Articles producció científica> Medicina i Cirurgia

Complement system and small HDL particles are associated with subclinical atherosclerosis in SLE patients

  • Dades identificatives

    Identificador: imarina:569817
    Autors:
    Parra, SVives, GFerre, RGonzalez, MGuardiola, MRibalta, JCastro, A
    Resum:
    The complement system is involved in the pathogenic course of SLE. These patients exhibit metabolic disturbances in lipoprotein metabolism characterized by a pro-inflammatory status and an accelerated atherosclerosis. The aim of this study is to investigate whether levels of the complement are associated to the presence of subclinical atherosclerosis, lipid and glucose metabolism and inflammatory markers in SLE patients.Sixty-nine consecutive patients with SLE were recruited for the study. Fasting venous blood samples were collected on the same day as the measurements of cIMT were performed. Total plasma lipids and the distribution of subclasses of lipoproteins were analyzed by nuclear magnetic resonance spectroscopy.We found direct correlations between cIMT values and the levels of C3, C4 and CH50. In multivariate analyses, the mean cIMT from the three territories were predicted by age (? = 0.005, 95% CI: 0.002-0.007, P < 0.001) and the functional hemolytic assay of the complement activity CH50 (? = 0.003, 95% CI: 0.001-0.006, P < 0.0013). The complement components were associated with BMI, SBP and levels of glucose. Small, dense HDL particles also correlated with the three complement components C3, C4 and CH50 in bivariate analyses. In multivariate analyses small HDL particles predicted levels of C3: ? = 0.024, 95% CI: 0.013-0.035, P < 0.001; and C4: ? = 0.005, 95% CI: 0.002-0.008, P = 0.006.Activation of the complement system measured by functional assay CH50 is related to subclinical atherosclerosis in quiescent lupus patients and is activated by the small dense HDL particles.Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.
  • Altres:

    Autor segons l'article: Parra, S; Vives, G; Ferre, R; Gonzalez, M; Guardiola, M; Ribalta, J; Castro, A
    Departament: Medicina i Cirurgia
    Autor/s de la URV: Castro Salomó, Antoni / FERRÉ VALLÈS, RAIMON / Guardiola Guionnet, Montserrat / Parra Pérez, Sandra / Ribalta Vives, Josep
    Paraules clau: Small hdl particles Middle aged Male Lupus erythematosus, systemic Lupus Intimal medial thickness Humans Female Etiology Complement Blood Atherosclerosis Adult
    Resum: The complement system is involved in the pathogenic course of SLE. These patients exhibit metabolic disturbances in lipoprotein metabolism characterized by a pro-inflammatory status and an accelerated atherosclerosis. The aim of this study is to investigate whether levels of the complement are associated to the presence of subclinical atherosclerosis, lipid and glucose metabolism and inflammatory markers in SLE patients.Sixty-nine consecutive patients with SLE were recruited for the study. Fasting venous blood samples were collected on the same day as the measurements of cIMT were performed. Total plasma lipids and the distribution of subclasses of lipoproteins were analyzed by nuclear magnetic resonance spectroscopy.We found direct correlations between cIMT values and the levels of C3, C4 and CH50. In multivariate analyses, the mean cIMT from the three territories were predicted by age (? = 0.005, 95% CI: 0.002-0.007, P < 0.001) and the functional hemolytic assay of the complement activity CH50 (? = 0.003, 95% CI: 0.001-0.006, P < 0.0013). The complement components were associated with BMI, SBP and levels of glucose. Small, dense HDL particles also correlated with the three complement components C3, C4 and CH50 in bivariate analyses. In multivariate analyses small HDL particles predicted levels of C3: ? = 0.024, 95% CI: 0.013-0.035, P < 0.001; and C4: ? = 0.005, 95% CI: 0.002-0.008, P = 0.006.Activation of the complement system measured by functional assay CH50 is related to subclinical atherosclerosis in quiescent lupus patients and is activated by the small dense HDL particles.Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.
    Àrees temàtiques: Saúde coletiva Psicología Peripheral vascular disease Odontología Nutrição Medicina iii Medicina ii Medicina i Interdisciplinar General medicine Farmacia Engenharias ii Enfermagem Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciência de alimentos Ciência da computação Cardiology and cardiovascular medicine Cardiac & cardiovascular systems Biotecnología Antropologia / arqueologia
    Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 00219150
    Adreça de correu electrònic de l'autor: josep.ribalta@urv.cat montse.guardiola@urv.cat antoni.castro@urv.cat sandra.parra@urv.cat
    Identificador de l'autor: 0000-0002-8879-4719 0000-0002-9696-7384 0000-0001-5441-6333 0000-0001-9363-6574
    Data d'alta del registre: 2024-02-10
    Versió de l'article dipositat: info:eu-repo/semantics/submittedVersion
    Enllaç font original: https://www.atherosclerosis-journal.com/article/S0021-9150(12)00578-3/fulltext
    Referència a l'article segons font original: Atherosclerosis. 225 (1): 224-230
    Referència de l'ítem segons les normes APA: Parra, S; Vives, G; Ferre, R; Gonzalez, M; Guardiola, M; Ribalta, J; Castro, A (2012). Complement system and small HDL particles are associated with subclinical atherosclerosis in SLE patients. Atherosclerosis, 225(1), 224-230. DOI: 10.1016/j.atherosclerosis.2012.08.029
    URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
    DOI de l'article: 10.1016/j.atherosclerosis.2012.08.029
    Entitat: Universitat Rovira i Virgili
    Any de publicació de la revista: 2012
    Tipus de publicació: Journal Publications
  • Paraules clau:

    Cardiac & Cardiovascular Systems,Cardiology and Cardiovascular Medicine,Peripheral Vascular Disease
    Small hdl particles
    Middle aged
    Male
    Lupus erythematosus, systemic
    Lupus
    Intimal medial thickness
    Humans
    Female
    Etiology
    Complement
    Blood
    Atherosclerosis
    Adult
    Saúde coletiva
    Psicología
    Peripheral vascular disease
    Odontología
    Nutrição
    Medicina iii
    Medicina ii
    Medicina i
    Interdisciplinar
    General medicine
    Farmacia
    Engenharias ii
    Enfermagem
    Educação física
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciência de alimentos
    Ciência da computação
    Cardiology and cardiovascular medicine
    Cardiac & cardiovascular systems
    Biotecnología
    Antropologia / arqueologia
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