Autor segons l'article: Roigé-Castellví J, Murphy M, Fernández-Ballart J, Canals J
Departament: Ciències Mèdiques Bàsiques
Autor/s de la URV: Canals Sans, Josefa / Fernández Ballart, Joan Domènech / Murphy, Michelle / Roigé Castellví, Joana
Paraules clau: Association Autism spectrum disorders Behavioral-problems Behaviour problems Children Dementia Early-pregnancy Folic-acid supplementation Homocysteine Maternal folate status One-carbon metabolism Polymorphisms Preconception
Resum: We investigated the effect of maternal preconception fasting plasma total homocysteine (tHcy) on psychological problems in children aged 6 years from normal pregnancies.A longitudinal study was carried out from preconception, throughout each trimester of pregnancy, until 6 years of age in the offspring. Fasting blood samples at 2-10 weeks preconception and non-fasting samples at birth were collected. Parents completed the Child Behaviour Checklist (CBCL) and teachers the Inattention-Overactivity with Aggression (IOWA) scale for the 6-year-old children.Elevated tHcy during pregnancy has been associated with several adverse outcomes and with neurodevelopmental impairment in the offspring.ParticipantsThe initial sample consisted of 139 healthy non-pregnant women who were planning on becoming pregnant. Eighty-one mother-child dyads were followed from preconception until 6 years of age.After adjusting for covariables, multiple linear regression models showed that higher preconception tHcy was associated with higher scores in internalizing dimension (β=0·289; P=0.028), specifically in withdrawn behaviour (β=0·349; P=0·009), anxiety/depression (β=0·303; P=0·019) and social problems (β=0·372; P=0·009). Aggressive behaviour in the school setting was higher in children whose mothers had higher preconception tHcy (β=0·351; P=0·014).Moderately elevated preconception tHcy may increase the risk of psychological problems in offspring during childhood. These findings add to the evidence that maternal nutritional status, even before being pregnant, can affect later offspring health and may be important to consider when developing future public health policy.
Àrees temàtiques: Antropologia / arqueologia Biodiversidade Biotecnología Ciência de alimentos Ciências biológicas i Ciências biológicas ii Ciências biológicas iii Economia Educação física Enfermagem Engenharias iii Engenharias iv Farmacia General medicine Interdisciplinar Matemática / probabilidade e estatística Medicina i Medicina ii Medicina iii Medicina veterinaria Medicine (miscellaneous) Nutrição Nutrition & dietetics Nutrition and dietetics Odontología Planejamento urbano e regional / demografia Public health, environmental and occupational health Public, environmental & occupational health Saúde coletiva Serviço social Sociologia i política
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
Adreça de correu electrònic de l'autor: michelle.murphy@urv.cat josefa.canals@urv.cat joana.roige@urv.cat
ISSN: 13689800
Identificador de l'autor: 0000-0002-6304-6204 0000-0002-6209-9558 0000-0002-9138-2360
Data d'alta del registre: 2023-02-22
Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
Referència a l'article segons font original: Public Health Nutrition. 22 (9): 1615-1623
Referència de l'ítem segons les normes APA: Roigé-Castellví J, Murphy M, Fernández-Ballart J, Canals J (2019). Moderately elevated preconception fasting plasma total homocysteine is a risk factor for psychological problems in childhood. Public Health Nutrition, 22(9), 1615-1623. DOI: 10.1017/S1368980018003610
URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2019
Tipus de publicació: Journal Publications
Repositori URV