Autor segons l'article: Montagut, Gemma; Baiges, Isabel; Valls, Josep; Terra, Ximena; del Bas, Josep M; Vitrac, Xavier; Richard, Tristan; Merillon, Jean-Michel; Arola, Lluis; Blay, Mayte; Blade, Cinta; Fernandez-Larrea, Juan; Pujadas, Gerard; Salvado, Josepa; Ardevol, Anna
Departament: Bioquímica i Biotecnologia
Autor/s de la URV: Ardévol Grau, Anna / Arola Ferrer, Luis Maria / BAIGES BLANCO, ISABEL MARIA / BLADÉ SEGARRA, MARIA CINTA / Blay Olivé, Maria Teresa / Del Bas Prior, José María / Fernández Larrea, Juan Bautista / MONTAGUT PINO, GEMMA / Pujadas Anguiano, Gerard / Salvadó Rovira, Maria Josepa / Terra Barbadora, Ximena
Paraules clau: Trimer; Triacylglycerol secretion; Procyanidin; Glucose uptake; Dimer-gallate; Cholesterol secretion; Anti-inflammatory effect
Resum: The relationship between grape seed-derived procyanidin extract components and their bioactivity was explored. The monomeric and dimeric structures only acted as anti-inflammatory agents. Similarly, pure C1 trimer was highly effective on LPS-activated macrophages. To reproduce all of the bioactivities of the total extract, a fraction enriched with trimeric structures was needed. This trimeric-enriched fraction was divided into subfractions, the most bioactive of which contained two compounds with a molecular weight equal to a trimer (865) and a dimer-gallate (729), according to spectrometric analysis. Thus, it may be concluded that a mixture of both molecules reproduces the bioactivity in glucose metabolism (3T3-L1), lipid metabolism (HepG2) and macrophage functionality (RAW 264.6). © 2009 Elsevier Ltd. All rights reserved.
Àrees temàtiques: Zootecnia / recursos pesqueiros; Saúde coletiva; Química; Odontología; Nutrition & dietetics; Nutrição; Medicine (miscellaneous); Medicina veterinaria; Medicina ii; Medicina i; Materiais; Matemática / probabilidade e estatística; Interdisciplinar; Geociências; Food science & technology; Food science; Farmacia; Ensino; Engenharias iv; Engenharias iii; Engenharias ii; Engenharias i; Enfermagem; Educação física; Ciências biológicas iii; Ciências biológicas ii; Ciências biológicas i; Ciências ambientais; Ciências agrárias i; Ciência de alimentos; Ciência da computação; Chemistry, applied; Biotecnología; Biodiversidade; Astronomia / física; Analytical chemistry; Administração pública e de empresas, ciências contábeis e turismo
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 03088146
Adreça de correu electrònic de l'autor: anna.ardevol@urv.cat; josepm.delbas@urv.cat; ximena.terra@urv.cat; mteresa.blay@urv.cat; gerard.pujadas@urv.cat; juanbautista.fernandez@urv.cat; lluis.arola@urv.cat
Data d'alta del registre: 2025-12-01
Versió de l'article dipositat: info:eu-repo/semantics/acceptedVersion
Enllaç font original: https://www.sciencedirect.com/science/article/abs/pii/S0308814609002325?via%3Dihub
URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
Referència a l'article segons font original: Food Chemistry. 116 (1): 265-270
Referència de l'ítem segons les normes APA: Montagut, Gemma; Baiges, Isabel; Valls, Josep; Terra, Ximena; del Bas, Josep M; Vitrac, Xavier; Richard, Tristan; Merillon, Jean-Michel; Arola, Lluis; (2009). A trimer plus a dimer-gallate reproduce the bioactivity described for an extract of grape seed procyanidins. Food Chemistry, 116(1), 265-270. DOI: 10.1016/j.foodchem.2009.02.044
DOI de l'article: 10.1016/j.foodchem.2009.02.044
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2009-09-01
Tipus de publicació: Journal Publications
Repositori URV