Author, as appears in the article.: Santafé M; Garcia N; Tomàs M; Obis T; Lanuza M; Besalduch N; Tomàs J
Department: Ciències Mèdiques Bàsiques
URV's Author/s: BESALDUCH CANES, NÚRIA MONTSERRAT / Garcia Sancho, Maria de les Neus / Lanuza Escolano, María Angel / Santafé Martínez, Manuel / Tomás Ferré, José Maria / Tomas Marginet, Marta
Keywords: brain-derived neurotrophic factor protein kinase a Brain-derived neurotrophic factor Protein kinase a Protein kinase c
Abstract: We conducted an electrophysiological study of the functional link between the tropomyosin-related kinase B (trkB) receptor signaling mechanism and serine-threonine kinases, both protein kinase C (PKC) and protein kinase A (PKA). We describe their coordinated role in transmitter release at the neuromuscular junction (NMJ) of the Levator auris longus muscle of the adult mouse. The trkB receptor normally seems to be coupled to stimulate ACh release because inhibiting the trkB receptor with K-252a results in a significant reduction in the size of EPPs. We found that the intracellular PKC pathway can operate as in basal conditions (to potentiate ACh release) without the involvement of the trkB receptor function, although the trkB pathway needs an operative PKC pathway if it is to couple to the release mechanism and potentiate it. To actively stimulate PKA (which also results in ACh release potentiation), the operativity of trkB is a necessary condition, and one effect of trkB may be PKA stimulation. © 2014 Elsevier Ireland Ltd.
Thematic Areas: Arquitetura, urbanismo e design Astronomia / física Biodiversidade Biotecnología Ciência da computação Ciência de alimentos Ciências agrárias i Ciências ambientais Ciências biológicas i Ciências biológicas ii Ciências biológicas iii Educação física Enfermagem Engenharias iv Ensino Farmacia General medicine General neuroscience Interdisciplinar Letras / linguística Matemática / probabilidade e estatística Medicina i Medicina ii Medicina iii Medicina veterinaria Neuroscience (all) Neuroscience (miscellaneous) Neurosciences Nutrição Odontología Psicología Química Saúde coletiva Zootecnia / recursos pesqueiros
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: josepmaria.tomas@urv.cat mariaangel.lanuza@urv.cat manuel.santafe@urv.cat marta.tomas@urv.cat
ISSN: 03043940
Author identifier: 0000-0002-0406-0006 0000-0003-4795-4103 0000-0002-5462-5108 0000-0002-4151-1697
Record's date: 2023-02-19
Papper version: info:eu-repo/semantics/submittedVersion
Link to the original source: https://www.sciencedirect.com/science/article/abs/pii/S030439401400010X?via%3Dihub
Papper original source: Neuroscience Letters. 561 171-175
APA: Santafé M; Garcia N; Tomàs M; Obis T; Lanuza M; Besalduch N; Tomàs J (2014). The interaction between tropomyosin-related kinase B receptors and serine kinases modulates acetylcholine release in adult neuromuscular junctions. Neuroscience Letters, 561(), 171-175. DOI: 10.1016/j.neulet.2013.12.073
Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/
Article's DOI: 10.1016/j.neulet.2013.12.073
Entity: Universitat Rovira i Virgili
Journal publication year: 2014
Publication Type: Journal Publications
Repositori URV