Articles producció científica> Medicina i Cirurgia

Insulin Resistance, Inflammation, and Obesity: Role of Monocyte Chemoattractant Protein-1 (or CCL2) in the Regulation of Metabolism

  • Datos identificativos

    Identificador: imarina:5920971
    Autores:
    Rull, AnnaCamps, JordiAlonso-Villaverde, CarlosJoven, Jorge
    Resumen:
    To maintain homeostasis under diverse metabolic conditions, it is necessary to coordinate nutrient-sensing pathways with the immune response. This coordination requires a complex relationship between cells, hormones, and cytokines in which inflammatory and metabolic pathways are convergent at multiple levels. Recruitment of macrophages to metabolically compromised tissue is a primary event in which chemokines play a crucial role. However, chemokines may also transmit cell signals that generate multiple responses, most unrelated to chemotaxis, that are involved in different biological processes. We have reviewed the evidence showing that monocyte chemoattractant protein-1 (MCP-1 or CCL2) may have a systemic role in the regulation of metabolism that sometimes is not necessarily linked to the traffic of inflammatory cells to susceptible tissues. Main topics cover the relationship betweenMCP-1/CCL2, insulin resistance, inflammation, obesity, and related metabolic disturbances.
  • Otros:

    Autor según el artículo: Rull, Anna; Camps, Jordi; Alonso-Villaverde, Carlos; Joven, Jorge;
    Departamento: Medicina i Cirurgia
    Autor/es de la URV: Camps Andreu, Jorge / Joven Maried, Jorge / RULL AIXA, ANNA
    Palabras clave: Transcription factor T-cells Reduces atherosclerosis Macrophage infiltration Low-density-lipoprotein Human endothelial-cells Hepatic steatosis Gene-expression Endoplasmic-reticulum stress Adipose-tissue inflammation
    Resumen: To maintain homeostasis under diverse metabolic conditions, it is necessary to coordinate nutrient-sensing pathways with the immune response. This coordination requires a complex relationship between cells, hormones, and cytokines in which inflammatory and metabolic pathways are convergent at multiple levels. Recruitment of macrophages to metabolically compromised tissue is a primary event in which chemokines play a crucial role. However, chemokines may also transmit cell signals that generate multiple responses, most unrelated to chemotaxis, that are involved in different biological processes. We have reviewed the evidence showing that monocyte chemoattractant protein-1 (MCP-1 or CCL2) may have a systemic role in the regulation of metabolism that sometimes is not necessarily linked to the traffic of inflammatory cells to susceptible tissues. Main topics cover the relationship betweenMCP-1/CCL2, insulin resistance, inflammation, obesity, and related metabolic disturbances.
    Áreas temáticas: Saúde coletiva Química Psicología Odontología Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Immunology Farmacia Engenharias iv Engenharias iii Enfermagem Educação física Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Cell biology Biotecnología Biodiversidade Biochemistry & molecular biology Antropologia / arqueologia
    Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 0962-9351
    Direcció de correo del autor: jorge.camps@urv.cat jorge.joven@urv.cat
    Identificador del autor: 0000-0002-3165-3640 0000-0003-2749-4541
    Fecha de alta del registro: 2023-05-20
    Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
    Enlace a la fuente original: https://www.hindawi.com/journals/mi/2010/326580/
    Referencia al articulo segun fuente origial: Mediators Of Inflammation. 2010 (326580): 1244-1253
    Referencia de l'ítem segons les normes APA: Rull, Anna; Camps, Jordi; Alonso-Villaverde, Carlos; Joven, Jorge; (2010). Insulin Resistance, Inflammation, and Obesity: Role of Monocyte Chemoattractant Protein-1 (or CCL2) in the Regulation of Metabolism. Mediators Of Inflammation, 2010(326580), 1244-1253. DOI: 10.1155/2010/326580
    URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
    DOI del artículo: 10.1155/2010/326580
    Entidad: Universitat Rovira i Virgili
    Año de publicación de la revista: 2010
    Tipo de publicación: Journal Publications
  • Palabras clave:

    Biochemistry & Molecular Biology,Cell Biology,Immunology
    Transcription factor
    T-cells
    Reduces atherosclerosis
    Macrophage infiltration
    Low-density-lipoprotein
    Human endothelial-cells
    Hepatic steatosis
    Gene-expression
    Endoplasmic-reticulum stress
    Adipose-tissue inflammation
    Saúde coletiva
    Química
    Psicología
    Odontología
    Nutrição
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Materiais
    Interdisciplinar
    Immunology
    Farmacia
    Engenharias iv
    Engenharias iii
    Enfermagem
    Educação física
    Economia
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Ciências agrárias i
    Cell biology
    Biotecnología
    Biodiversidade
    Biochemistry & molecular biology
    Antropologia / arqueologia
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