Articles producció científica> Ciències Mèdiques Bàsiques

Does a triple combination have better activity than double combinations against multiresistant fungi? Experimental in vitro evaluation.

  • Dades identificatives

    Identificador: imarina:5131118
    Autors:
    Martin-Vicente A, Guarro J, Capilla J
    Resum:
    In this study, the in vitro interactions of amphotericin B (AmB), voriconazole (VRC) and anidulafungin (AFG) in double and triple combinations against four species of multiresistant fungi (Fusarium solani, Lomentospora prolificans, Scopulariopsis brevicaulis and Scopulariopsis brumptii) were evaluated. In general, AmB combined with AFG was the most synergistic, especially against F. solani (7/8; 87.5%) when low concentrations of AmB were used, i.e. 0.125-0.5 µg/mL. The least active combination was AmB + VRC, with the lowest percentage of synergy against S. brevicaulis (2/11; 18.2%) and, in general, high concentrations of both antifungals were needed to achieve synergy. The triple combination was also highly synergistic against F. solani and S. brevicaulis, especially when the lowest concentrations of AmB were used, suggesting that use of combined therapies would reduce the toxicity of therapy. The triple combination was more effective than the double combinations in some cases, but not against all strains, suggesting that administration of three drugs is not always useful in the treatment of infections due to multiresistant fungi.
  • Altres:

    Autor segons l'article: Martin-Vicente A, Guarro J, Capilla J
    Departament: Ciències Mèdiques Bàsiques
    Autor/s de la URV: Capilla Luque, Javier / Guarro Artigas, Josep
    Paraules clau: Transplant recipient Scopulariopsis brumptii Scopulariopsis brevicaulis Scopulariopsis Scedosporium-prolificans Murine model Lomentospora prolificans Invasive aspergillosis In vitro Fusarium solani Fusarium Filamentous fungi Caspofungin Antifungal drugs Antifungal combinations Amphotericin-b scopulariopsis brevicaulis lomentospora prolificans in vitro fusarium solani antifungal combinations
    Resum: In this study, the in vitro interactions of amphotericin B (AmB), voriconazole (VRC) and anidulafungin (AFG) in double and triple combinations against four species of multiresistant fungi (Fusarium solani, Lomentospora prolificans, Scopulariopsis brevicaulis and Scopulariopsis brumptii) were evaluated. In general, AmB combined with AFG was the most synergistic, especially against F. solani (7/8; 87.5%) when low concentrations of AmB were used, i.e. 0.125-0.5 µg/mL. The least active combination was AmB + VRC, with the lowest percentage of synergy against S. brevicaulis (2/11; 18.2%) and, in general, high concentrations of both antifungals were needed to achieve synergy. The triple combination was also highly synergistic against F. solani and S. brevicaulis, especially when the lowest concentrations of AmB were used, suggesting that use of combined therapies would reduce the toxicity of therapy. The triple combination was more effective than the double combinations in some cases, but not against all strains, suggesting that administration of three drugs is not always useful in the treatment of infections due to multiresistant fungi.
    Àrees temàtiques: Saúde coletiva Química Pharmacology (medical) Pharmacology & pharmacy Odontología Nutrição Microbiology (medical) Microbiology Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Infectious diseases General medicine Farmacia Engenharias iii Engenharias ii Enfermagem Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Biotecnología Biodiversidade
    Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 09248579
    Adreça de correu electrònic de l'autor: javier.capilla@urv.cat
    Identificador de l'autor: 0000-0002-0765-6403
    Data d'alta del registre: 2024-09-07
    Versió de l'article dipositat: info:eu-repo/semantics/acceptedVersion
    Enllaç font original: https://www.sciencedirect.com/science/article/abs/pii/S0924857917300614?via%3Dihub
    URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referència a l'article segons font original: International Journal Of Antimicrobial Agents. 49 (4): 422-426
    Referència de l'ítem segons les normes APA: Martin-Vicente A, Guarro J, Capilla J (2017). Does a triple combination have better activity than double combinations against multiresistant fungi? Experimental in vitro evaluation.. International Journal Of Antimicrobial Agents, 49(4), 422-426. DOI: 10.1016/j.ijantimicag.2016.12.015
    DOI de l'article: 10.1016/j.ijantimicag.2016.12.015
    Entitat: Universitat Rovira i Virgili
    Any de publicació de la revista: 2017
    Tipus de publicació: Journal Publications
  • Paraules clau:

    Infectious Diseases,Medicine (Miscellaneous),Microbiology,Microbiology (Medical),Pharmacology & Pharmacy,Pharmacology (Medical)
    Transplant recipient
    Scopulariopsis brumptii
    Scopulariopsis brevicaulis
    Scopulariopsis
    Scedosporium-prolificans
    Murine model
    Lomentospora prolificans
    Invasive aspergillosis
    In vitro
    Fusarium solani
    Fusarium
    Filamentous fungi
    Caspofungin
    Antifungal drugs
    Antifungal combinations
    Amphotericin-b
    scopulariopsis brevicaulis
    lomentospora prolificans
    in vitro
    fusarium solani
    antifungal combinations
    Saúde coletiva
    Química
    Pharmacology (medical)
    Pharmacology & pharmacy
    Odontología
    Nutrição
    Microbiology (medical)
    Microbiology
    Medicine (miscellaneous)
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Materiais
    Interdisciplinar
    Infectious diseases
    General medicine
    Farmacia
    Engenharias iii
    Engenharias ii
    Enfermagem
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Ciências agrárias i
    Biotecnología
    Biodiversidade
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