Towards a Novel Class of Multitarget-Directed Ligands: Dual P2X7-NMDA Receptor Antagonists

Autor segons l'article: Karoutzou, Olga; Kwak, Seung-Hwa; Lee, So-Deok; Martinez-Falguera, Daina; Sureda, Francesc X; Vazquez, Santiago; Kim, Yong-Chul; Barniol-Xicota, Marta

Departament: Ciències Mèdiques Bàsiques

e-ISSN: 1420-3049

Autor/s de la URV: Sureda Batlle, Francesc Xavier

Paraules clau: Receptors, purinergic p2x; Purinergic p2x receptor antagonists; P2x7; Nmda; Neuroinflammation; Molecular structure; Ligands; Inhibitory concentration 50; Humans; Dual target compounds; Drug discovery; Drug design; Dose-response relationship, drug; Chemistry techniques, synthetic; Cell line, tumor; Alzheimer’s disease; Alzheimer disease; p2x7; nmda; dual target compounds; alzheimer’s disease

Resum: Multi-target-directed ligands (MTDLs) offer new hope for the treatment of multifactorial complex diseases such as Alzheimer's Disease (AD). Herein, we present compounds aimed at targeting the NMDA and the P2X7 receptors, which embody a different approach to AD therapy. On one hand, we are seeking to delay neurodegeneration targeting the glutamatergic NMDA receptors; on the other hand, we also aim to reduce neuroinflammation, targeting P2X7 receptors. Although the NMDA receptor is a widely recognized therapeutic target in treating AD, the P2X7 receptor remains largely unexplored for this purpose; therefore, the dual inhibitor presented herein¿which is open to further optimization¿represents the first member of a new class of MTDLs

Àrees temàtiques: Zootecnia / recursos pesqueiros; Saúde coletiva; Química; Psicología; Planejamento urbano e regional / demografia; Physical and theoretical chemistry; Pharmaceutical science; Organic chemistry; Odontología; Nutrição; Molecular medicine; Medicine (miscellaneous); Medicina veterinaria; Medicina iii; Medicina ii; Medicina i; Materiais; Matemática / probabilidade e estatística; Interdisciplinar; Geografía; General medicine; Farmacia; Ensino; Engenharias iv; Engenharias iii; Engenharias ii; Engenharias i; Educação física; Economia; Drug discovery; Ciências biológicas iii; Ciências biológicas ii; Ciências biológicas i; Ciências ambientais; Ciências agrárias i; Ciência de alimentos; Ciência da computação; Chemistry, organic; Chemistry, multidisciplinary; Chemistry (miscellaneous); Biotecnología; Biodiversidade; Biochemistry & molecular biology; Astronomia / física; Analytical chemistry

Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 14203049

Adreça de correu electrònic de l'autor: francesc.sureda@urv.cat

Data d'alta del registre: 2025-02-18

Volum de revista: 23

Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion

Enllaç font original: https://www.mdpi.com/1420-3049/23/1/230

URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/

Referència a l'article segons font original: Molecules. 23 (1): 230-

Referència de l'ítem segons les normes APA: Karoutzou, Olga; Kwak, Seung-Hwa; Lee, So-Deok; Martinez-Falguera, Daina; Sureda, Francesc X; Vazquez, Santiago; Kim, Yong-Chul; Barniol-Xicota, Marta (2018). Towards a Novel Class of Multitarget-Directed Ligands: Dual P2X7-NMDA Receptor Antagonists. Molecules, 23(1), 230-. DOI: 10.3390/molecules23010230

DOI de l'article: 10.3390/molecules23010230

Entitat: Universitat Rovira i Virgili

Any de publicació de la revista: 2018

Tipus de publicació: Journal Publications