Low-molecular procyanidin rich grape seed extract exerts antihypertensive effect in males spontaneously hypertensive rats

Identificador:  imarina:6387264

Handle:  https://hdl.handle.net/20.500.11797/imarina6387264

Autors:  Quinones, M; Guerrero, L; Suarez, M; Pons, Z; Aleixandre, A; Arola, L; Muguerza, B

Resum:
Grapes are a good source of flavonoids, which have been previously demonstrated to exert beneficial healthy effects on cardiovascular diseases. The aims of this study were to extensively characterise a grape seed procyanidin extract (GSPE) (total phenolic content, antioxidant capacity and HPLC-MS phenolic profile) and, to assess its antihypertensive effect in spontaneously hypertensive rats (SHR) which is a model of genetically hypertensive rat analogue to the essential hypertension in humans. The hypotensive effect of GSPE was also proved in normotensive Wistar-Kyoto rats. Chromatographic analysis of the extract showed that the most abundant polyphenols are monomers and dimers, in their free forms and linked to a gallate. GSPE produced a significant decrease in systolic and diastolic blood pressure of SHR dose-dependently up to 375. mg/kg (maximum decrease 6. h post-administration) and did not affect blood pressure of Wistar-Kyoto rats. GSPE increased the activity of an antioxidant endogen system, but did not affect plasma ACE activity in these animals. © 2013 Elsevier Ltd.