Autor según el artículo: Martin-Vicente A, Guarro J, Capilla J

Departamento: Ciències Mèdiques Bàsiques

Autor/es de la URV: Capilla Luque, Javier / Guarro Artigas, Josep

Palabras clave: Transplant recipient Scopulariopsis brumptii Scopulariopsis brevicaulis Scopulariopsis Scedosporium-prolificans Murine model Lomentospora prolificans Invasive aspergillosis In vitro Fusarium solani Fusarium Filamentous fungi Caspofungin Antifungal drugs Antifungal combinations Amphotericin-b scopulariopsis brevicaulis lomentospora prolificans in vitro fusarium solani antifungal combinations

Resumen: In this study, the in vitro interactions of amphotericin B (AmB), voriconazole (VRC) and anidulafungin (AFG) in double and triple combinations against four species of multiresistant fungi (Fusarium solani, Lomentospora prolificans, Scopulariopsis brevicaulis and Scopulariopsis brumptii) were evaluated. In general, AmB combined with AFG was the most synergistic, especially against F. solani (7/8; 87.5%) when low concentrations of AmB were used, i.e. 0.125-0.5 µg/mL. The least active combination was AmB + VRC, with the lowest percentage of synergy against S. brevicaulis (2/11; 18.2%) and, in general, high concentrations of both antifungals were needed to achieve synergy. The triple combination was also highly synergistic against F. solani and S. brevicaulis, especially when the lowest concentrations of AmB were used, suggesting that use of combined therapies would reduce the toxicity of therapy. The triple combination was more effective than the double combinations in some cases, but not against all strains, suggesting that administration of three drugs is not always useful in the treatment of infections due to multiresistant fungi.

Áreas temáticas: Saúde coletiva Química Pharmacology (medical) Pharmacology & pharmacy Odontología Nutrição Microbiology (medical) Microbiology Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Infectious diseases General medicine Farmacia Engenharias iii Engenharias ii Enfermagem Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Biotecnología Biodiversidade

Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 09248579

Direcció de correo del autor: josep.guarro@urv.cat javier.capilla@urv.cat

Identificador del autor: 0000-0002-7839-7568 0000-0002-0765-6403

Fecha de alta del registro: 2023-02-18

Versión del articulo depositado: info:eu-repo/semantics/acceptedVersion

Enlace a la fuente original: https://www.sciencedirect.com/science/article/abs/pii/S0924857917300614?via%3Dihub

URL Documento de licencia: http://repositori.urv.cat/ca/proteccio-de-dades/

Referencia al articulo segun fuente origial: International Journal Of Antimicrobial Agents. 49 (4): 422-426

Referencia de l'ítem segons les normes APA: Martin-Vicente A, Guarro J, Capilla J (2017). Does a triple combination have better activity than double combinations against multiresistant fungi? Experimental in vitro evaluation.. International Journal Of Antimicrobial Agents, 49(4), 422-426. DOI: 10.1016/j.ijantimicag.2016.12.015

DOI del artículo: 10.1016/j.ijantimicag.2016.12.015

Entidad: Universitat Rovira i Virgili

Año de publicación de la revista: 2017

Tipo de publicación: Journal Publications