Autor según el artículo: Calderón-Pérez L; Gosalbes MJ; Yuste S; Valls RM; Pedret A; Llauradó E; Jimenez-Hernandez N; Artacho A; Pla-Pagà L; Companys J; Ludwig I; Romero MP; Rubió L; Solà R
Departamento: Medicina i Cirurgia
Autor/es de la URV: Calderon Pérez, Lorena / Companys Alemany, Judit / Llauradó Ribé, Elisabet / Pedret Figuerola, Anna / PLA PAGA, LAURA / Solà Alberich, Rosa Maria / Valls Zamora, Rosa Maria
Palabras clave: Sp nov. Middle Microbiota Metabolite Fiber Fermentation Diet Choline Blood-pressure Acetate
Resumen: Hypertension is an independent and preventable risk factor for the development of cardiovascular diseases, however, little is known about the impact of gut microbiota composition in its development. We carried out comprehensive gut microbiota analysis and targeted metabolomics in a cross-sectional study of 29 non-treated hypertensive (HT) and 32 normotensive (NT) subjects. We determined fecal microbiota composition by 16S rRNA gene sequencing and bacterial functions by metagenomic analysis. The microbial metabolites analysed were short chain fatty acids (SCFA) both in plasma and feces, and trimethylamine N-oxide (TMAO) in plasma. The overall bacterial composition and diversity of bacterial community in the two groups were not significantly different. However, Ruminococcaceae NK4A214, Ruminococcaceae_UCG-010, Christensenellaceae_R-7, Faecalibacterium prausnitzii and Roseburia hominis were found to be significantly enriched in NT group, whereas, Bacteroides coprocola, Bacteroides plebeius and genera of Lachnospiraceae were increased in HT patients. We found a positive correlation between the HT-associated species and systolic and diastolic blood pressure after adjusted for measured confounders. SCFA showed antagonistic results in plasma and feces, detecting in HT subjects significant higher levels in feces and lower levels in plasma, which could indicate a less efficient SCFA absorption. Overall, our results present a disease classifier based on microbiota and bacterial metabolites to discriminate HT individuals from NT controls in a first disease grade prior to drug treatment.
Áreas temáticas: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Odontología Nutrição Multidisciplinary sciences Multidisciplinary Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Matemática / probabilidade e estatística Letras / linguística Interdisciplinar Geografía Geociências Farmacia Engenharias iv Engenharias iii Engenharias ii Enfermagem Educação física Educação Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Ciência da computação Biotecnología Biodiversidade Astronomia / física
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 20452322
Direcció de correo del autor: judit.companys@urv.cat lorena.calderon@urv.cat elisabet.llaurado@urv.cat anna.pedret@urv.cat rosa.sola@urv.cat rosamaria.valls@urv.cat lorena.calderon@urv.cat judit.companys@urv.cat judit.companys@urv.cat
Identificador del autor: 0000-0003-1485-0818 0000-0003-0766-0733 0000-0002-7439-9531 0000-0002-5327-932X 0000-0002-8359-235X 0000-0002-3351-0942 0000-0003-0766-0733 0000-0003-1485-0818 0000-0003-1485-0818
Fecha de alta del registro: 2023-02-26
Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
Enlace a la fuente original: https://www.nature.com/articles/s41598-020-63475-w
Referencia al articulo segun fuente origial: Scientific Reports. 10 (1): 6436-
Referencia de l'ítem segons les normes APA: Calderón-Pérez L; Gosalbes MJ; Yuste S; Valls RM; Pedret A; Llauradó E; Jimenez-Hernandez N; Artacho A; Pla-Pagà L; Companys J; Ludwig I; Romero MP; R (2020). Gut metagenomic and short chain fatty acids signature in hypertension: a cross-sectional study. Scientific Reports, 10(1), 6436-. DOI: 10.1038/s41598-020-63475-w
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
DOI del artículo: 10.1038/s41598-020-63475-w
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2020
Tipo de publicación: Journal Publications