Autor segons l'article: Halu, Arda; De Domenico, Manlio; Arenas, Alex; Sharma, Amitabh
Departament: Enginyeria Informàtica i Matemàtiques
Autor/s de la URV: Arenas Moreno, Alejandro / DE DOMENICO, MANLIO
Paraules clau: Systems biology Phenotype Ontology Online mendelian inheritance Maps Humans Genotype Gene regulatory networks Disease Computational biology and bioinformatics Computational biology Community structure Biology
Resum: Untangling the complex interplay between phenotype and genotype is crucial to the effective characterization and subtyping of diseases. Here we build and analyze the multiplex network of 779 human diseases, which consists of a genotype-based layer and a phenotype-based layer. We show that diseases with common genetic constituents tend to share symptoms, and uncover how phenotype information helps boost genotype information. Moreover, we offer a flexible classification of diseases that considers their molecular underpinnings alongside their clinical manifestations. We detect cohesive groups of diseases that have high intra-group similarity at both the molecular and the phenotypic level. Inspecting these disease communities, we demonstrate the underlying pathways that connect diseases mechanistically. We observe monogenic disorders grouped together with complex diseases for which they increase the risk factor. We propose potentially new disease associations that arise as a unique feature of the information flow within and across the two layers.
Àrees temàtiques: Modeling and simulation Mathematical & computational biology General biochemistry,genetics and molecular biology Drug discovery Computer science applications Biochemistry, genetics and molecular biology (miscellaneous) Biochemistry, genetics and molecular biology (all) Applied mathematics
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 20567189
Adreça de correu electrònic de l'autor: alexandre.arenas@urv.cat
Identificador de l'autor: 0000-0003-0937-0334
Data d'alta del registre: 2024-09-28
Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
Enllaç font original: https://www.nature.com/articles/s41540-019-0092-5
URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
Referència a l'article segons font original: Npj Syst Biol Appl. 5 (UNSP 15): 15-15
Referència de l'ítem segons les normes APA: Halu, Arda; De Domenico, Manlio; Arenas, Alex; Sharma, Amitabh (2019). The multiplex network of human diseases. Npj Syst Biol Appl, 5(UNSP 15), 15-15. DOI: 10.1038/s41540-019-0092-5
DOI de l'article: 10.1038/s41540-019-0092-5
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2019
Tipus de publicació: Journal Publications