Articles producció científica> Ciències Mèdiques Bàsiques

The interaction between tropomyosin-related kinase B receptors and serine kinases modulates acetylcholine release in adult neuromuscular junctions

  • Identification data

    Identifier: imarina:6387647
    Authors:
    Santafé MGarcia NTomàs MObis TLanuza MBesalduch NTomàs J
    Abstract:
    We conducted an electrophysiological study of the functional link between the tropomyosin-related kinase B (trkB) receptor signaling mechanism and serine-threonine kinases, both protein kinase C (PKC) and protein kinase A (PKA). We describe their coordinated role in transmitter release at the neuromuscular junction (NMJ) of the Levator auris longus muscle of the adult mouse. The trkB receptor normally seems to be coupled to stimulate ACh release because inhibiting the trkB receptor with K-252a results in a significant reduction in the size of EPPs. We found that the intracellular PKC pathway can operate as in basal conditions (to potentiate ACh release) without the involvement of the trkB receptor function, although the trkB pathway needs an operative PKC pathway if it is to couple to the release mechanism and potentiate it. To actively stimulate PKA (which also results in ACh release potentiation), the operativity of trkB is a necessary condition, and one effect of trkB may be PKA stimulation. © 2014 Elsevier Ireland Ltd.
  • Others:

    Author, as appears in the article.: Santafé M; Garcia N; Tomàs M; Obis T; Lanuza M; Besalduch N; Tomàs J
    Department: Ciències Mèdiques Bàsiques
    URV's Author/s: BESALDUCH CANES, NÚRIA MONTSERRAT / Garcia Sancho, Maria de les Neus / Lanuza Escolano, María Angel / Santafé Martínez, Manuel / Tomás Ferré, José Maria / Tomas Marginet, Marta
    Keywords: Protein kinase c Protein kinase a Brain-derived neurotrophic factor protein kinase a brain-derived neurotrophic factor
    Abstract: We conducted an electrophysiological study of the functional link between the tropomyosin-related kinase B (trkB) receptor signaling mechanism and serine-threonine kinases, both protein kinase C (PKC) and protein kinase A (PKA). We describe their coordinated role in transmitter release at the neuromuscular junction (NMJ) of the Levator auris longus muscle of the adult mouse. The trkB receptor normally seems to be coupled to stimulate ACh release because inhibiting the trkB receptor with K-252a results in a significant reduction in the size of EPPs. We found that the intracellular PKC pathway can operate as in basal conditions (to potentiate ACh release) without the involvement of the trkB receptor function, although the trkB pathway needs an operative PKC pathway if it is to couple to the release mechanism and potentiate it. To actively stimulate PKA (which also results in ACh release potentiation), the operativity of trkB is a necessary condition, and one effect of trkB may be PKA stimulation. © 2014 Elsevier Ireland Ltd.
    Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Odontología Nutrição Neurosciences Neuroscience (miscellaneous) Neuroscience (all) Medicina veterinaria Medicina iii Medicina ii Medicina i Matemática / probabilidade e estatística Letras / linguística Interdisciplinar General neuroscience General medicine Farmacia Ensino Engenharias iv Enfermagem Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Ciência da computação Biotecnología Biodiversidade Astronomia / física Arquitetura, urbanismo e design
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 03043940
    Author's mail: marta.tomas@urv.cat josepmaria.tomas@urv.cat mariaangel.lanuza@urv.cat manuel.santafe@urv.cat
    Author identifier: 0000-0002-4151-1697 0000-0002-0406-0006 0000-0003-4795-4103 0000-0002-5462-5108
    Record's date: 2024-09-07
    Papper version: info:eu-repo/semantics/submittedVersion
    Link to the original source: https://www.sciencedirect.com/science/article/abs/pii/S030439401400010X?via%3Dihub
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Neuroscience Letters. 561 171-175
    APA: Santafé M; Garcia N; Tomàs M; Obis T; Lanuza M; Besalduch N; Tomàs J (2014). The interaction between tropomyosin-related kinase B receptors and serine kinases modulates acetylcholine release in adult neuromuscular junctions. Neuroscience Letters, 561(), 171-175. DOI: 10.1016/j.neulet.2013.12.073
    Article's DOI: 10.1016/j.neulet.2013.12.073
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2014
    Publication Type: Journal Publications
  • Keywords:

    Neuroscience (Miscellaneous),Neurosciences
    Protein kinase c
    Protein kinase a
    Brain-derived neurotrophic factor
    protein kinase a
    brain-derived neurotrophic factor
    Zootecnia / recursos pesqueiros
    Saúde coletiva
    Química
    Psicología
    Odontología
    Nutrição
    Neurosciences
    Neuroscience (miscellaneous)
    Neuroscience (all)
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Matemática / probabilidade e estatística
    Letras / linguística
    Interdisciplinar
    General neuroscience
    General medicine
    Farmacia
    Ensino
    Engenharias iv
    Enfermagem
    Educação física
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Ciências agrárias i
    Ciência de alimentos
    Ciência da computação
    Biotecnología
    Biodiversidade
    Astronomia / física
    Arquitetura, urbanismo e design
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