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Consensus document of an expert group from the Spanish Society of Arteriosclerosis (SEA) on the clinical use of nuclear magnetic resonance to assess lipoprotein metabolism (Liposcale®)

  • Dades identificatives

    Identificador: imarina:7474170
    Autors:
    Pintó XMasana LCiveira FReal JIbarretxe DCandas BPuzo JDíaz JLAmigó NEsteban MValdivielso P
    Resum:
    © 2020 The Authors The assessment and prevention of cardiovascular risk (CVR) that persists in patients with dyslipidaemia despite treatment and achievement of goals specific to the plasma concentration of cholesterol linked to low density (c-LDL) is a clinical challenge today, and suggests that conventional lipid biomarkers are insufficient for an accurate assessment of CVR. Apart from their lipid content, there are other lipid particle characteristics. The results of this study show that there are a number of lipoprotein compounds that determine atherogenic potential and its influence on the CVR. However, such additional characteristics cannot be analysed by the techniques commonly used in clinical laboratories. Nuclear Magnetic Resonance (NMR) is a technique that allows a detailed analysis to be made of the amount, composition, and size of lipoproteins, as well as providing more information about the detailed status of lipid metabolism and CVR in dyslipidaemia patients. In this article a group of lipidologists from the Spanish Society of Arteriosclerosis review the existing evidence on the atherogenic mechanisms of particles and describe the technical basis and interpretation of the profiles lipoproteins obtained by MRI, with special reference to the test available in Spain (Liposcale®). Likewise, the main patient profiles are defined as such that an analysis would provide information of greater clinical interest. These include: a) Suspected mismatch between lipid concentrations and particles, a common situation in diabetes, obesity, metabolic syndrome; b) Early atherothrombotic cardiovascular disease (ECVA) or recurrent without CVR factors to justify it; c) Lipid disorders, rare or complex, such as extreme concentrations of c-HDL, and d) Clinical situations where cl
  • Altres:

    Autor segons l'article: Pintó X; Masana L; Civeira F; Real J; Ibarretxe D; Candas B; Puzo J; Díaz JL; Amigó N; Esteban M; Valdivielso P
    Departament: Medicina i Cirurgia
    Autor/s de la URV: Ibarretxe Gerediaga, Daiana / Masana Marín, Luis
    Paraules clau: Risk-factors Riesgo cardiovascular Remnant cholesterol Non-hdl cholesterol Low-density-lipoprotein Lipoproteins Lipoprotein particles Lipid-lowering therapy Ldl particle number Cardiovascular-disease Cardiovascular risk B-containing lipoproteins Apolipoprotein-b A-i resonancia magnética nuclear partículas lipoproteicas lipoproteins lipoproteínas lipoprotein particles cardiovascular risk
    Resum: © 2020 The Authors The assessment and prevention of cardiovascular risk (CVR) that persists in patients with dyslipidaemia despite treatment and achievement of goals specific to the plasma concentration of cholesterol linked to low density (c-LDL) is a clinical challenge today, and suggests that conventional lipid biomarkers are insufficient for an accurate assessment of CVR. Apart from their lipid content, there are other lipid particle characteristics. The results of this study show that there are a number of lipoprotein compounds that determine atherogenic potential and its influence on the CVR. However, such additional characteristics cannot be analysed by the techniques commonly used in clinical laboratories. Nuclear Magnetic Resonance (NMR) is a technique that allows a detailed analysis to be made of the amount, composition, and size of lipoproteins, as well as providing more information about the detailed status of lipid metabolism and CVR in dyslipidaemia patients. In this article a group of lipidologists from the Spanish Society of Arteriosclerosis review the existing evidence on the atherogenic mechanisms of particles and describe the technical basis and interpretation of the profiles lipoproteins obtained by MRI, with special reference to the test available in Spain (Liposcale®). Likewise, the main patient profiles are defined as such that an analysis would provide information of greater clinical interest. These include: a) Suspected mismatch between lipid concentrations and particles, a common situation in diabetes, obesity, metabolic syndrome; b) Early atherothrombotic cardiovascular disease (ECVA) or recurrent without CVR factors to justify it; c) Lipid disorders, rare or complex, such as extreme concentrations of c-HDL, and d) Clinical situations where classical analytical techniques cannot be applied, such as very low c-LDL values.
    Àrees temàtiques: Pharmacology (medical) Peripheral vascular disease Medicina iii Medicina i Cardiology and cardiovascular medicine
    Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 15781879
    Adreça de correu electrònic de l'autor: daiana.ibarretxe@urv.cat luis.masana@urv.cat
    Identificador de l'autor: 0000-0002-0789-4954
    Data d'alta del registre: 2024-08-24
    Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
    Enllaç font original: https://www.sciencedirect.com/science/article/pii/S0214916820300474
    URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referència a l'article segons font original: Clinica E Investigacion En Arteriosclerosis. 32 (5): 219-229
    Referència de l'ítem segons les normes APA: Pintó X; Masana L; Civeira F; Real J; Ibarretxe D; Candas B; Puzo J; Díaz JL; Amigó N; Esteban M; Valdivielso P (2020). Consensus document of an expert group from the Spanish Society of Arteriosclerosis (SEA) on the clinical use of nuclear magnetic resonance to assess lipoprotein metabolism (Liposcale®). Clinica E Investigacion En Arteriosclerosis, 32(5), 219-229. DOI: 10.1016/j.arteri.2020.04.004
    DOI de l'article: 10.1016/j.arteri.2020.04.004
    Entitat: Universitat Rovira i Virgili
    Any de publicació de la revista: 2020
    Tipus de publicació: Journal Publications
  • Paraules clau:

    Cardiology and Cardiovascular Medicine,Peripheral Vascular Disease,Pharmacology (Medical)
    Risk-factors
    Riesgo cardiovascular
    Remnant cholesterol
    Non-hdl cholesterol
    Low-density-lipoprotein
    Lipoproteins
    Lipoprotein particles
    Lipid-lowering therapy
    Ldl particle number
    Cardiovascular-disease
    Cardiovascular risk
    B-containing lipoproteins
    Apolipoprotein-b
    A-i
    resonancia magnética nuclear
    partículas lipoproteicas
    lipoproteins
    lipoproteínas
    lipoprotein particles
    cardiovascular risk
    Pharmacology (medical)
    Peripheral vascular disease
    Medicina iii
    Medicina i
    Cardiology and cardiovascular medicine
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