Author, as appears in the article.: Karoutzou, Olga; Kwak, Seung-Hwa; Lee, So-Deok; Martinez-Falguera, Daina; Sureda, Francesc X; Vazquez, Santiago; Kim, Yong-Chul; Barniol-Xicota, Marta
Department: Ciències Mèdiques Bàsiques
e-ISSN: 1420-3049
URV's Author/s: Sureda Batlle, Francesc Xavier
Keywords: Receptors, purinergic p2x; Purinergic p2x receptor antagonists; P2x7; Nmda; Neuroinflammation; Molecular structure; Ligands; Inhibitory concentration 50; Humans; Dual target compounds; Drug discovery; Drug design; Dose-response relationship, drug; Chemistry techniques, synthetic; Cell line, tumor; Alzheimer’s disease; Alzheimer disease; p2x7; nmda; dual target compounds; alzheimer’s disease
Abstract: Multi-target-directed ligands (MTDLs) offer new hope for the treatment of multifactorial complex diseases such as Alzheimer's Disease (AD). Herein, we present compounds aimed at targeting the NMDA and the P2X7 receptors, which embody a different approach to AD therapy. On one hand, we are seeking to delay neurodegeneration targeting the glutamatergic NMDA receptors; on the other hand, we also aim to reduce neuroinflammation, targeting P2X7 receptors. Although the NMDA receptor is a widely recognized therapeutic target in treating AD, the P2X7 receptor remains largely unexplored for this purpose; therefore, the dual inhibitor presented herein¿which is open to further optimization¿represents the first member of a new class of MTDLs
Thematic Areas: Zootecnia / recursos pesqueiros; Saúde coletiva; Química; Psicología; Planejamento urbano e regional / demografia; Physical and theoretical chemistry; Pharmaceutical science; Organic chemistry; Odontología; Nutrição; Molecular medicine; Medicine (miscellaneous); Medicina veterinaria; Medicina iii; Medicina ii; Medicina i; Materiais; Matemática / probabilidade e estatística; Interdisciplinar; Geografía; General medicine; Farmacia; Ensino; Engenharias iv; Engenharias iii; Engenharias ii; Engenharias i; Educação física; Economia; Drug discovery; Ciências biológicas iii; Ciências biológicas ii; Ciências biológicas i; Ciências ambientais; Ciências agrárias i; Ciência de alimentos; Ciência da computação; Chemistry, organic; Chemistry, multidisciplinary; Chemistry (miscellaneous); Biotecnología; Biodiversidade; Biochemistry & molecular biology; Astronomia / física; Analytical chemistry
licence for use: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 14203049
Author's mail: francesc.sureda@urv.cat
Record's date: 2025-02-18
Journal volume: 23
Paper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://www.mdpi.com/1420-3049/23/1/230
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Paper original source: Molecules. 23 (1): 230-
APA: Karoutzou, Olga; Kwak, Seung-Hwa; Lee, So-Deok; Martinez-Falguera, Daina; Sureda, Francesc X; Vazquez, Santiago; Kim, Yong-Chul; Barniol-Xicota, Marta (2018). Towards a Novel Class of Multitarget-Directed Ligands: Dual P2X7-NMDA Receptor Antagonists. Molecules, 23(1), 230-. DOI: 10.3390/molecules23010230
Article's DOI: 10.3390/molecules23010230
Entity: Universitat Rovira i Virgili
Journal publication year: 2018
Publication Type: Journal Publications
Repositori URV