Autor segons l'article: Husøy T; Martínez MA; Sharma RP; Kumar V; Andreassen M; Sakhi AK; Thomsen C; Dirven H
Departament: Enginyeria Química
Autor/s de la URV: Kumar, Vikas / Martínez Rodríguez, María Ángeles
Paraules clau: Young adult Serum Phthalates Performance liquid-chromatography Pbpk Parabens Norway Molecular structure Models, biological Middle aged Male Humans Human biomonitoring Foods Food contamination Female Exposure Esters Diethylhexyl phthalate Diet Dehp Cosmetics Children Catalonia Bisphenol-a Biological monitoring Aged Adult
Resum: © 2020 The Author(s) Phthalates are widely used as plasticisers in flexible plastics and containers for food and personal care products (PCPs) and contaminates foods and PCPs. A human biomonitoring (BM) study was performed to study exposure of chemicals from foods and PCPs. For two 24-h periods, adult volunteers (n = 144) in Norway kept diaries on food eaten and usage of PCPs, and collected 24-h urine. Aggregated exposure to di(2-ethylhexyl) phthalate (DEHP) from dietary and PCPs was estimated by Monte-Carlo simulation using Oracle Crystal Ball©. Simulated urinary concentrations using physiologically based pharmacokinetic (PBPK) models were compared with measured urinary metabolites of DEHP, mono-2-ethylhexyl phthalate (MEHP), mono-2-ethyl-5-hydroxyhexyl phthalate (MEHHP), mono-2-ethyl-5-oxohexyl phthalate (MEOHP) and mono-2-ethyl 5-carboxypentyl phthalate (MECCP). DEHP exposure from food are approximately 10 times higher than exposure than from PCPs. The main contributors to dietary exposure are dairy, grain, fruits and vegetables, meat and fish. Body lotion contribute most to the exposure of DEHP from PCPs. Forward-dosimetry gives good convergence with 24-h urinary concentrations of simulated and measured BM data. The measured concentration of the MECCP metabolite correlated well with simulated high exposure, while the measured concentrations of MEHP, MEHHP and MEOHP partly overlapped with both simulated low, medium and high metabolite exposure.
Àrees temàtiques: Toxicology Saúde coletiva Química Odontología Nutrição Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Food science & technology Food science Farmacia Ensino Engenharias iv Engenharias ii Enfermagem Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Biotecnología Biodiversidade Astronomia / física
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 0278-6915
Adreça de correu electrònic de l'autor: vikas.kumar@urv.cat mangeles.martinez@urv.cat
Identificador de l'autor: 0000-0002-9795-5967 0000-0001-8595-3772
Data d'alta del registre: 2024-06-28
Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
Referència a l'article segons font original: Food And Chemical Toxicology. 143 (111510): 111510-
Referència de l'ítem segons les normes APA: Husøy T; Martínez MA; Sharma RP; Kumar V; Andreassen M; Sakhi AK; Thomsen C; Dirven H (2020). Comparison of aggregated exposure to di(2-ethylhexyl) phthalate from diet and personal care products with urinary concentrations of metabolites using a PBPK model – Results from the Norwegian biomonitoring study in EuroMix. Food And Chemical Toxicology, 143(111510), 111510-. DOI: 10.1016/j.fct.2020.111510
URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2020
Tipus de publicació: Journal Publications
Repositori URV