Autor segons l'article: Santafe, Manel M; Garcia, Neus; Tomas, Marta; Obis, Teresa; Lanuza, Maria A; Besalduch, Nuria; Tomas, Josep
Departament: Ciències Mèdiques Bàsiques
Autor/s de la URV: BESALDUCH CANES, NÚRIA MONTSERRAT / Garcia Sancho, Maria de les Neus / Lanuza Escolano, María Angel / Santafé Martínez, Manuel / Tomás Ferré, José Maria / Tomas Marginet, Marta
Paraules clau: Signal transduction; Receptor, trkb; Protein kinase c; Protein kinase a; Neuromuscular junction; Mice; Male; Excitatory postsynaptic potentials; Cyclic amp-dependent protein kinases; Brain-derived neurotrophic factor; Animals; Acetylcholine; protein kinase a; brain-derived neurotrophic factor
Resum: We conducted an electrophysiological study of the functional link between the tropomyosin-related kinase B (trkB) receptor signaling mechanism and serine-threonine kinases, both protein kinase C (PKC) and protein kinase A (PKA). We describe their coordinated role in transmitter release at the neuromuscular junction (NMJ) of the Levator auris longus muscle of the adult mouse. The trkB receptor normally seems to be coupled to stimulate ACh release because inhibiting the trkB receptor with K-252a results in a significant reduction in the size of EPPs. We found that the intracellular PKC pathway can operate as in basal conditions (to potentiate ACh release) without the involvement of the trkB receptor function, although the trkB pathway needs an operative PKC pathway if it is to couple to the release mechanism and potentiate it. To actively stimulate PKA (which also results in ACh release potentiation), the operativity of trkB is a necessary condition, and one effect of trkB may be PKA stimulation. © 2014 Elsevier Ireland Ltd.
Àrees temàtiques: Zootecnia / recursos pesqueiros; Saúde coletiva; Química; Psicología; Odontología; Nutrição; Neurosciences; Neuroscience (miscellaneous); Neuroscience (all); Medicina veterinaria; Medicina iii; Medicina ii; Medicina i; Matemática / probabilidade e estatística; Letras / linguística; Interdisciplinar; General neuroscience; General medicine; Farmacia; Ensino; Engenharias iv; Enfermagem; Educação física; Ciências biológicas iii; Ciências biológicas ii; Ciências biológicas i; Ciências ambientais; Ciências agrárias i; Ciência de alimentos; Ciência da computação; Biotecnología; Biodiversidade; Astronomia / física; Arquitetura, urbanismo e design
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 03043940
Adreça de correu electrònic de l'autor: marta.tomas@urv.cat; josepmaria.tomas@urv.cat; mariaangel.lanuza@urv.cat; manuel.santafe@urv.cat
Data d'alta del registre: 2025-01-08
Versió de l'article dipositat: info:eu-repo/semantics/submittedVersion
Enllaç font original: https://www.sciencedirect.com/science/article/abs/pii/S030439401400010X?via%3Dihub
URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
Referència a l'article segons font original: Neuroscience Letters. 561 171-175
Referència de l'ítem segons les normes APA: Santafe, Manel M; Garcia, Neus; Tomas, Marta; Obis, Teresa; Lanuza, Maria A; Besalduch, Nuria; Tomas, Josep (2014). The interaction between tropomyosin-related kinase B receptors and serine kinases modulates acetylcholine release in adult neuromuscular junctions. Neuroscience Letters, 561(), 171-175. DOI: 10.1016/j.neulet.2013.12.073
DOI de l'article: 10.1016/j.neulet.2013.12.073
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2014
Tipus de publicació: Journal Publications
Repositori URV