Autor segons l'article: Llauradó G; González-Clemente J; Maymó-Masip E; Subías D; Vendrell J; Chacón M
Departament: Medicina i Cirurgia Bioquímica i Biotecnologia
Autor/s de la URV: Chacón Navarro, María Gema / Maymo Masip, Elsa / Rodríguez Chacón, Matilde / VENDRELL FERRE, JOAN / Vendrell Ortega, Juan José
Paraules clau: Stweak Soluble tweak Prediction Mortality Macrophages Inflammation Identification Disease Complications Arterial stiffness
Resum: Objective: To test the usefulness of serum concentrations of tumor necrosis factor-like weak inducer of apoptosis (sTWEAK) and soluble scavenger receptor CD163 (sCD163) as markers of subtle inflammation in patients with type 1 diabetes mellitus (T1DM) without clinical cardiovascular (CV) disease and to evaluate their relationship with arterial stiffness (AS). Methods: Sixty-eight patients with T1DM and 68 age and sex-matched, healthy subjects were evaluated. Anthropometrical variables and CV risk factors were recorded. Serum concentrations of sTWEAK and sCD163 were measured. AS was assessed by aortic pulse wave velocity (aPWV). All statistical analyses were stratified by gender. Results: T1DM patients showed lower serum concentrations of sTWEAK (Men: 1636.5 (1146.3-3754.8) pg/mL vs. 765.9 (650.4-1097.1) pg/mL; p<0.001. Women: 1401.0 (788.0-2422.2) pg/mL vs. 830.1 (562.6-1175.9) pg/mL; p = 0.011) compared with their respective controls. Additionally, T1DM men had higher serum concentrations of sCD163 (285.0 (247.7-357.1) ng/mL vs. 224.8 (193.3-296.5) ng/mL; p = 0.012) compared with their respective controls. sTWEAK correlated negatively with aPWV in men (r = -0.443; p<0.001). However, this association disappeared after adjusting for potential confounders. In men, the best multiple linear regression model showed that the independent predictors of sTWEAK were T1DM and WHR (R2 = 0.640; p<0.001). In women, T1DM and SBP were the independent predictors for sTWEAK (R2 = 0.231; p = 0.001). Conclusion: sTWEAK is decreased in T1DM patients compared with age and sex-matched healthy subjects after adjusting for classic CV risk factors, although sTWEAK levels may be partially influenced by some of them. Additionally, T1DM men have higher serum concentrations of sCD163. These results point out an association between the inflammatory system and CV risk in T1DM. © 2012 Llauradó et al.
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Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 19326203
Adreça de correu electrònic de l'autor: mariagema.chacon@urv.cat elsa.maymo@urv.cat matilde.rodriguez@urv.cat juanjose.vendrell@urv.cat
Identificador de l'autor: 0000-0002-9133-3120 0000-0002-6994-6115
Data d'alta del registre: 2024-06-15
Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
Enllaç font original: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0043919
Referència a l'article segons font original: Plos One. 7 (8): e43919-
Referència de l'ítem segons les normes APA: Llauradó G; González-Clemente J; Maymó-Masip E; Subías D; Vendrell J; Chacón M (2012). Serum levels of TWEAK and scavenger receptor CD163 in type 1 diabetes mellitus: Relationship with cardiovascular risk factors. A case-control study. Plos One, 7(8), e43919-. DOI: 10.1371/journal.pone.0043919
URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
DOI de l'article: 10.1371/journal.pone.0043919
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2012
Tipus de publicació: Journal Publications
Repositori URV