Low folate status enhances pregnancy changes in plasma betaine and dimethylglycine concentrations and the association between betaine and homocysteine

Autor segons l'article: Fernandez-Roig, Silvia; Cavalle-Busquets, Pere; Fernandez-Ballart, Joan D; Ballesteros, Monica; Isabel Berrocal-Zaragoza, Maria; Salat-Batlle, Judith; Ueland, Per M; Murphy, Michelle M

Departament: Medicina i Cirurgia

Autor/s de la URV: Ballesteros Pérez, Monica / BERROCAL ZARAGOZA, MA. ISABEL / Cavallé Busquets, Pere / Fernández Ballart, Joan Domènech / FERNÁNDEZ ROIG, SÍLVIA / Murphy, Michelle / SALAT BATLLE, JUDITH

Paraules clau: Good health and well-being

Resum: Background: Folate, choline, and betaine participate in homocysteine metabolism. It is not known whether they interact during pregnancy. Objective: The objective was to investigate how folate status affects choline, betaine, and dimethylglycine during pregnancy. Design: Fasting plasma folate, cobalamin, free choline, betaine, dimethylglycine, and total homocysteine (tHcy) were measured longitudinally at <12, 15, 24-27, and 34 gestational weeks (GW); at labor (nonfasting); and in the cord in participants (n = 522) from the Reus- Tarragona Birth Cohort (NUTrició i Creixement Intrauterí Retardat phase). Timing, dose, and duration of folic acid supplement use were recorded. Folate status was classified as below (low) or above (high) median plasma folate at baseline (27.6 nmol/L) and at 24-27 GW (11.4 nmol/L). Associations between folate or betaine with tHcy were investigated by using multiple linear regression analysis. Results: Plasma betaine decreased by 34.8% (1.0%) throughout pregnancy, and dimethylglycine increased by 39.7% (2.7%) between 24-27 GW and labor (all P < 0.001). Compared with high folate status, low status was associated with a higher dimethylglycine/betaine ratio from 15 GW and with lower plasma betaine and higher dimethylglycine from 24 to 27 GW, for the rest of pregnancy. Regression analysis showed that by 24-27 GW, both plasma folate and betaine were inversely associated with tHcy when folate status was low and that the association between betaine and tHcy depended on folate status at 24-27 and 34 GW (interaction terms: P < 0.001 and P , 0.01). Betaine was inversely associated with tHcy at labor regardless of folate status. Conclusion: Low folate status enhances the reduction in betaine and the increase in dimethylglycine during pregnancy and strengthens the association between betaine and tHcy. This trial was registered at clinicaltrials.gov as NCT01778205. © 2013 American Society for Nutrition.

Grup de recerca: SIGNAMET

Àrees temàtiques: Biotecnología; Ciência de alimentos; Ciências biológicas ii; Educação física; Enfermagem; General medicine; Medicina i; Medicina ii; Medicina iii; Medicine (miscellaneous); Nutrição; Nutrition & dietetics; Nutrition and dietetics; Odontología; Saúde coletiva; Serviço social

Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/

Adreça de correu electrònic de l'autor: michelle.murphy@urv.cat; monica.ballesteros@urv.cat; pere.cavalleb@urv.cat

ISSN: 00029165

Data d'alta del registre: 2025-02-08

Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion

Referència a l'article segons font original: American Journal Of Clinical Nutrition. 97 (6): 1252-1259

Referència de l'ítem segons les normes APA: Fernandez-Roig, Silvia; Cavalle-Busquets, Pere; Fernandez-Ballart, Joan D; Ballesteros, Monica; Isabel Berrocal-Zaragoza, Maria; Salat-Batlle, Judith; (2013). Low folate status enhances pregnancy changes in plasma betaine and dimethylglycine concentrations and the association between betaine and homocysteine. American Journal Of Clinical Nutrition, 97(6), 1252-1259. DOI: 10.3945/ajcn.112.054189

URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/

DOI de l'article: 10.3945/ajcn.112.054189

Entitat: Universitat Rovira i Virgili

Any de publicació de la revista: 2013

Tipus de publicació: Journal Publications