Articles producció científica> Medicina i Cirurgia

Effects of early nutrition on the infant metabolome.

  • Dades identificatives

    Identificador: imarina:5133059
    Autors:
    Hellmuth C, Uhl O, Kirchberg FF, Grote V, Weber M, Rzehak P, Carlier C, Ferre N, Verduci E, Gruszfeld D, Socha P, Koletzko B, European Childhood Obesity Trial Study Group.
    Resum:
    Breastfeeding induces a different metabolic and endocrine response than feeding conventional infant formula, and it has also been associated with slower weight gain and reduced disease risk in later life. The underlying programming mechanisms remain to be explored. Breastfeeding has been reported to induce lower levels of insulin, insulin-like growth factor-1 and some amino acids (AAs) than formula feeding. In the Childhood Obesity Project (CHOP), infants fed a conventional protein-rich formula had a higher BMI at 2 and 6 years than those fed a protein-reduced formula. At 6 months, higher protein intakes induced increased plasma concentrations of branched-chain AAs (BCAAs) and their oxidation products, short-chain acylcarnitines. With increasing BCAA levels, these short-chain acylcarnitines increased proportionally only until a break point was reached, after which BCAAs seemed to escape their degradation. The resulting marked elevation in BCAA levels with high-protein (HP) intakes appears to contribute to increased insulin levels and to affect β-oxidation of fatty acids. The ratios of long-chain acylcarnitines to free carnitine decreased in infants who received a HP formula, which indicates a reduced initiation of β-oxidation. We conclude that HP intakes inducing high BCAA plasma levels may inhibit fat oxidation and thereby enhance body fat deposition and adiposity.
  • Altres:

    Autor segons l'article: Hellmuth C, Uhl O, Kirchberg FF, Grote V, Weber M, Rzehak P, Carlier C, Ferre N, Verduci E, Gruszfeld D, Socha P, Koletzko B, European Childhood Obesity Trial Study Group.
    Departament: Medicina i Cirurgia
    Autor/s de la URV: Closa Monasterolo, Ricardo / Escribano Subías, Joaquín / Ferre Pallas, Natalia / Luque Moreno, Verònica
    Paraules clau: @infoAeu @residentesaeu @uroweb Etiqueta «#» Hashtag
    Resum: Breastfeeding induces a different metabolic and endocrine response than feeding conventional infant formula, and it has also been associated with slower weight gain and reduced disease risk in later life. The underlying programming mechanisms remain to be explored. Breastfeeding has been reported to induce lower levels of insulin, insulin-like growth factor-1 and some amino acids (AAs) than formula feeding. In the Childhood Obesity Project (CHOP), infants fed a conventional protein-rich formula had a higher BMI at 2 and 6 years than those fed a protein-reduced formula. At 6 months, higher protein intakes induced increased plasma concentrations of branched-chain AAs (BCAAs) and their oxidation products, short-chain acylcarnitines. With increasing BCAA levels, these short-chain acylcarnitines increased proportionally only until a break point was reached, after which BCAAs seemed to escape their degradation. The resulting marked elevation in BCAA levels with high-protein (HP) intakes appears to contribute to increased insulin levels and to affect β-oxidation of fatty acids. The ratios of long-chain acylcarnitines to free carnitine decreased in infants who received a HP formula, which indicates a reduced initiation of β-oxidation. We conclude that HP intakes inducing high BCAA plasma levels may inhibit fat oxidation and thereby enhance body fat deposition and adiposity.
    Àrees temàtiques: Pediatrics, perinatology and child health Nutrition and dietetics Medicine (miscellaneous) Medicine (all) Food science
    Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
    Adreça de correu electrònic de l'autor: veronica.luque@urv.cat joaquin.escribano@urv.cat natalia.ferre@urv.cat ricardo.closa@urv.cat
    Identificador de l'autor: 0000-0003-2615-8175 0000-0002-5041-459X 0000-0002-2838-1525 0000-0002-9963-4163
    Data d'alta del registre: 2023-07-31
    Versió de l'article dipositat: info:eu-repo/semantics/submittedVersion
    Enllaç font original: https://www.karger.com/Article/Abstract/439491
    Referència a l'article segons font original: Nestle Nutrition Institute Workshop Series. 85 89-100
    Referència de l'ítem segons les normes APA: Hellmuth C, Uhl O, Kirchberg FF, Grote V, Weber M, Rzehak P, Carlier C, Ferre N, Verduci E, Gruszfeld D, Socha P, Koletzko B, European Childhood Obesi (2016). Effects of early nutrition on the infant metabolome.. Nestle Nutrition Institute Workshop Series, 85(), 89-100. DOI: 10.1159/000439491
    URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
    DOI de l'article: 10.1159/000439491
    Entitat: Universitat Rovira i Virgili
    Any de publicació de la revista: 2016
    Tipus de publicació: Journal Publications
  • Paraules clau:

    Food Science,Medicine (Miscellaneous),Nutrition and Dietetics,Pediatrics, Perinatology and Child Health
    Pediatrics, perinatology and child health
    Nutrition and dietetics
    Medicine (miscellaneous)
    Medicine (all)
    Food science
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