Autor segons l'article: Karoutzou O, Kwak SH, Lee SD, Martínez-Falguera D, Sureda FX, Vázquez S, Kim YC, Barniol-Xicota M
Departament: Ciències Mèdiques Bàsiques
e-ISSN: 1420-3049
Autor/s de la URV: Sureda Batlle, Francesc Xavier
Paraules clau: P2x7 Nmda Neuroinflammation Dual target compounds Alzheimer’s disease p2x7 nmda dual target compounds alzheimer’s disease
Resum: Multi-target-directed ligands (MTDLs) offer new hope for the treatment of multifactorial complex diseases such as Alzheimer's Disease (AD). Herein, we present compounds aimed at targeting the NMDA and the P2X7 receptors, which embody a different approach to AD therapy. On one hand, we are seeking to delay neurodegeneration targeting the glutamatergic NMDA receptors; on the other hand, we also aim to reduce neuroinflammation, targeting P2X7 receptors. Although the NMDA receptor is a widely recognized therapeutic target in treating AD, the P2X7 receptor remains largely unexplored for this purpose; therefore, the dual inhibitor presented herein¿which is open to further optimization¿represents the first member of a new class of MTDLs
Àrees temàtiques: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Planejamento urbano e regional / demografia Physical and theoretical chemistry Pharmaceutical science Organic chemistry Odontología Nutrição Molecular medicine Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Matemática / probabilidade e estatística Interdisciplinar Geografía General medicine Farmacia Ensino Engenharias iv Engenharias iii Engenharias ii Engenharias i Educação física Economia Drug discovery Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Ciência da computação Chemistry, organic Chemistry, multidisciplinary Chemistry (miscellaneous) Biotecnología Biodiversidade Biochemistry & molecular biology Astronomia / física Analytical chemistry
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 14203049
Adreça de correu electrònic de l'autor: francesc.sureda@urv.cat
Identificador de l'autor: 0000-0002-7968-3929
Data d'alta del registre: 2024-09-07
Volum de revista: 23
Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
Enllaç font original: https://www.mdpi.com/1420-3049/23/1/230
URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
Referència a l'article segons font original: Molecules. 23 (1):
Referència de l'ítem segons les normes APA: Karoutzou O, Kwak SH, Lee SD, Martínez-Falguera D, Sureda FX, Vázquez S, Kim YC, Barniol-Xicota M (2018). Towards a Novel Class of Multitarget-Directed Ligands: Dual P2X7-NMDA Receptor Antagonists. Molecules, 23(1), -. DOI: 10.3390/molecules23010230
DOI de l'article: 10.3390/molecules23010230
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2018
Tipus de publicació: Journal Publications
Repositori URV