidade; Astronomia / física
licence for use: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 00664804
Author's mail: javier.capilla@urv.cat
Record's date: 2025-01-08
Paper version: info:eu-repo/semantics/acceptedVersion
Link to the original source: https://aac.asm.org/content/59/8/5018
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Paper original source: Antimicrobial Agents And Chemotherapy. 59 (8): 5018-5021
APA: Mario, Debora Nunes; Guarro, Josep; Santurio, Janio Morais; Alves, Sydney Hartz; Capilla, Javier (2015). In vitro and in vivo efficacy of amphotericin B combined with posaconazole against experimental disseminated sporotrichosis. Antimicrobial Agents And Chemotherapy, 59(8), 5018-5021. DOI: 10.1128/AAC.00052-15
Article's DOI: 10.1128/AAC.00052-15
Entity: Universitat Rovira i Virgili
Journal publication year: 2015
Publication Type: Journal Publications
Repositori URV