Autor segons l'article: Rull, Anna; Camps, Jordi; Alonso-Villaverde, Carlos; Joven, Jorge;
Departament: Medicina i Cirurgia
Autor/s de la URV: Camps Andreu, Jorge / Joven Maried, Jorge / RULL AIXA, ANNA
Paraules clau: Transcription factor T-cells Reduces atherosclerosis Macrophage infiltration Low-density-lipoprotein Human endothelial-cells Hepatic steatosis Gene-expression Endoplasmic-reticulum stress Adipose-tissue inflammation
Resum: To maintain homeostasis under diverse metabolic conditions, it is necessary to coordinate nutrient-sensing pathways with the immune response. This coordination requires a complex relationship between cells, hormones, and cytokines in which inflammatory and metabolic pathways are convergent at multiple levels. Recruitment of macrophages to metabolically compromised tissue is a primary event in which chemokines play a crucial role. However, chemokines may also transmit cell signals that generate multiple responses, most unrelated to chemotaxis, that are involved in different biological processes. We have reviewed the evidence showing that monocyte chemoattractant protein-1 (MCP-1 or CCL2) may have a systemic role in the regulation of metabolism that sometimes is not necessarily linked to the traffic of inflammatory cells to susceptible tissues. Main topics cover the relationship betweenMCP-1/CCL2, insulin resistance, inflammation, obesity, and related metabolic disturbances.
Àrees temàtiques: Saúde coletiva Química Psicología Odontología Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Immunology Farmacia Engenharias iv Engenharias iii Enfermagem Educação física Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Cell biology Biotecnología Biodiversidade Biochemistry & molecular biology Antropologia / arqueologia
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 0962-9351
Adreça de correu electrònic de l'autor: jorge.camps@urv.cat jorge.joven@urv.cat
Identificador de l'autor: 0000-0002-3165-3640 0000-0003-2749-4541
Data d'alta del registre: 2023-05-20
Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
Enllaç font original: https://www.hindawi.com/journals/mi/2010/326580/
Referència a l'article segons font original: Mediators Of Inflammation. 2010 (326580): 1244-1253
Referència de l'ítem segons les normes APA: Rull, Anna; Camps, Jordi; Alonso-Villaverde, Carlos; Joven, Jorge; (2010). Insulin Resistance, Inflammation, and Obesity: Role of Monocyte Chemoattractant Protein-1 (or CCL2) in the Regulation of Metabolism. Mediators Of Inflammation, 2010(326580), 1244-1253. DOI: 10.1155/2010/326580
URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
DOI de l'article: 10.1155/2010/326580
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2010
Tipus de publicació: Journal Publications
Repositori URV