Articles producció científica> Medicina i Cirurgia

Gut metagenomic and short chain fatty acids signature in hypertension: a cross-sectional study

  • Dades identificatives

    Identificador: imarina:6248062
    Autors:
    Calderón-Pérez LGosalbes MJYuste SValls RMPedret ALlauradó EJimenez-Hernandez NArtacho APla-Pagà LCompanys JLudwig IRomero MPRubió LSolà R
    Resum:
    Hypertension is an independent and preventable risk factor for the development of cardiovascular diseases, however, little is known about the impact of gut microbiota composition in its development. We carried out comprehensive gut microbiota analysis and targeted metabolomics in a cross-sectional study of 29 non-treated hypertensive (HT) and 32 normotensive (NT) subjects. We determined fecal microbiota composition by 16S rRNA gene sequencing and bacterial functions by metagenomic analysis. The microbial metabolites analysed were short chain fatty acids (SCFA) both in plasma and feces, and trimethylamine N-oxide (TMAO) in plasma. The overall bacterial composition and diversity of bacterial community in the two groups were not significantly different. However, Ruminococcaceae NK4A214, Ruminococcaceae_UCG-010, Christensenellaceae_R-7, Faecalibacterium prausnitzii and Roseburia hominis were found to be significantly enriched in NT group, whereas, Bacteroides coprocola, Bacteroides plebeius and genera of Lachnospiraceae were increased in HT patients. We found a positive correlation between the HT-associated species and systolic and diastolic blood pressure after adjusted for measured confounders. SCFA showed antagonistic results in plasma and feces, detecting in HT subjects significant higher levels in feces and lower levels in plasma, which could indicate a less efficient SCFA absorption. Overall, our results present a disease classifier based on microbiota and bacterial metabolites to discriminate HT individuals from NT controls in a first disease grade prior to drug treatment.
  • Altres:

    Autor segons l'article: Calderón-Pérez L; Gosalbes MJ; Yuste S; Valls RM; Pedret A; Llauradó E; Jimenez-Hernandez N; Artacho A; Pla-Pagà L; Companys J; Ludwig I; Romero MP; Rubió L; Solà R
    Departament: Medicina i Cirurgia
    Autor/s de la URV: Calderon Pérez, Lorena / Companys Alemany, Judit / Llauradó Ribé, Elisabet / Pedret Figuerola, Anna / PLA PAGA, LAURA / Solà Alberich, Rosa Maria / Valls Zamora, Rosa Maria
    Paraules clau: Sp nov. Middle Microbiota Metabolite Fiber Fermentation Diet Choline Blood-pressure Acetate
    Resum: Hypertension is an independent and preventable risk factor for the development of cardiovascular diseases, however, little is known about the impact of gut microbiota composition in its development. We carried out comprehensive gut microbiota analysis and targeted metabolomics in a cross-sectional study of 29 non-treated hypertensive (HT) and 32 normotensive (NT) subjects. We determined fecal microbiota composition by 16S rRNA gene sequencing and bacterial functions by metagenomic analysis. The microbial metabolites analysed were short chain fatty acids (SCFA) both in plasma and feces, and trimethylamine N-oxide (TMAO) in plasma. The overall bacterial composition and diversity of bacterial community in the two groups were not significantly different. However, Ruminococcaceae NK4A214, Ruminococcaceae_UCG-010, Christensenellaceae_R-7, Faecalibacterium prausnitzii and Roseburia hominis were found to be significantly enriched in NT group, whereas, Bacteroides coprocola, Bacteroides plebeius and genera of Lachnospiraceae were increased in HT patients. We found a positive correlation between the HT-associated species and systolic and diastolic blood pressure after adjusted for measured confounders. SCFA showed antagonistic results in plasma and feces, detecting in HT subjects significant higher levels in feces and lower levels in plasma, which could indicate a less efficient SCFA absorption. Overall, our results present a disease classifier based on microbiota and bacterial metabolites to discriminate HT individuals from NT controls in a first disease grade prior to drug treatment.
    Àrees temàtiques: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Odontología Nutrição Multidisciplinary sciences Multidisciplinary Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Matemática / probabilidade e estatística Letras / linguística Interdisciplinar Geografía Geociências Farmacia Engenharias iv Engenharias iii Engenharias ii Enfermagem Educação física Educação Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Ciência da computação Biotecnología Biodiversidade Astronomia / física
    Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 20452322
    Adreça de correu electrònic de l'autor: judit.companys@urv.cat lorena.calderon@urv.cat elisabet.llaurado@urv.cat anna.pedret@urv.cat rosa.sola@urv.cat rosamaria.valls@urv.cat lorena.calderon@urv.cat judit.companys@urv.cat judit.companys@urv.cat
    Identificador de l'autor: 0000-0003-1485-0818 0000-0003-0766-0733 0000-0002-7439-9531 0000-0002-5327-932X 0000-0002-8359-235X 0000-0002-3351-0942 0000-0003-0766-0733 0000-0003-1485-0818 0000-0003-1485-0818
    Data d'alta del registre: 2023-02-26
    Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
    Enllaç font original: https://www.nature.com/articles/s41598-020-63475-w
    Referència a l'article segons font original: Scientific Reports. 10 (1): 6436-
    Referència de l'ítem segons les normes APA: Calderón-Pérez L; Gosalbes MJ; Yuste S; Valls RM; Pedret A; Llauradó E; Jimenez-Hernandez N; Artacho A; Pla-Pagà L; Companys J; Ludwig I; Romero MP; R (2020). Gut metagenomic and short chain fatty acids signature in hypertension: a cross-sectional study. Scientific Reports, 10(1), 6436-. DOI: 10.1038/s41598-020-63475-w
    URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
    DOI de l'article: 10.1038/s41598-020-63475-w
    Entitat: Universitat Rovira i Virgili
    Any de publicació de la revista: 2020
    Tipus de publicació: Journal Publications
  • Paraules clau:

    Multidisciplinary,Multidisciplinary Sciences
    Sp nov.
    Middle
    Microbiota
    Metabolite
    Fiber
    Fermentation
    Diet
    Choline
    Blood-pressure
    Acetate
    Zootecnia / recursos pesqueiros
    Saúde coletiva
    Química
    Psicología
    Odontología
    Nutrição
    Multidisciplinary sciences
    Multidisciplinary
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Materiais
    Matemática / probabilidade e estatística
    Letras / linguística
    Interdisciplinar
    Geografía
    Geociências
    Farmacia
    Engenharias iv
    Engenharias iii
    Engenharias ii
    Enfermagem
    Educação física
    Educação
    Economia
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Ciências agrárias i
    Ciência de alimentos
    Ciência da computação
    Biotecnología
    Biodiversidade
    Astronomia / física
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