Autor segons l'article: Berrocal-Zaragoza MI; Sequeira JM; Murphy MM; Fernandez-Ballart JD; Abdel Baki SG; Bergold PJ; Quadros EV
Departament: Ciències Mèdiques Bàsiques
Autor/s de la URV: BERROCAL ZARAGOZA, MA. ISABEL / Fernández Ballart, Joan Domènech / Murphy, Michelle
Paraules clau: Weaning period Set shifting Folate receptors Brain function Behaviours
Resum: © The Authors 2014. Folate is essential for fetal development, and its deficiency during gestation causes behavioural deficits in the offspring. The present study investigated its influence during weaning on brain function in the pups of rats that were put on a folate-deficient (FD) diet on postnatal day (PND) 1. Systemic folate deficiency in pups on the FD diet (n 15) was evident from the dramatically lower hepatic folate concentrations (median 23.7, range 8.1-48.4 ng/mg protein) and higher homocysteine concentrations (median 27.7, range 14.7-45.5 pmol/mg protein), respectively, compared with those of pups on the normal diet (ND; n 9) (median 114.5, range 64.5-158.5 ng/mg protein and median 15.5, range 11.6-18.9 pmol/mg protein) on PND 23. Brain folate concentrations although low were similar in pups on the FD diet (median 10.5, range 5.5-24.5 ng/mg protein) and ND (median 11.1, range 7.1-24.2 ng/mg protein). There was a high accumulation of homocysteine in the brain of FD pups, mostly in the hippocampus (median 58.1, range 40.8-99.7 pmol/mg protein) and cerebellum (median 69.1, range 50.8-126.6 pmol/mg protein), indicating metabolic folate deficiency despite normal brain folate concentrations. Developmental deficits or autistic traits were more frequent in the FD group than in the ND group and repetitive self-grooming occurred, on average, three times (range 1-8) v. once (range 0-3) during 5 min, respectively. Long-term memory or spatial learning and set-shifting deficits affected 12 to 62 % of rats in the FD group compared with none in the ND group. Post-weaning folic acid supplementation did not correct these deficits. These observations indicate that folate deficiency during weaning affects postnatal development even when gestational folate supply is normal.
Àrees temàtiques: Zootecnia / recursos pesqueiros Saúde coletiva Química Odontología Nutrition and dietetics Nutrition & dietetics Nutrição Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Matemática / probabilidade e estatística Interdisciplinar General medicine Farmacia Engenharias iv Engenharias ii Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Biotecnología Biodiversidade Administração pública e de empresas, ciências contábeis e turismo
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 14752662
Adreça de correu electrònic de l'autor: michelle.murphy@urv.cat
Identificador de l'autor: 0000-0002-6304-6204
Data d'alta del registre: 2024-09-07
Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
Enllaç font original: https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/folate-deficiency-in-rat-pups-during-weaning-causes-learning-and-memory-deficits/391AD532CCB76F5680C6C9C202F9795C#
URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
Referència a l'article segons font original: British Journal Of Nutrition. 112 (8): 1323-1332
Referència de l'ítem segons les normes APA: Berrocal-Zaragoza MI; Sequeira JM; Murphy MM; Fernandez-Ballart JD; Abdel Baki SG; Bergold PJ; Quadros EV (2014). Folate deficiency in rat pups during weaning causes learning and memory deficits. British Journal Of Nutrition, 112(8), 1323-1332. DOI: 10.1017/S0007114514002116
DOI de l'article: 10.1017/S0007114514002116
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2014
Tipus de publicació: Journal Publications