Articles producció científica> Medicina i Cirurgia

Gut Microbiota-Derived Mediators as Potential Markers in Nonalcoholic Fatty Liver Disease

  • Dades identificatives

    Identificador: imarina:5132827
    Autors:
    Aragones, GemmaGonzalez-Garcia, SergioAguilar, CarmenRichart, CristobalAuguet, Teresa
    Resum:
    Nonalcoholic fatty liver disease (NAFLD) is a common, multifactorial, and poorly understood liver disease whose incidence is globally rising. During the past decade, several lines of evidence suggest that dysbiosis of intestinal microbiome represents an important factor contributing to NAFLD occurrence and its progression into NASH. The mechanisms that associate dysbiosis with NAFLD include changes in microbiota-derived mediators, deregulation of the gut endothelial barrier, translocation of mediators of dysbiosis, and hepatic inflammation. Changes in short chain fatty acids, bile acids, bacterial components, choline, and ethanol are the result of altered intestinal microbiota. We perform a narrative review of the previously published evidence and discuss the use of gut microbiota-derived mediators as potential markers in NAFLD.
  • Altres:

    Autor segons l'article: Aragones, Gemma; Gonzalez-Garcia, Sergio; Aguilar, Carmen; Richart, Cristobal; Auguet, Teresa
    Departament: Medicina i Cirurgia
    Autor/s de la URV: Aguilar Crespillo, Carmen Isabel / ARAGONÈS BARGALLÓ, GEMMA / Auguet Quintillà, Maria Teresa / Richart Jurado, Cristobal Manuel
    Paraules clau: Trimethylamine-n-oxide Tnf-alpha Steatohepatitis Receptor Plasma-levels Obese-patients Non-alcoholic fatty liver disease Increased intestinal permeability Humans Gastrointestinal microbiome Fatty acids, volatile Biomarkers Bile-acids induce Bile acids and salts Animals Alpha gene Activation
    Resum: Nonalcoholic fatty liver disease (NAFLD) is a common, multifactorial, and poorly understood liver disease whose incidence is globally rising. During the past decade, several lines of evidence suggest that dysbiosis of intestinal microbiome represents an important factor contributing to NAFLD occurrence and its progression into NASH. The mechanisms that associate dysbiosis with NAFLD include changes in microbiota-derived mediators, deregulation of the gut endothelial barrier, translocation of mediators of dysbiosis, and hepatic inflammation. Changes in short chain fatty acids, bile acids, bacterial components, choline, and ethanol are the result of altered intestinal microbiota. We perform a narrative review of the previously published evidence and discuss the use of gut microbiota-derived mediators as potential markers in NAFLD.
    Àrees temàtiques: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Odontología Nutrição Medicine, research & experimental Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Matemática / probabilidade e estatística Interdisciplinar Immunology and microbiology (miscellaneous) Immunology and microbiology (all) Geografía General immunology and microbiology General biochemistry,genetics and molecular biology Farmacia Ensino Engenharias iv Engenharias iii Engenharias ii Engenharias i Enfermagem Educação física Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Ciência da computação Biotecnología Biotechnology & applied microbiology Biodiversidade Biochemistry, genetics and molecular biology (miscellaneous) Biochemistry, genetics and molecular biology (all) Astronomia / física Antropologia / arqueologia
    Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 23146133
    Adreça de correu electrònic de l'autor: carmenisabel.aguilar@urv.cat carmenisabel.aguilar@urv.cat mariateresa.auguet@urv.cat
    Identificador de l'autor: 0000-0002-4440-562X 0000-0002-4440-562X 0000-0003-0396-6428
    Data d'alta del registre: 2024-09-28
    Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
    Enllaç font original: https://www.hindawi.com/journals/bmri/2019/8507583/
    URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referència a l'article segons font original: Biomed Research International. 2019 8507583-
    Referència de l'ítem segons les normes APA: Aragones, Gemma; Gonzalez-Garcia, Sergio; Aguilar, Carmen; Richart, Cristobal; Auguet, Teresa (2019). Gut Microbiota-Derived Mediators as Potential Markers in Nonalcoholic Fatty Liver Disease. Biomed Research International, 2019(), 8507583-. DOI: 10.1155/2019/8507583
    DOI de l'article: 10.1155/2019/8507583
    Entitat: Universitat Rovira i Virgili
    Any de publicació de la revista: 2019
    Tipus de publicació: Journal Publications
  • Paraules clau:

    Biochemistry, Genetics and Molecular Biology (Miscellaneous),Biotechnology & Applied Microbiology,Immunology and Microbiology (Miscellaneous),Medicine (Miscellaneous),Medicine, Research & Experimental
    Trimethylamine-n-oxide
    Tnf-alpha
    Steatohepatitis
    Receptor
    Plasma-levels
    Obese-patients
    Non-alcoholic fatty liver disease
    Increased intestinal permeability
    Humans
    Gastrointestinal microbiome
    Fatty acids, volatile
    Biomarkers
    Bile-acids induce
    Bile acids and salts
    Animals
    Alpha gene
    Activation
    Zootecnia / recursos pesqueiros
    Saúde coletiva
    Química
    Psicología
    Odontología
    Nutrição
    Medicine, research & experimental
    Medicine (miscellaneous)
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Materiais
    Matemática / probabilidade e estatística
    Interdisciplinar
    Immunology and microbiology (miscellaneous)
    Immunology and microbiology (all)
    Geografía
    General immunology and microbiology
    General biochemistry,genetics and molecular biology
    Farmacia
    Ensino
    Engenharias iv
    Engenharias iii
    Engenharias ii
    Engenharias i
    Enfermagem
    Educação física
    Economia
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Ciências agrárias i
    Ciência de alimentos
    Ciência da computação
    Biotecnología
    Biotechnology & applied microbiology
    Biodiversidade
    Biochemistry, genetics and molecular biology (miscellaneous)
    Biochemistry, genetics and molecular biology (all)
    Astronomia / física
    Antropologia / arqueologia
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