Articles producció científica> Enginyeria Química

Prenatal exposure to PFOS and PFOA in a pregnant women cohort of Catalonia, Spain

  • Dades identificatives

    Identificador: imarina:5643791
    Autors:
    Rovira, JoaquimAngeles Martinez, MariaPrasad Sharma, RajuEspuis, TeresaNadal, MartiKumar, VikasCostopoulou, DanaeVassiliadou, IreneLeondiadis, LeondiosDomingo, Jose LSchuhmacher, Marta
    Resum:
    © 2019 Elsevier Inc. This study was aimed at assessing the prenatal exposure to perfluorooctane sulfonic acid (PFOS) and perfluorooctanoic acid (PFOA) in a cohort of pregnant women living in Reus (Tarragona County, Catalonia, Spain). These chemicals were biomonitored in maternal plasma during the first trimester of pregnancy, at delivery, and in cord blood. The dietary exposure of PFOS and PFOA was estimated by using questionnaires of food frequency and water intake, as well as data on food levels previously reported in the same area. In addition, the exposure through air inhalation and indoor dust ingestion was also calculated. Finally, a physiologically-based pharmacokinetic (PBPK) model was applied in order to establish the prenatal exposure of the fetus/child and to adjust exposure assessment vs. biomonitoring results. Probabilistic calculations of fetal exposure were performed by forward internal dosimetry and Monte-Carlo simulation. Mean plasma levels of PFOA were 0.45, 0.13 and 0.12 ng/mL at the first trimester, at delivery and in cord plasma, while those of PFOS were 2.93, 2.21, and 1.17 ng/mL, respectively. Traces of PFOS were found in all samples in the trimester and at delivery, and almost in all cord blood samples. Transplacental transfers of PFOS and PFOA were estimated to be around 70% and 60%, respectively. A temporal decrease trend in plasma levels of PFOS and PFOA was noticed, when comparing current values with data obtained 10 years ago in the same area. In agreement with many other studies, dietary intake was the main route of exposure to PFOS and PFOA in our cohort of pregnant women. It is an important issue to establish the exposure in critical windows periods such as fetal development to perfluoroalkylated substances, but also to other endocrine di
  • Altres:

    Autor segons l'article: Rovira, Joaquim; Angeles Martinez, Maria; Prasad Sharma, Raju; Espuis, Teresa; Nadal, Marti; Kumar, Vikas; Costopoulou, Danae; Vassiliadou, Irene; Leondiadis, Leondios; Domingo, Jose L; Schuhmacher, Marta
    Departament: Ciències Mèdiques Bàsiques Enginyeria Química
    Autor/s de la URV: Domingo Roig, José Luis / Kumar, Vikas / Martínez Rodríguez, María Ángeles / Nadal Lomas, Martí / Rovira Solano, Joaquim / Schuhmacher Ansuategui, Marta
    Paraules clau: Spain Serum concentrations Prenatal exposure delayed effects Prenatal exposure Pregnancy Polyfluoroalkyl substances Plasma Pfos Pfoa Persistent organic pollutants Perfluorooctanoic acid Perfluoroalkyl substances Perfluorinated compounds Pbpk modeling Maternal exposure Humans Health-risks Fluorocarbons Female Environmental exposure Drinking-water Dietary intake Dietary exposure Cord blood Child Caprylates Birth cohort Alkanesulfonic acids plasma pfos pfoa pbpk modeling dietary intake cord blood
    Resum: © 2019 Elsevier Inc. This study was aimed at assessing the prenatal exposure to perfluorooctane sulfonic acid (PFOS) and perfluorooctanoic acid (PFOA) in a cohort of pregnant women living in Reus (Tarragona County, Catalonia, Spain). These chemicals were biomonitored in maternal plasma during the first trimester of pregnancy, at delivery, and in cord blood. The dietary exposure of PFOS and PFOA was estimated by using questionnaires of food frequency and water intake, as well as data on food levels previously reported in the same area. In addition, the exposure through air inhalation and indoor dust ingestion was also calculated. Finally, a physiologically-based pharmacokinetic (PBPK) model was applied in order to establish the prenatal exposure of the fetus/child and to adjust exposure assessment vs. biomonitoring results. Probabilistic calculations of fetal exposure were performed by forward internal dosimetry and Monte-Carlo simulation. Mean plasma levels of PFOA were 0.45, 0.13 and 0.12 ng/mL at the first trimester, at delivery and in cord plasma, while those of PFOS were 2.93, 2.21, and 1.17 ng/mL, respectively. Traces of PFOS were found in all samples in the trimester and at delivery, and almost in all cord blood samples. Transplacental transfers of PFOS and PFOA were estimated to be around 70% and 60%, respectively. A temporal decrease trend in plasma levels of PFOS and PFOA was noticed, when comparing current values with data obtained 10 years ago in the same area. In agreement with many other studies, dietary intake was the main route of exposure to PFOS and PFOA in our cohort of pregnant women. It is an important issue to establish the exposure in critical windows periods such as fetal development to perfluoroalkylated substances, but also to other endocrine disrupting chemicals.
    Àrees temàtiques: Zootecnia / recursos pesqueiros Saúde coletiva Química Public, environmental & occupational health Public health, environmental and occupational health Psicología Planejamento urbano e regional / demografia Odontología Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Geociências General medicine General environmental science Farmacia Environmental sciences Environmental science (miscellaneous) Environmental science (all) Ensino Engenharias iii Engenharias ii Engenharias i Enfermagem Educação física Direito Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Biotecnología Biodiversidade Biochemistry Astronomia / física
    Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 00139351
    Adreça de correu electrònic de l'autor: vikas.kumar@urv.cat mangeles.martinez@urv.cat joaquim.rovira@urv.cat joseluis.domingo@urv.cat marti.nadal@urv.cat marta.schuhmacher@urv.cat
    Identificador de l'autor: 0000-0002-9795-5967 0000-0001-8595-3772 0000-0003-4399-6138 0000-0001-6647-9470 0000-0002-0217-4827 0000-0003-4381-2490
    Data d'alta del registre: 2024-10-12
    Versió de l'article dipositat: info:eu-repo/semantics/acceptedVersion
    Enllaç font original: https://www.sciencedirect.com/science/article/abs/pii/S0013935119302981?via%3Dihub
    URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referència a l'article segons font original: Environmental Research. 175 384-392
    Referència de l'ítem segons les normes APA: Rovira, Joaquim; Angeles Martinez, Maria; Prasad Sharma, Raju; Espuis, Teresa; Nadal, Marti; Kumar, Vikas; Costopoulou, Danae; Vassiliadou, Irene; Leo (2019). Prenatal exposure to PFOS and PFOA in a pregnant women cohort of Catalonia, Spain. Environmental Research, 175(), 384-392. DOI: 10.1016/j.envres.2019.05.040
    DOI de l'article: 10.1016/j.envres.2019.05.040
    Entitat: Universitat Rovira i Virgili
    Any de publicació de la revista: 2019
    Tipus de publicació: Journal Publications
  • Paraules clau:

    Biochemistry,Environmental Science (Miscellaneous),Environmental Sciences,Public, Environmental & Occupational Health
    Spain
    Serum concentrations
    Prenatal exposure delayed effects
    Prenatal exposure
    Pregnancy
    Polyfluoroalkyl substances
    Plasma
    Pfos
    Pfoa
    Persistent organic pollutants
    Perfluorooctanoic acid
    Perfluoroalkyl substances
    Perfluorinated compounds
    Pbpk modeling
    Maternal exposure
    Humans
    Health-risks
    Fluorocarbons
    Female
    Environmental exposure
    Drinking-water
    Dietary intake
    Dietary exposure
    Cord blood
    Child
    Caprylates
    Birth cohort
    Alkanesulfonic acids
    plasma
    pfos
    pfoa
    pbpk modeling
    dietary intake
    cord blood
    Zootecnia / recursos pesqueiros
    Saúde coletiva
    Química
    Public, environmental & occupational health
    Public health, environmental and occupational health
    Psicología
    Planejamento urbano e regional / demografia
    Odontología
    Medicina iii
    Medicina ii
    Medicina i
    Materiais
    Interdisciplinar
    Geociências
    General medicine
    General environmental science
    Farmacia
    Environmental sciences
    Environmental science (miscellaneous)
    Environmental science (all)
    Ensino
    Engenharias iii
    Engenharias ii
    Engenharias i
    Enfermagem
    Educação física
    Direito
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Ciências agrárias i
    Ciência de alimentos
    Biotecnología
    Biodiversidade
    Biochemistry
    Astronomia / física
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