Articles producció científica> Química Física i Inorgànica

Copper-Catalyzed Borylative Ring Closing C-C Coupling toward Spiro- and Dispiroheterocycles

  • Dades identificatives

    Identificador: imarina:6389389
    Handle: https://hdl.handle.net/20.500.11797/imarina6389389
    Autors:
    Royes JNi SFarré ALa Cascia ECarbó JJCuenca ABMaseras FFernández E
    Resum:
    © 2018 American Chemical Society. The synthesis of spiroheterocyclic structures with a pendant methylene boronate substituent has been accomplished to promote further functionalization. A Cu-catalyzed borylative ring closing C-C coupling of an alkenyl halide is the key step toward the synthesis of [m.n]-spirocycles (m,n = 3-5). Computational studies on the mechanism reproduced all the experimental trends and explain the enhanced reactivity of systems leading to strained smaller rings. The optimized protocol also gives access to dispirocycle scaffolds, fully characterized by X-ray diffraction.

  • Altres:

    Autor segons l'article: Royes J; Ni S; Farré A; La Cascia E; Carbó JJ; Cuenca AB; Maseras F; Fernández E
    Departament: Química Física i Inorgànica
    Autor/s de la URV: Carbó Martin, Jorge Juan / Fernández Gutiérrez, Maria Elena / Fernández López, Elena / ROYES BUISAN, JORDI
    Paraules clau: Spiroheterocyclic structures Dft study Borylative cyclization
    Resum: © 2018 American Chemical Society. The synthesis of spiroheterocyclic structures with a pendant methylene boronate substituent has been accomplished to promote further functionalization. A Cu-catalyzed borylative ring closing C-C coupling of an alkenyl halide is the key step toward the synthesis of [m.n]-spirocycles (m,n = 3-5). Computational studies on the mechanism reproduced all the experimental trends and explain the enhanced reactivity of systems leading to strained smaller rings. The optimized protocol also gives access to dispirocycle scaffolds, fully characterized by X-ray diffraction.
    Àrees temàtiques: Química Materiais Interdisciplinar General chemistry Engenharias ii Ciências agrárias i Chemistry, physical Chemistry (miscellaneous) Chemistry (all) Catalysis Astronomia / física
    Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 21555435
    Adreça de correu electrònic de l'autor: j.carbo@urv.cat mariaelena.fernandez@urv.cat
    Identificador de l'autor: 0000-0002-3945-6721 0000-0001-9025-1791
    Data d'alta del registre: 2024-10-12
    Versió de l'article dipositat: info:eu-repo/semantics/acceptedVersion
    Enllaç font original: https://pubs.acs.org/doi/abs/10.1021/acscatal.8b00257
    URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referència a l'article segons font original: Acs Catalysis. 8 (4): 2833-2838
    Referència de l'ítem segons les normes APA: Royes J; Ni S; Farré A; La Cascia E; Carbó JJ; Cuenca AB; Maseras F; Fernández E (2018). Copper-Catalyzed Borylative Ring Closing C-C Coupling toward Spiro- and Dispiroheterocycles. Acs Catalysis, 8(4), 2833-2838. DOI: 10.1021/acscatal.8b00257
    DOI de l'article: 10.1021/acscatal.8b00257
    Entitat: Universitat Rovira i Virgili
    Any de publicació de la revista: 2018
    Tipus de publicació: Journal Publications

  • Paraules clau:

    Catalysis,Chemistry (Miscellaneous),Chemistry, Physical
    Spiroheterocyclic structures
    Dft study
    Borylative cyclization
    Química
    Materiais
    Interdisciplinar
    General chemistry
    Engenharias ii
    Ciências agrárias i
    Chemistry, physical
    Chemistry (miscellaneous)
    Chemistry (all)
    Catalysis
    Astronomia / física

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