Articles producció científica> Psicologia

Postnatal exposure to low doses of Chlorpyrifos induces long-term effects on 5C-SRTT learning and performance, cholinergic and GABAergic systems and BDNF expression

  • Dades identificatives

    Identificador: imarina:6290527
    Autors:
    Perez-Fernandez C, Morales-Navas M, Guardia-Escote L, Colomina MT, Giménez E, Sánchez-Santed F
    Resum:
    Alterations in attention and inhibitory control are common features in several neurological disorders. Environmental factors such as exposure to pesticides have been linked to their appearance. Chlorpyrifos (CPF) is the most widely used organophosphate compound in the world. CPF exposure during development seems to be critical for later behavioral and molecular disruptions during adult ages, although this depends on the specific period of development, where the preweaning period is the least studied. Despite the abundant empirical work made in the last decades on developmental CPF exposure, the systematic study of this on attention is sparse, and nonexistent concerning inhibitory control, without a single study on preweaning developmental stages. The present research explored the effects of the exposure to low doses of CPF that do not elicit a significant inhibition of the Cholinesterases during this developmental period on rats' behavior in the five-choice serial reaction time task. Behavioral manipulations (inter-trial interval and stimulus duration), pharmacological manipulations (cholinergic and GABAergic drugs) and brain gene expression analyses were also conducted. Exposure to CPF decreased the locomotor activity and enhanced the learning profile of the female rats, increased the impulsive rates, unmasked by a longer inter-trial interval, hypo-sensitized the cholinergic system and down-regulated the mRNA expression levels of the brain-derived neurotrophic factor in the dorsal striatum of the male rats. This happened without significant inhibition of the brain Acetylcholinesterase. All this new information corroborates that the exposure to a common pesticide at low doses during a key, but under-explored developmental period importantly affects different behaviors,
  • Altres:

    Autor segons l'article: Perez-Fernandez C, Morales-Navas M, Guardia-Escote L, Colomina MT, Giménez E, Sánchez-Santed F
    Departament: Psicologia
    Autor/s de la URV: Colomina Fosch, Maria Teresa / Guardia Escoté, Laia
    Paraules clau: Sustained attention Repeated acquisition Reaction-time-task Organophosphate pesticide exposure Neurotrophic factor Neurobehavioral performance Methyl parathion exposure Locomotor activity Learning Insecticide chlorpyrifos Inhibitory control Developmental exposure Chlorpyrifos Brain-derived neurotrophic factor Behavioral consequences Attention learning inhibitory control chlorpyrifos brain-derived neurotrophic factor attention
    Resum: Alterations in attention and inhibitory control are common features in several neurological disorders. Environmental factors such as exposure to pesticides have been linked to their appearance. Chlorpyrifos (CPF) is the most widely used organophosphate compound in the world. CPF exposure during development seems to be critical for later behavioral and molecular disruptions during adult ages, although this depends on the specific period of development, where the preweaning period is the least studied. Despite the abundant empirical work made in the last decades on developmental CPF exposure, the systematic study of this on attention is sparse, and nonexistent concerning inhibitory control, without a single study on preweaning developmental stages. The present research explored the effects of the exposure to low doses of CPF that do not elicit a significant inhibition of the Cholinesterases during this developmental period on rats' behavior in the five-choice serial reaction time task. Behavioral manipulations (inter-trial interval and stimulus duration), pharmacological manipulations (cholinergic and GABAergic drugs) and brain gene expression analyses were also conducted. Exposure to CPF decreased the locomotor activity and enhanced the learning profile of the female rats, increased the impulsive rates, unmasked by a longer inter-trial interval, hypo-sensitized the cholinergic system and down-regulated the mRNA expression levels of the brain-derived neurotrophic factor in the dorsal striatum of the male rats. This happened without significant inhibition of the brain Acetylcholinesterase. All this new information corroborates that the exposure to a common pesticide at low doses during a key, but under-explored developmental period importantly affects different behaviors, neurotransmitter systems, and molecules that are altered in the main neurological disorders observed nowadays.Copyright © 2020. Published by Elsevier Inc.
    Àrees temàtiques: Química Psicología Nutrição Neurosciences Neurology Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar General medicine Farmacia Engenharias iv Enfermagem Educação física Developmental neuroscience Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciência de alimentos
    Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 0014-4886
    Adreça de correu electrònic de l'autor: mariateresa.colomina@urv.cat
    Identificador de l'autor: 0000-0002-5619-4874
    Data d'alta del registre: 2024-06-15
    Volum de revista: 330
    Versió de l'article dipositat: info:eu-repo/semantics/acceptedVersion
    Referència a l'article segons font original: Experimental Neurology. 330 (113356): 113356-113356
    Referència de l'ítem segons les normes APA: Perez-Fernandez C, Morales-Navas M, Guardia-Escote L, Colomina MT, Giménez E, Sánchez-Santed F (2020). Postnatal exposure to low doses of Chlorpyrifos induces long-term effects on 5C-SRTT learning and performance, cholinergic and GABAergic systems and BDNF expression. Experimental Neurology, 330(113356), 113356-113356. DOI: 10.1016/j.expneurol.2020.113356
    URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
    Entitat: Universitat Rovira i Virgili
    Any de publicació de la revista: 2020
    Tipus de publicació: Journal Publications
  • Paraules clau:

    Developmental Neuroscience,Neurology,Neurosciences
    Sustained attention
    Repeated acquisition
    Reaction-time-task
    Organophosphate pesticide exposure
    Neurotrophic factor
    Neurobehavioral performance
    Methyl parathion exposure
    Locomotor activity
    Learning
    Insecticide chlorpyrifos
    Inhibitory control
    Developmental exposure
    Chlorpyrifos
    Brain-derived neurotrophic factor
    Behavioral consequences
    Attention
    learning
    inhibitory control
    chlorpyrifos
    brain-derived neurotrophic factor
    attention
    Química
    Psicología
    Nutrição
    Neurosciences
    Neurology
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Interdisciplinar
    General medicine
    Farmacia
    Engenharias iv
    Enfermagem
    Educação física
    Developmental neuroscience
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciência de alimentos
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