Serum levels of TWEAK and scavenger receptor CD163 in type 1 diabetes mellitus: Relationship with cardiovascular risk factors. A case-control study

Autor según el artículo: Llaurado, Gemma; Gonzalez-Clemente, Jose-Miguel; Maymo-Masip, Elsa; Subias, David; Vendrell, Joan; Chacon, Matilde R

Departamento: Medicina i Cirurgia; Bioquímica i Biotecnologia

Autor/es de la URV: Chacón Navarro, María Gema / Maymo Masip, Elsa / Rodríguez Chacón, Matilde / VENDRELL FERRE, JOAN / Vendrell Ortega, Juan José

Palabras clave: Vascular stiffness; Tumor necrosis factors; Tnfsf12 protein, human; Stweak; Soluble tweak; Risk factors; Receptors, cell surface; Pulse wave analysis; Prediction; Mortality; Middle aged; Male; Macrophages; Inflammation; Identification; Humans; Female; Disease; Diabetes mellitus, type 1; Cytokine tweak; Complications; Cd163 antigen; Case-control studies; Biomarkers; Arterial stiffness; Aorta; Antigens, differentiation, myelomonocytic; Antigens, cd; Aged; Adult; Adolescent

Resumen: Objective: To test the usefulness of serum concentrations of tumor necrosis factor-like weak inducer of apoptosis (sTWEAK) and soluble scavenger receptor CD163 (sCD163) as markers of subtle inflammation in patients with type 1 diabetes mellitus (T1DM) without clinical cardiovascular (CV) disease and to evaluate their relationship with arterial stiffness (AS). Methods: Sixty-eight patients with T1DM and 68 age and sex-matched, healthy subjects were evaluated. Anthropometrical variables and CV risk factors were recorded. Serum concentrations of sTWEAK and sCD163 were measured. AS was assessed by aortic pulse wave velocity (aPWV). All statistical analyses were stratified by gender. Results: T1DM patients showed lower serum concentrations of sTWEAK (Men: 1636.5 (1146.3-3754.8) pg/mL vs. 765.9 (650.4-1097.1) pg/mL; p<0.001. Women: 1401.0 (788.0-2422.2) pg/mL vs. 830.1 (562.6-1175.9) pg/mL; p = 0.011) compared with their respective controls. Additionally, T1DM men had higher serum concentrations of sCD163 (285.0 (247.7-357.1) ng/mL vs. 224.8 (193.3-296.5) ng/mL; p = 0.012) compared with their respective controls. sTWEAK correlated negatively with aPWV in men (r = -0.443; p<0.001). However, this association disappeared after adjusting for potential confounders. In men, the best multiple linear regression model showed that the independent predictors of sTWEAK were T1DM and WHR (R2 = 0.640; p<0.001). In women, T1DM and SBP were the independent predictors for sTWEAK (R2 = 0.231; p = 0.001). Conclusion: sTWEAK is decreased in T1DM patients compared with age and sex-matched healthy subjects after adjusting for classic CV risk factors, although sTWEAK levels may be partially influenced by some of them. Additionally, T1DM men have higher serum concentrations of sCD163. These results point out an association between the inflammatory system and CV risk in T1DM. © 2012 Llauradó et al.

Áreas temáticas: Zootecnia / recursos pesqueiros; Sociology; Sociología; Serviço social; Saúde coletiva; Química; Psychology; Psicología; Planejamento urbano e regional / demografia; Odontología; Nutrição; Multidisciplinary sciences; Multidisciplinary; Medicine (miscellaneous); Medicina veterinaria; Medicina iii; Medicina ii; Medicina i; Materiais; Matemática / probabilidade e estatística; Linguística e literatura; Letras / linguística; Interdisciplinary research in the social sciences; Interdisciplinar; Human geography and urban studies; History & philosophy of science; Historia; Geografía; Geociências; General medicine; General biochemistry,genetics and molecular biology; General agricultural and biological sciences; Farmacia; Environmental studies; Ensino; Engenharias iv; Engenharias iii; Engenharias ii; Engenharias i; Enfermagem; Educação física; Educação; Economia; Direito; Demography; Comunicação e informação; Ciências sociais aplicadas i; Ciências biológicas iii; Ciências biológicas ii; Ciências biológicas i; Ciências ambientais; Ciências agrárias i; Ciência política e relações internacionais; Ciência de alimentos; Ciência da computação; Biotecnología; Biology; Biodiversidade; Biochemistry, genetics and molecular biology (miscellaneous); Astronomia / física; Arquitetura, urbanismo e design; Archaeology; Antropologia / arqueologia; Anthropology; Agricultural and biological sciences (miscellaneous); Administração, ciências contábeis e turismo; Administração pública e de empresas, ciências contábeis e turismo

Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 19326203

Direcció de correo del autor: elsa.maymo@urv.cat; matilde.rodriguez@urv.cat; mariagema.chacon@urv.cat; jvortega@iispv.cat

Fecha de alta del registro: 2025-02-08

Versión del articulo depositado: info:eu-repo/semantics/publishedVersion

Enlace a la fuente original: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0043919

URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/

Referencia al articulo segun fuente origial: Plos One. 7 (8): e43919-

Referencia de l'ítem segons les normes APA: Llaurado, Gemma; Gonzalez-Clemente, Jose-Miguel; Maymo-Masip, Elsa; Subias, David; Vendrell, Joan; Chacon, Matilde R (2012). Serum levels of TWEAK and scavenger receptor CD163 in type 1 diabetes mellitus: Relationship with cardiovascular risk factors. A case-control study. Plos One, 7(8), e43919-. DOI: 10.1371/journal.pone.0043919

DOI del artículo: 10.1371/journal.pone.0043919

Entidad: Universitat Rovira i Virgili

Año de publicación de la revista: 2012

Tipo de publicación: Journal Publications