Articles producció científicaCiències Mèdiques Bàsiques

Towards a Novel Class of Multitarget-Directed Ligands: Dual P2X7-NMDA Receptor Antagonists

  • Identification data

    Identifier:  imarina:5132137
    Handle: https://hdl.handle.net/20.500.11797/imarina5132137
    Authors:  Karoutzou, O; Kwak, SH; Lee, SD; Martínez-Falguera, D; Sureda, FX; Vázquez, S; Kim, YC; Barniol-Xicota, M
    Abstract:
    Multi-target-directed ligands (MTDLs) offer new hope for the treatment of multifactorial complex diseases such as Alzheimer's Disease (AD). Herein, we present compounds aimed at targeting the NMDA and the P2X7 receptors, which embody a different approach to AD therapy. On one hand, we are seeking to delay neurodegeneration targeting the glutamatergic NMDA receptors; on the other hand, we also aim to reduce neuroinflammation, targeting P2X7 receptors. Although the NMDA receptor is a widely recognized therapeutic target in treating AD, the P2X7 receptor remains largely unexplored for this purpose; therefore, the dual inhibitor presented herein¿which is open to further optimization¿represents the first member of a new class of MTDLs

  • Others:

    Link to the original source: https://www.mdpi.com/1420-3049/23/1/230
    APA: Karoutzou, O; Kwak, SH; Lee, SD; Martínez-Falguera, D; Sureda, FX; Vázquez, S; Kim, YC; Barniol-Xicota, M (2018). Towards a Novel Class of Multitarget-Directed Ligands: Dual P2X7-NMDA Receptor Antagonists. MOLECULES, 23(1), 230-. DOI: 10.3390/molecules23010230
    Paper original source: MOLECULES. 23 (1): 230-
    Article's DOI: 10.3390/molecules23010230
    Journal publication year: 2018-01-01
    Entity: Universitat Rovira i Virgili
    Paper version: info:eu-repo/semantics/publishedVersion
    Record's date: 2026-05-09
    URV's Author/s: Sureda Batlle, Francesc Xavier
    Department: Ciències Mèdiques Bàsiques
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Publication Type: Journal Publications
    ISSN: 14203049
    Author, as appears in the article.: Karoutzou, O; Kwak, SH; Lee, SD; Martínez-Falguera, D; Sureda, FX; Vázquez, S; Kim, YC; Barniol-Xicota, M
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Journal volume: 23
    e-ISSN: 1420-3049
    Thematic Areas: Physical and theoretical chemistry, Pharmaceutical science, Organic chemistry, Molecular medicine, Medicine (miscellaneous), General medicine, Drug discovery, Ciências ambientais, Ciências agrárias i, Chemistry, organic, Chemistry, multidisciplinary, Chemistry (miscellaneous), Biochemistry & molecular biology, Analytical chemistry, Administração pública e de empresas, ciências contábeis e turismo
    Author's mail: francesc.sureda@urv.cat, francesc.sureda@urv.cat

  • Keywords:

    Receptors
    purinergic p2x
    Purinergic p2x receptor antagonists
    P2x7
    Nmda
    Neuroinflammation
    Molecular structure
    Ligands
    Inhibitory concentration 50
    Humans
    Dual target compounds
    Drug discovery
    Drug design
    Dose-response relationship
    drug
    Chemistry techniques
    synthetic
    Cell line
    tumor
    Alzheimer’s disease
    Alzheimer disease
    Analytical Chemistry
    Biochemistry & Molecular Biology
    Chemistry (Miscellaneous)
    Chemistry
    Multidisciplinary
    Organic
    Medicine (Miscellaneous)
    Molecular Medicine
    Organic Chemistry
    Pharmaceutical Science
    Physical and Theoretical Chemistry
    General medicine
    Ciências ambientais
    Ciências agrárias i
    Administração pública e de empresas
    ciências contábeis e turismo

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