Autor segons l'article: Hellmuth C, Uhl O, Kirchberg FF, Grote V, Weber M, Rzehak P, Carlier C, Ferre N, Verduci E, Gruszfeld D, Socha P, Koletzko B, European Childhood Obesity Trial Study Group.
Departament: Medicina i Cirurgia
Autor/s de la URV: Closa Monasterolo, Ricardo / Escribano Subías, Joaquín / Ferre Pallas, Natalia / Luque Moreno, Verònica
Paraules clau: Zero hunger
Resum: Breastfeeding induces a different metabolic and endocrine response than feeding conventional infant formula, and it has also been associated with slower weight gain and reduced disease risk in later life. The underlying programming mechanisms remain to be explored. Breastfeeding has been reported to induce lower levels of insulin, insulin-like growth factor-1 and some amino acids (AAs) than formula feeding. In the Childhood Obesity Project (CHOP), infants fed a conventional protein-rich formula had a higher BMI at 2 and 6 years than those fed a protein-reduced formula. At 6 months, higher protein intakes induced increased plasma concentrations of branched-chain AAs (BCAAs) and their oxidation products, short-chain acylcarnitines. With increasing BCAA levels, these short-chain acylcarnitines increased proportionally only until a break point was reached, after which BCAAs seemed to escape their degradation. The resulting marked elevation in BCAA levels with high-protein (HP) intakes appears to contribute to increased insulin levels and to affect β-oxidation of fatty acids. The ratios of long-chain acylcarnitines to free carnitine decreased in infants who received a HP formula, which indicates a reduced initiation of β-oxidation. We conclude that HP intakes inducing high BCAA plasma levels may inhibit fat oxidation and thereby enhance body fat deposition and adiposity.
Àrees temàtiques: Pediatrics, perinatology and child health Nutrition and dietetics Medicine (miscellaneous) Medicine (all) Food science
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
Adreça de correu electrònic de l'autor: veronica.luque@urv.cat ricardo.closa@urv.cat natalia.ferre@urv.cat joaquin.escribano@urv.cat
Identificador de l'autor: 0000-0003-2615-8175 0000-0002-9963-4163 0000-0002-2838-1525 0000-0002-5041-459X
Data d'alta del registre: 2024-11-16
Versió de l'article dipositat: info:eu-repo/semantics/submittedVersion
Enllaç font original: https://www.karger.com/Article/Abstract/439491
URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
Referència a l'article segons font original: Nestle Nutrition Institute Workshop Series. 85 89-100
Referència de l'ítem segons les normes APA: Hellmuth C, Uhl O, Kirchberg FF, Grote V, Weber M, Rzehak P, Carlier C, Ferre N, Verduci E, Gruszfeld D, Socha P, Koletzko B, European Childhood Obesi (2016). Effects of early nutrition on the infant metabolome.. Nestle Nutrition Institute Workshop Series, 85(), 89-100. DOI: 10.1159/000439491
DOI de l'article: 10.1159/000439491
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2016
Tipus de publicació: Journal Publications