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Comparison of aggregated exposure to di(2-ethylhexyl) phthalate from diet and personal care products with urinary concentrations of metabolites using a PBPK model – Results from the Norwegian biomonitoring study in EuroMix

  • Dades identificatives

    Identificador: imarina:6685100
    Autors:
    Husøy TMartínez MASharma RPKumar VAndreassen MSakhi AKThomsen CDirven H
    Resum:
    © 2020 The Author(s) Phthalates are widely used as plasticisers in flexible plastics and containers for food and personal care products (PCPs) and contaminates foods and PCPs. A human biomonitoring (BM) study was performed to study exposure of chemicals from foods and PCPs. For two 24-h periods, adult volunteers (n = 144) in Norway kept diaries on food eaten and usage of PCPs, and collected 24-h urine. Aggregated exposure to di(2-ethylhexyl) phthalate (DEHP) from dietary and PCPs was estimated by Monte-Carlo simulation using Oracle Crystal Ball©. Simulated urinary concentrations using physiologically based pharmacokinetic (PBPK) models were compared with measured urinary metabolites of DEHP, mono-2-ethylhexyl phthalate (MEHP), mono-2-ethyl-5-hydroxyhexyl phthalate (MEHHP), mono-2-ethyl-5-oxohexyl phthalate (MEOHP) and mono-2-ethyl 5-carboxypentyl phthalate (MECCP). DEHP exposure from food are approximately 10 times higher than exposure than from PCPs. The main contributors to dietary exposure are dairy, grain, fruits and vegetables, meat and fish. Body lotion contribute most to the exposure of DEHP from PCPs. Forward-dosimetry gives good convergence with 24-h urinary concentrations of simulated and measured BM data. The measured concentration of the MECCP metabolite correlated well with simulated high exposure, while the measured concentrations of MEHP, MEHHP and MEOHP partly overlapped with both simulated low, medium and high metabolite exposure.
  • Altres:

    Autor segons l'article: Husøy T; Martínez MA; Sharma RP; Kumar V; Andreassen M; Sakhi AK; Thomsen C; Dirven H
    Departament: Enginyeria Química
    Autor/s de la URV: Kumar, Vikas / Martínez Rodríguez, María Ángeles
    Paraules clau: Young adult Serum Phthalates Performance liquid-chromatography Pbpk Parabens Norway Molecular structure Models, biological Middle aged Male Humans Human biomonitoring Foods Food contamination Female Exposure Esters Diethylhexyl phthalate Diet Dehp Cosmetics Children Catalonia Bisphenol-a Biological monitoring Aged Adult
    Resum: © 2020 The Author(s) Phthalates are widely used as plasticisers in flexible plastics and containers for food and personal care products (PCPs) and contaminates foods and PCPs. A human biomonitoring (BM) study was performed to study exposure of chemicals from foods and PCPs. For two 24-h periods, adult volunteers (n = 144) in Norway kept diaries on food eaten and usage of PCPs, and collected 24-h urine. Aggregated exposure to di(2-ethylhexyl) phthalate (DEHP) from dietary and PCPs was estimated by Monte-Carlo simulation using Oracle Crystal Ball©. Simulated urinary concentrations using physiologically based pharmacokinetic (PBPK) models were compared with measured urinary metabolites of DEHP, mono-2-ethylhexyl phthalate (MEHP), mono-2-ethyl-5-hydroxyhexyl phthalate (MEHHP), mono-2-ethyl-5-oxohexyl phthalate (MEOHP) and mono-2-ethyl 5-carboxypentyl phthalate (MECCP). DEHP exposure from food are approximately 10 times higher than exposure than from PCPs. The main contributors to dietary exposure are dairy, grain, fruits and vegetables, meat and fish. Body lotion contribute most to the exposure of DEHP from PCPs. Forward-dosimetry gives good convergence with 24-h urinary concentrations of simulated and measured BM data. The measured concentration of the MECCP metabolite correlated well with simulated high exposure, while the measured concentrations of MEHP, MEHHP and MEOHP partly overlapped with both simulated low, medium and high metabolite exposure.
    Àrees temàtiques: Toxicology Saúde coletiva Química Odontología Nutrição Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Food science & technology Food science Farmacia Ensino Engenharias iv Engenharias ii Enfermagem Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Biotecnología Biodiversidade Astronomia / física
    Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 0278-6915
    Adreça de correu electrònic de l'autor: vikas.kumar@urv.cat mangeles.martinez@urv.cat
    Identificador de l'autor: 0000-0002-9795-5967 0000-0001-8595-3772
    Data d'alta del registre: 2024-06-28
    Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
    Enllaç font original: https://www.sciencedirect.com/science/article/pii/S0278691520304002
    Referència a l'article segons font original: Food And Chemical Toxicology. 143 (111510): 111510-
    Referència de l'ítem segons les normes APA: Husøy T; Martínez MA; Sharma RP; Kumar V; Andreassen M; Sakhi AK; Thomsen C; Dirven H (2020). Comparison of aggregated exposure to di(2-ethylhexyl) phthalate from diet and personal care products with urinary concentrations of metabolites using a PBPK model – Results from the Norwegian biomonitoring study in EuroMix. Food And Chemical Toxicology, 143(111510), 111510-. DOI: 10.1016/j.fct.2020.111510
    URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
    DOI de l'article: 10.1016/j.fct.2020.111510
    Entitat: Universitat Rovira i Virgili
    Any de publicació de la revista: 2020
    Tipus de publicació: Journal Publications
  • Paraules clau:

    Food Science,Food Science & Technology,Medicine (Miscellaneous),Toxicology
    Young adult
    Serum
    Phthalates
    Performance liquid-chromatography
    Pbpk
    Parabens
    Norway
    Molecular structure
    Models, biological
    Middle aged
    Male
    Humans
    Human biomonitoring
    Foods
    Food contamination
    Female
    Exposure
    Esters
    Diethylhexyl phthalate
    Diet
    Dehp
    Cosmetics
    Children
    Catalonia
    Bisphenol-a
    Biological monitoring
    Aged
    Adult
    Toxicology
    Saúde coletiva
    Química
    Odontología
    Nutrição
    Medicine (miscellaneous)
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Materiais
    Interdisciplinar
    Food science & technology
    Food science
    Farmacia
    Ensino
    Engenharias iv
    Engenharias ii
    Enfermagem
    Educação física
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Ciências agrárias i
    Ciência de alimentos
    Biotecnología
    Biodiversidade
    Astronomia / física
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