Autor segons l'article: Ginés I, Gil-Cardoso K, Serrano J, Casanova-Marti À, Lobato M, Terra X, Blay MT, Ardévol A, Pinent M
Departament: Bioquímica i Biotecnologia
e-ISSN: 2073-4425
Autor/s de la URV: Ardévol Grau, Anna / Blay Olivé, Maria Teresa / CASANOVA MARTÍ, ANGELA / GINÉS MIR, IRIS / Pinent Armengol, Montserrat / Terra Barbadora, Ximena
Paraules clau: Rat Proanthocyanidin Lpl Long-lasting effect Adiposity proanthocyanidin lpl long-lasting effect keywords adiposity
Resum: A dose of proanthocyanidins with satiating properties proved to be able to limit body weight increase several weeks after administration under exposure to a cafeteria diet. Here we describe some of the molecular targets and the duration of the effects. We treated rats with 500 mg grape seed proanthocyanidin extract (GSPE)/kg BW for ten days. Seven or seventeen weeks after the last GSPE dose, while animals were on a cafeteria diet, we used reverse transcriptase-polymerase chain reaction (RT-PCR) to measure the mRNA of the key energy metabolism enzymes from the liver, adipose depots and muscle. We found that a reduction in the expression of adipose Lpl might explain the lower amount of adipose tissue in rats seven weeks after the last GSPE dose. The liver showed increased expression of Cpt1a and Hmgs2 together with a reduction in Fasn and Dgat2. In addition, muscle showed a higher fatty oxidation (Oxct1 and Cpt1b mRNA). However, after seventeen weeks, there was a completely different gene expression pattern. At the conclusion of the study, seven weeks after the last GSPE administration there was a limitation in adipose accrual that might be mediated by an inhibition of the gene expression of the adipose tissue Lpl. Concomitantly there was an increase in fatty acid oxidation in liver and muscle.
Àrees temàtiques: Medicina ii Medicina i Matemática / probabilidade e estatística Genetics (clinical) Genetics & heredity Genetics Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciência da computação Biotecnología Biodiversidade
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 20734425
Adreça de correu electrònic de l'autor: montserrat.pinent@urv.cat mteresa.blay@urv.cat ximena.terra@urv.cat anna.ardevol@urv.cat
Identificador de l'autor: 0000-0003-3550-5378 0000-0002-6256-9847 0000-0003-1043-5844 0000-0003-0156-7538
Data d'alta del registre: 2024-06-22
Volum de revista: 10
Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
Enllaç font original: https://www.mdpi.com/2073-4425/10/8/598
URL Document de llicència: http://repositori.urv.cat/ca/proteccio-de-dades/
Referència a l'article segons font original: Genes. 10 (8):
Referència de l'ítem segons les normes APA: Ginés I, Gil-Cardoso K, Serrano J, Casanova-Marti À, Lobato M, Terra X, Blay MT, Ardévol A, Pinent M (2019). Proanthocyanidins Limit Adipose Accrual Induced by a Cafeteria Diet, Several Weeks after the End of the Treatment.. Genes, 10(8), -. DOI: 10.3390/genes10080598
DOI de l'article: 10.3390/genes10080598
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2019
Tipus de publicació: Journal Publications
Repositori URV