Articles producció científica> Ciències Mèdiques Bàsiques

Effect of n-3 PUFA supplementation at different EPA:DHA ratios on the spontaneously hypertensive obese rat model of the metabolic syndrome

  • Dades identificatives

    Identificador: imarina:6388134
    Autors:
    Molinar-Toribio EPérez-Jiménez JRamos-Romero SRomeu MGiralt MTaltavull NMuñoz-Cortes MJáuregui OMéndez LMedina ITorres J
    Resum:
    Copyright © The Authors 2015. The increasing incidence of the metabolic syndrome (MetS), a combination of risk factors before the onset of CVD and type 2 diabetes, encourages studies on the role of functional food components such as long-chain n-3 PUFA as preventive agents. In the present study, we explore the effect of EPA and DHA supplementation in different proportions on spontaneously hypertensive obese (SHROB) rats, a model for the MetS in a prediabetic state with mild oxidative stress. SHROB rats were randomised into four groups (n 7), each supplemented with EPA/DHA at ratios of 1:1, 2:1 and 1:2, or soyabean oil as the control for 13 weeks. The results showed that in all the proportions tested, EPA/DHA supplementation significantly lowered total and LDL-cholesterol concentrations, compared with those of the control group. EPA/DHA supplementation at the ratios of 1:1 and 2:1 significantly decreased inflammation (C-reactive protein levels) and lowered oxidative stress (decreased excretion of urinary isoprostanes), mainly at the ratio of 1:2. The activity of antioxidant enzymes increased in erythrocytes, abdominal fat and kidneys, with magnitudes depending on the EPA:DHA ratio. PUFA mixtures from fish affected different MetS markers of CVD risk factors in SHROB rats, depending on the ratios of EPA/DHA supplementation. The activation of endogenous defence systems may be related to the reduction of inflammation and oxidative stress.
  • Altres:

    Autor segons l'article: Molinar-Toribio E; Pérez-Jiménez J; Ramos-Romero S; Romeu M; Giralt M; Taltavull N; Muñoz-Cortes M; Jáuregui O; Méndez L; Medina I; Torres J
    Departament: Ciències Mèdiques Bàsiques
    Autor/s de la URV: Giralt Batista, Montserrat / Muñoz Cortés, Mónica / Romeu Ferran, Marta / Taltavull Anglada, Núria
    Paraules clau: Spontaneously hypertensive rats Spontaneously hypertensive obese rats Omega-3 pufa N-3 pufa Metabolic syndrome Epa/dha Cardiovascular disease
    Resum: Copyright © The Authors 2015. The increasing incidence of the metabolic syndrome (MetS), a combination of risk factors before the onset of CVD and type 2 diabetes, encourages studies on the role of functional food components such as long-chain n-3 PUFA as preventive agents. In the present study, we explore the effect of EPA and DHA supplementation in different proportions on spontaneously hypertensive obese (SHROB) rats, a model for the MetS in a prediabetic state with mild oxidative stress. SHROB rats were randomised into four groups (n 7), each supplemented with EPA/DHA at ratios of 1:1, 2:1 and 1:2, or soyabean oil as the control for 13 weeks. The results showed that in all the proportions tested, EPA/DHA supplementation significantly lowered total and LDL-cholesterol concentrations, compared with those of the control group. EPA/DHA supplementation at the ratios of 1:1 and 2:1 significantly decreased inflammation (C-reactive protein levels) and lowered oxidative stress (decreased excretion of urinary isoprostanes), mainly at the ratio of 1:2. The activity of antioxidant enzymes increased in erythrocytes, abdominal fat and kidneys, with magnitudes depending on the EPA:DHA ratio. PUFA mixtures from fish affected different MetS markers of CVD risk factors in SHROB rats, depending on the ratios of EPA/DHA supplementation. The activation of endogenous defence systems may be related to the reduction of inflammation and oxidative stress.
    Àrees temàtiques: Zootecnia / recursos pesqueiros Saúde coletiva Química Odontología Nutrition and dietetics Nutrition & dietetics Nutrição Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Matemática / probabilidade e estatística Interdisciplinar General medicine Farmacia Engenharias iv Engenharias ii Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Biotecnología Biodiversidade Administração pública e de empresas, ciências contábeis e turismo
    Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 14752662
    Adreça de correu electrònic de l'autor: monica.munoz@urv.cat nuria.taltavull@urv.cat montse.giralt@urv.cat marta.romeu@urv.cat
    Identificador de l'autor: 0000-0002-3340-2650 0000-0002-7073-577X 0000-0002-2131-1858
    Data d'alta del registre: 2024-09-07
    Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
    Enllaç font original: https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/effect-of-n3-pufa-supplementation-at-different-epadha-ratios-on-the-spontaneously-hypertensive-obese-rat-model-of-the-metabolic-syndrome/D47DD8D947BBCC59C1310A797A2A14A7
    URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referència a l'article segons font original: British Journal Of Nutrition. 113 (6): 878-887
    Referència de l'ítem segons les normes APA: Molinar-Toribio E; Pérez-Jiménez J; Ramos-Romero S; Romeu M; Giralt M; Taltavull N; Muñoz-Cortes M; Jáuregui O; Méndez L; Medina I; Torres J (2015). Effect of n-3 PUFA supplementation at different EPA:DHA ratios on the spontaneously hypertensive obese rat model of the metabolic syndrome. British Journal Of Nutrition, 113(6), 878-887. DOI: 10.1017/S0007114514004437
    DOI de l'article: 10.1017/S0007114514004437
    Entitat: Universitat Rovira i Virgili
    Any de publicació de la revista: 2015
    Tipus de publicació: Journal Publications
  • Paraules clau:

    Medicine (Miscellaneous),Nutrition & Dietetics,Nutrition and Dietetics
    Spontaneously hypertensive rats
    Spontaneously hypertensive obese rats
    Omega-3 pufa
    N-3 pufa
    Metabolic syndrome
    Epa/dha
    Cardiovascular disease
    Zootecnia / recursos pesqueiros
    Saúde coletiva
    Química
    Odontología
    Nutrition and dietetics
    Nutrition & dietetics
    Nutrição
    Medicine (miscellaneous)
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Matemática / probabilidade e estatística
    Interdisciplinar
    General medicine
    Farmacia
    Engenharias iv
    Engenharias ii
    Educação física
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Ciências agrárias i
    Ciência de alimentos
    Biotecnología
    Biodiversidade
    Administração pública e de empresas, ciências contábeis e turismo
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