Autor según el artículo: Berrocal-Zaragoza MI; Sequeira JM; Murphy MM; Fernandez-Ballart JD; Abdel Baki SG; Bergold PJ; Quadros EV
Departamento: Ciències Mèdiques Bàsiques
Autor/es de la URV: BERROCAL ZARAGOZA, MA. ISABEL / Fernández Ballart, Joan Domènech / Murphy, Michelle
Palabras clave: Weaning period Set shifting Folate receptors Brain function Behaviours
Resumen: © The Authors 2014. Folate is essential for fetal development, and its deficiency during gestation causes behavioural deficits in the offspring. The present study investigated its influence during weaning on brain function in the pups of rats that were put on a folate-deficient (FD) diet on postnatal day (PND) 1. Systemic folate deficiency in pups on the FD diet (n 15) was evident from the dramatically lower hepatic folate concentrations (median 23.7, range 8.1-48.4 ng/mg protein) and higher homocysteine concentrations (median 27.7, range 14.7-45.5 pmol/mg protein), respectively, compared with those of pups on the normal diet (ND; n 9) (median 114.5, range 64.5-158.5 ng/mg protein and median 15.5, range 11.6-18.9 pmol/mg protein) on PND 23. Brain folate concentrations although low were similar in pups on the FD diet (median 10.5, range 5.5-24.5 ng/mg protein) and ND (median 11.1, range 7.1-24.2 ng/mg protein). There was a high accumulation of homocysteine in the brain of FD pups, mostly in the hippocampus (median 58.1, range 40.8-99.7 pmol/mg protein) and cerebellum (median 69.1, range 50.8-126.6 pmol/mg protein), indicating metabolic folate deficiency despite normal brain folate concentrations. Developmental deficits or autistic traits were more frequent in the FD group than in the ND group and repetitive self-grooming occurred, on average, three times (range 1-8) v. once (range 0-3) during 5 min, respectively. Long-term memory or spatial learning and set-shifting deficits affected 12 to 62 % of rats in the FD group compared with none in the ND group. Post-weaning folic acid supplementation did not correct these deficits. These observations indicate that folate deficiency during weaning affects postnatal development even when gestational folate supply is normal.
Áreas temáticas: Zootecnia / recursos pesqueiros Saúde coletiva Química Odontología Nutrition and dietetics Nutrition & dietetics Nutrição Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Matemática / probabilidade e estatística Interdisciplinar General medicine Farmacia Engenharias iv Engenharias ii Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Biotecnología Biodiversidade Administração pública e de empresas, ciências contábeis e turismo
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 14752662
Direcció de correo del autor: michelle.murphy@urv.cat
Identificador del autor: 0000-0002-6304-6204
Fecha de alta del registro: 2023-12-16
Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
Enlace a la fuente original: https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/folate-deficiency-in-rat-pups-during-weaning-causes-learning-and-memory-deficits/391AD532CCB76F5680C6C9C202F9795C#
URL Documento de licencia: http://repositori.urv.cat/ca/proteccio-de-dades/
Referencia al articulo segun fuente origial: British Journal Of Nutrition. 112 (8): 1323-1332
Referencia de l'ítem segons les normes APA: Berrocal-Zaragoza MI; Sequeira JM; Murphy MM; Fernandez-Ballart JD; Abdel Baki SG; Bergold PJ; Quadros EV (2014). Folate deficiency in rat pups during weaning causes learning and memory deficits. British Journal Of Nutrition, 112(8), 1323-1332. DOI: 10.1017/S0007114514002116
DOI del artículo: 10.1017/S0007114514002116
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2014
Tipo de publicación: Journal Publications
Repositori URV