Autor según el artículo: Pons Z; Margalef M; Bravo F; Arola-Arnal A; Muguerza B

Departamento: Bioquímica i Biotecnologia

Autor/es de la URV: Arola Arnal, Anna / Bravo Vázquez, Francisca Isabel / MARGALEF JORNET, MARIA / Muguerza Marquínez, Maria Begoña / PONS VILA, ZARA

Palabras clave: Waist perimeter Rich Procyanidins Proanthocyanidins Lipid profile Leptin resistance Induced obesity Healthy Flavanols Expression Cocoa Cafeteria diet Body weight Blood-pressure lipid profile flavanols cafeteria diet body weight wp waist perimeter tc total cholesterol std standard sbp systolic bp mets metabolic syndrome lm-gspe low-molecular-weight grape-seed polyphenol extract htn hypertension dbp diastolic bp caf200 caf diet-fed rats administered daily with 200 mg/kg of lm-gspe caf cafeteria bw body weight bp blood pressure

Resumen: Copyright © The Authors 2017. The effects of grape-seed polyphenols against the development of hypertension and other cardiometabolic conditions associated with the metabolic syndrome (MetS) were studied in rats fed a high-fat, high-carbohydrate diet, known as the cafeteria (CAF) diet. Two groups of Wistar rats were fed standard (STD) or CAF diets for 12 weeks. The CAF diet-fed rats were administered different doses of a low-molecular-weight grape-seed polyphenol extract (LM-GSPE) (25, 100 and 200 mg/kg per d) or vehicle daily, and the STD diet-fed rats were administered LM-GSPE (100 mg/kg per d) or vehicle using ten animals per group. Body weight (BW), waist perimeter (WP) and systolic and diastolic blood pressures (BP) by the tail-cuff method were recorded weekly. The animals were housed in metabolic chambers every 2 weeks to estimate daily food and liquid intakes and to collect faeces and urine samples. The plasma lipid profile was analysed at time 0 and on the 4th, 7th, 10th and 12th weeks of the experiment. Moreover, plasma leptin was measured at the end of the experiment. Results demonstrated that LM-GSPE, when administered with the CAF diet, attenuated the increase in BP, BW, WP and improved lipid metabolism in these animals. However, although the 25- and 100-mg/kg per d doses were sufficient to produce beneficial effects on BP and lipid metabolism, a 200-mg/kg per d dose was necessary to have an effect on BW and WP. The present findings suggest that LM-GSPE is a good candidate for a BP-lowering agent that can also ameliorate other conditions associated with the MetS.

Áreas temáticas: Zootecnia / recursos pesqueiros Saúde coletiva Química Odontología Nutrition and dietetics Nutrition & dietetics Nutrição Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Matemática / probabilidade e estatística Interdisciplinar General medicine Farmacia Engenharias iv Engenharias ii Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Biotecnología Biodiversidade Administração pública e de empresas, ciências contábeis e turismo

Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 14752662

Direcció de correo del autor: franciscaisabel.bravo@urv.cat begona.muguerza@urv.cat anna.arola@urv.cat

Identificador del autor: 0000-0002-6468-3088 0000-0001-7384-8588 0000-0001-6529-1345

Fecha de alta del registro: 2023-02-19

Versión del articulo depositado: info:eu-repo/semantics/publishedVersion

Enlace a la fuente original: https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/chronic-administration-of-grapeseed-polyphenols-attenuates-the-development-of-hypertension-and-improves-other-cardiometabolic-risk-factors-associated-with-the-metabolic-syndrome-in-cafeteria-dietfed-rats/E0D592D4BA008186CD6E31BF42A445D7

URL Documento de licencia: http://repositori.urv.cat/ca/proteccio-de-dades/

Referencia al articulo segun fuente origial: British Journal Of Nutrition. 117 (2): 200-208

Referencia de l'ítem segons les normes APA: Pons Z; Margalef M; Bravo F; Arola-Arnal A; Muguerza B (2017). Chronic administration of grape-seed polyphenols attenuates the development of hypertension and improves other cardiometabolic risk factors associated with the metabolic syndrome in cafeteria diet-fed rats. British Journal Of Nutrition, 117(2), 200-208. DOI: 10.1017/S0007114516004426

DOI del artículo: 10.1017/S0007114516004426

Entidad: Universitat Rovira i Virgili

Año de publicación de la revista: 2017

Tipo de publicación: Journal Publications