Author, as appears in the article.: Parra, S; Vives, G; Ferre, R; Gonzalez, M; Guardiola, M; Ribalta, J; Castro, A
Department: Medicina i Cirurgia
URV's Author/s: Castro Salomó, Antoni / FERRÉ VALLÈS, RAIMON / Guardiola Guionnet, Montserrat / Parra Pérez, Sandra / Ribalta Vives, Josep
Keywords: Small hdl particles Middle aged Male Lupus erythematosus, systemic Lupus Intimal medial thickness Humans Female Etiology Complement Blood Atherosclerosis Adult
Abstract: The complement system is involved in the pathogenic course of SLE. These patients exhibit metabolic disturbances in lipoprotein metabolism characterized by a pro-inflammatory status and an accelerated atherosclerosis. The aim of this study is to investigate whether levels of the complement are associated to the presence of subclinical atherosclerosis, lipid and glucose metabolism and inflammatory markers in SLE patients.Sixty-nine consecutive patients with SLE were recruited for the study. Fasting venous blood samples were collected on the same day as the measurements of cIMT were performed. Total plasma lipids and the distribution of subclasses of lipoproteins were analyzed by nuclear magnetic resonance spectroscopy.We found direct correlations between cIMT values and the levels of C3, C4 and CH50. In multivariate analyses, the mean cIMT from the three territories were predicted by age (? = 0.005, 95% CI: 0.002-0.007, P < 0.001) and the functional hemolytic assay of the complement activity CH50 (? = 0.003, 95% CI: 0.001-0.006, P < 0.0013). The complement components were associated with BMI, SBP and levels of glucose. Small, dense HDL particles also correlated with the three complement components C3, C4 and CH50 in bivariate analyses. In multivariate analyses small HDL particles predicted levels of C3: ? = 0.024, 95% CI: 0.013-0.035, P < 0.001; and C4: ? = 0.005, 95% CI: 0.002-0.008, P = 0.006.Activation of the complement system measured by functional assay CH50 is related to subclinical atherosclerosis in quiescent lupus patients and is activated by the small dense HDL particles.Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.
Thematic Areas: Saúde coletiva Psicología Peripheral vascular disease Odontología Nutrição Medicina iii Medicina ii Medicina i Interdisciplinar General medicine Farmacia Engenharias ii Enfermagem Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciência de alimentos Ciência da computação Cardiology and cardiovascular medicine Cardiac & cardiovascular systems Biotecnología Antropologia / arqueologia
licence for use: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 00219150
Author's mail: josep.ribalta@urv.cat montse.guardiola@urv.cat antoni.castro@urv.cat sandra.parra@urv.cat
Author identifier: 0000-0002-8879-4719 0000-0002-9696-7384 0000-0001-5441-6333 0000-0001-9363-6574
Record's date: 2024-02-10
Papper version: info:eu-repo/semantics/submittedVersion
Link to the original source: https://www.atherosclerosis-journal.com/article/S0021-9150(12)00578-3/fulltext
Papper original source: Atherosclerosis. 225 (1): 224-230
APA: Parra, S; Vives, G; Ferre, R; Gonzalez, M; Guardiola, M; Ribalta, J; Castro, A (2012). Complement system and small HDL particles are associated with subclinical atherosclerosis in SLE patients. Atherosclerosis, 225(1), 224-230. DOI: 10.1016/j.atherosclerosis.2012.08.029
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Article's DOI: 10.1016/j.atherosclerosis.2012.08.029
Entity: Universitat Rovira i Virgili
Journal publication year: 2012
Publication Type: Journal Publications