Autor segons l'article: Benítez-Páez A; Olivares M; Szajewska H; Pieścik-Lech M; Polanco I; Castillejo G; Nuñez M; Ribes-Koninckx C; Korponay-Szabó IR; Koletzko S; Meijer CR; Mearin ML; Sanz Y
Departament: Medicina i Cirurgia
Autor/s de la URV: Castillejo De Villasante, Gemma
Paraules clau: Risk Mothers Infants Human milk microbiota Hla genotype Contamination Children Celiac disease
Resum: © Copyright © 2020 Benítez-Páez, Olivares, Szajewska, Pieścik-Lech, Polanco, Castillejo, Nuñez, Ribes-Koninckx, Korponay-Szabó, Koletzko, Meijer, Mearin and Sanz. Celiac disease (CeD) is an immune-mediated disorder triggered by exposure to dietary gluten proteins in genetically predisposed individuals. In addition to the host genome, the microbiome has recently been linked to CeD risk and pathogenesis. To progress in our understanding of the role of breast milk microbiota profiles in CeD, we have analyzed samples from a sub-set of mothers (n = 49) included in the PreventCD project, whose children did or did not develop CeD. The results of the microbiota data analysis indicated that neither the BMI, HLA-DQ genotype, the CeD condition nor the gluten-free diet of the mothers could explain the human milk microbiota profiles. Nevertheless, we found that origin country, the offspring’s birth date and, consequently, the milk sampling date influenced the abundance and prevalence of microbes in human milk, undergoing a transition from an anaerobic to a more aerobic microbiota, including potential pathogenic species. Furthermore, certain microbial species were more abundant in milk samples from mothers whose children went on to develop CeD compared to those that remained healthy. These included increases in facultative methylotrophs such as Methylobacterium komagatae and Methylocapsa palsarum as well as in species such as Bacteroides vulgatus, that consumes fucosylated-oligosaccharides present in human milk, and other breast-abscess associated species. Theoretically, these microbiota components could be vertically transmitted from mothers-to-infants during breastfeeding, thereby influencing CeD risk.
Àrees temàtiques: Zootecnia / recursos pesqueiros Saúde coletiva Química Odontología Nutrição Microbiology (medical) Microbiology Medicina veterinaria Medicina ii Medicina i Materiais Matemática / probabilidade e estatística Interdisciplinar Geografía Geociências Farmacia Ensino Engenharias iii Engenharias ii Engenharias i Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Ciência da computação Biotecnología Biodiversidade Astronomia / física
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
Adreça de correu electrònic de l'autor: gemma.castillejo@urv.cat
Data d'alta del registre: 2023-02-23
Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
Enllaç font original: https://www.frontiersin.org/articles/10.3389/fmicb.2020.01335/full
Referència a l'article segons font original: Frontiers In Microbiology. 11 (1335):
Referència de l'ítem segons les normes APA: Benítez-Páez A; Olivares M; Szajewska H; Pieścik-Lech M; Polanco I; Castillejo G; Nuñez M; Ribes-Koninckx C; Korponay-Szabó IR; Koletzko S; Meijer CR; (2020). Breast-Milk Microbiota Linked to Celiac Disease Development in Children: A Pilot Study From the PreventCD Cohort. Frontiers In Microbiology, 11(1335), -. DOI: 10.3389/fmicb.2020.01335
URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
DOI de l'article: 10.3389/fmicb.2020.01335
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2020
Tipus de publicació: Journal Publications