Autor segons l'article: Pons, Zara; Margalef, Maria; Bravo, Francisca I; Arola-Arnal, Anna; Muguerza, Begona
Departament: Bioquímica i Biotecnologia
Autor/s de la URV: Arola Arnal, Anna / Bravo Vázquez, Francisca Isabel / MARGALEF JORNET, MARIA / Muguerza Marquínez, Maria Begoña / PONS VILA, ZARA
Paraules clau: Wp waist perimeter Waist perimeter Waist circumference Time factors Tc total cholesterol Std standard Sbp systolic bp Risk factors Rich Rats, wistar Procyanidins Proanthocyanidins Polyphenols Phytotherapy Mets metabolic syndrome Metabolic syndrome Male Lm-gspe low-molecular-weight grape-seed polyphenol extract Lipids Lipid profile Leptin resistance Leptin Induced obesity Hypertension Htn hypertension Healthy Grape seed extract Flavanols Expression Diet Dbp diastolic bp Cocoa Cardiovascular diseases Cafeteria diet Caf200 caf diet-fed rats administered daily with 200 mg/kg of lm-gspe Caf cafeteria Bw body weight Bp blood pressure Body weight Blood-pressure Blood pressure Animals lipid profile flavanols cafeteria diet body weight wp waist perimeter tc total cholesterol std standard sbp systolic bp mets metabolic syndrome lm-gspe low-molecular-weight grape-seed polyphenol extract htn hypertension dbp diastolic bp caf200 caf diet-fed rats administered daily with 200 mg/kg of lm-gspe caf cafeteria bw body weight bp blood pressure
Resum: Copyright © The Authors 2017. The effects of grape-seed polyphenols against the development of hypertension and other cardiometabolic conditions associated with the metabolic syndrome (MetS) were studied in rats fed a high-fat, high-carbohydrate diet, known as the cafeteria (CAF) diet. Two groups of Wistar rats were fed standard (STD) or CAF diets for 12 weeks. The CAF diet-fed rats were administered different doses of a low-molecular-weight grape-seed polyphenol extract (LM-GSPE) (25, 100 and 200 mg/kg per d) or vehicle daily, and the STD diet-fed rats were administered LM-GSPE (100 mg/kg per d) or vehicle using ten animals per group. Body weight (BW), waist perimeter (WP) and systolic and diastolic blood pressures (BP) by the tail-cuff method were recorded weekly. The animals were housed in metabolic chambers every 2 weeks to estimate daily food and liquid intakes and to collect faeces and urine samples. The plasma lipid profile was analysed at time 0 and on the 4th, 7th, 10th and 12th weeks of the experiment. Moreover, plasma leptin was measured at the end of the experiment. Results demonstrated that LM-GSPE, when administered with the CAF diet, attenuated the increase in BP, BW, WP and improved lipid metabolism in these animals. However, although the 25- and 100-mg/kg per d doses were sufficient to produce beneficial effects on BP and lipid metabolism, a 200-mg/kg per d dose was necessary to have an effect on BW and WP. The present findings suggest that LM-GSPE is a good candidate for a BP-lowering agent that can also ameliorate other conditions associated with the MetS.
Àrees temàtiques: Zootecnia / recursos pesqueiros Saúde coletiva Química Odontología Nutrition and dietetics Nutrition & dietetics Nutrição Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Matemática / probabilidade e estatística Interdisciplinar General medicine Farmacia Engenharias iv Engenharias ii Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Biotecnología Biodiversidade Administração pública e de empresas, ciências contábeis e turismo
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 14752662
Adreça de correu electrònic de l'autor: franciscaisabel.bravo@urv.cat begona.muguerza@urv.cat anna.arola@urv.cat
Identificador de l'autor: 0000-0002-6468-3088 0000-0001-7384-8588 0000-0001-6529-1345
Data d'alta del registre: 2024-06-22
Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
Enllaç font original: https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/chronic-administration-of-grapeseed-polyphenols-attenuates-the-development-of-hypertension-and-improves-other-cardiometabolic-risk-factors-associated-with-the-metabolic-syndrome-in-cafeteria-dietfed-rats/E0D592D4BA008186CD6E31BF42A445D7
URL Document de llicència: http://repositori.urv.cat/ca/proteccio-de-dades/
Referència a l'article segons font original: British Journal Of Nutrition. 117 (2): 200-208
Referència de l'ítem segons les normes APA: Pons, Zara; Margalef, Maria; Bravo, Francisca I; Arola-Arnal, Anna; Muguerza, Begona (2017). Chronic administration of grape-seed polyphenols attenuates the development of hypertension and improves other cardiometabolic risk factors associated with the metabolic syndrome in cafeteria diet-fed rats. British Journal Of Nutrition, 117(2), 200-208. DOI: 10.1017/S0007114516004426
DOI de l'article: 10.1017/S0007114516004426
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2017
Tipus de publicació: Journal Publications
Repositori URV