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Does the fortified milk with high iron dose improve the neurodevelopment of healthy infants? Randomized controlled trial

  • Dades identificatives

    Identificador: imarina:5824252
    Autors:
    Iglesias Vázquez L, Canals J, Voltas N, Jardí C, Hernández C, Bedmar C, Escribano J, Aranda N, Jiménez R, Barroso JM, Ribot B, Arija V
    Resum:
    Since iron plays an important role in several physiological processes, its deficiency but also overload may harm the development of children. The aim was to assess the effect of iron-fortified milk on the iron biochemical status and the neurodevelopment of children at 12 months of age.Randomized controlled trial conducted in 133 Spanish children, allocated in two groups to receive formula milk fortified with 1.2 or 0.4 mg/100 mL of iron between 6 and 12 months of age. Psychomotor (PDI) and Mental (MDI) Development Index were assessed by the Bayley Scales before and after the intervention. Maternal obstetrical and psychosocial variables were recorded. The biochemical iron status of children was measured and data about breastfeeding, anthropometry and infections during the first year of life were registered.Children fortified with 1.2 mg/100 mL of iron, compared with 0.4 mg/100 mL, showed higher serum ferritin (21.5 vs 19.1 μg/L) and lower percentage of both iron deficiency (1.1 to 5.9% vs 3.8 to 16.7%, respectively, from 6 to 12 months) and iron deficiency anemia (4.3 to 1.1% vs 0 to 4.2%, respectively, from 6 to 12 months) at the end of the intervention. No significant differences were found on neurodevelopment from 6 to 12 months between children who received high dose of Fe compared with those who received low dose.Despite differences on the iron status were observed, there were no effects on neurodevelopment of well-nourished children in a developed country after iron supplementation with doses within dietary recommendations. Follow-up studies are needed to test for long-term neurodevelopmental improvement.Retrospectively registered in ClinicalTrials.gov with the ID: NCT02690675.
  • Altres:

    Autor segons l'article: Iglesias Vázquez L, Canals J, Voltas N, Jardí C, Hernández C, Bedmar C, Escribano J, Aranda N, Jiménez R, Barroso JM, Ribot B, Arija V
    Departament: Medicina i Cirurgia Ciències Mèdiques Bàsiques Psicologia
    Autor/s de la URV: Aranda Pons, Núria / Arija Val, Maria Victoria / Canals Sans, Josefa / Escribano Subías, Joaquín / Hernandez Martinez, Carmen / Iglesias Vazquez, Lucia / RIBOT SERRA, BLANCA / Voltas Moreso, Núria
    Paraules clau: Supplementation Serum ferritin Requirements Prevention Prevalence Neurodevelopment Metaanalysis Lactation Iron supplementation Growth Formula Development Deficiency anemia Children Child health Anthropometry iron supplementation development child health anthropometry
    Resum: Since iron plays an important role in several physiological processes, its deficiency but also overload may harm the development of children. The aim was to assess the effect of iron-fortified milk on the iron biochemical status and the neurodevelopment of children at 12 months of age.Randomized controlled trial conducted in 133 Spanish children, allocated in two groups to receive formula milk fortified with 1.2 or 0.4 mg/100 mL of iron between 6 and 12 months of age. Psychomotor (PDI) and Mental (MDI) Development Index were assessed by the Bayley Scales before and after the intervention. Maternal obstetrical and psychosocial variables were recorded. The biochemical iron status of children was measured and data about breastfeeding, anthropometry and infections during the first year of life were registered.Children fortified with 1.2 mg/100 mL of iron, compared with 0.4 mg/100 mL, showed higher serum ferritin (21.5 vs 19.1 μg/L) and lower percentage of both iron deficiency (1.1 to 5.9% vs 3.8 to 16.7%, respectively, from 6 to 12 months) and iron deficiency anemia (4.3 to 1.1% vs 0 to 4.2%, respectively, from 6 to 12 months) at the end of the intervention. No significant differences were found on neurodevelopment from 6 to 12 months between children who received high dose of Fe compared with those who received low dose.Despite differences on the iron status were observed, there were no effects on neurodevelopment of well-nourished children in a developed country after iron supplementation with doses within dietary recommendations. Follow-up studies are needed to test for long-term neurodevelopmental improvement.Retrospectively registered in ClinicalTrials.gov with the ID: NCT02690675.
    Àrees temàtiques: Saúde coletiva Psicología Planejamento urbano e regional / demografia Pediatrics, perinatology and child health Pediatrics Odontología Nutrição Medicina iii Medicina ii Medicina i Interdisciplinar Farmacia Ensino Engenharias ii Enfermagem Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciência de alimentos Biotecnología
    Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 14712431
    Adreça de correu electrònic de l'autor: nuria.aranda@urv.cat nuria.voltas@urv.cat lucia.iglesias@urv.cat carmen.hernandez@urv.cat josefa.canals@urv.cat joaquin.escribano@urv.cat victoria.arija@urv.cat
    Identificador de l'autor: 0000-0001-9708-747X 0000-0001-8855-0282 0000-0001-7131-4144 0000-0001-6328-8679 0000-0002-6209-9558 0000-0002-5041-459X 0000-0002-1758-0975
    Data d'alta del registre: 2024-07-27
    Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
    Enllaç font original: https://bmcpediatr.biomedcentral.com/articles/10.1186/s12887-019-1679-0#Abs1
    URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referència a l'article segons font original: Bmc Pediatrics. 19 (1): 315-315
    Referència de l'ítem segons les normes APA: Iglesias Vázquez L, Canals J, Voltas N, Jardí C, Hernández C, Bedmar C, Escribano J, Aranda N, Jiménez R, Barroso JM, Ribot B, Arija V (2019). Does the fortified milk with high iron dose improve the neurodevelopment of healthy infants? Randomized controlled trial. Bmc Pediatrics, 19(1), 315-315. DOI: https://doi.org/10.1186/s12887-019-1679-0
    DOI de l'article: https://doi.org/10.1186/s12887-019-1679-0
    Entitat: Universitat Rovira i Virgili
    Any de publicació de la revista: 2019
    Tipus de publicació: Journal Publications
  • Paraules clau:

    Pediatrics,Pediatrics, Perinatology and Child Health
    Supplementation
    Serum ferritin
    Requirements
    Prevention
    Prevalence
    Neurodevelopment
    Metaanalysis
    Lactation
    Iron supplementation
    Growth
    Formula
    Development
    Deficiency anemia
    Children
    Child health
    Anthropometry
    iron supplementation
    development
    child health
    anthropometry
    Saúde coletiva
    Psicología
    Planejamento urbano e regional / demografia
    Pediatrics, perinatology and child health
    Pediatrics
    Odontología
    Nutrição
    Medicina iii
    Medicina ii
    Medicina i
    Interdisciplinar
    Farmacia
    Ensino
    Engenharias ii
    Enfermagem
    Educação física
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Ciência de alimentos
    Biotecnología
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